The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents

ÜNSAL, Erkan; ÇİFTÇİ, Furkan; ÇUBUK, Mehmet Özgür; FİLİK, armağan

The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents

Erkan ÜNSAL, (İstanbul Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İstanbul, Türkiye)

Mehmet Özgür ÇUBUK, (İstanbul Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İstanbul, Türkiye)

Armağan FİLİK, (İstanbul Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İstanbul, Türkiye)

Furkan ÇİFTÇİ (İstanbul Eğitim ve Araştırma Hastanesi, Göz Hastalıkları, İstanbul, Türkiye)

Retina-Vitreus

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Yıl: 2019 Cilt: 28 Sayı: 3 Sayfa Aralığı: 259 - 264 Metin Dili: İngilizce İndeks Tarihi: 06-10-2020

The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents

Öz:

Purpose: To analyze the effect of preoperative intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents on intraoperative and postoperative complications of pars plana vitrectomy (PPV) applying for diabetic vitreous hemorrhage treatment.Method: A retrospective study was designed to evaluate the effect of preoperative anti-VEGF agents. Patients treated with PPV for proliferative diabetic retinopathy related nonclearing vitreous hemorrhage were enrolled in this study. Patients received an intravitreal anti-VEGF injection (repackaged 1.25 mg/0.05 ml bevacizumab, 0.5 mg/0.05 mL ranibizumab, 2 mg/0.05 ml afl ibercept) before surgery (1 to 14 days before surgery) were included in group 1. Patients did not receive an anti-VEGF injection were included in group 2. Different groups were compared in terms of intraoperative and postoperative complications and duration of surgery.Results: Fifty-nine eyes of 59 patients have fulfi lled the inclusion criteria and were analyzed in this study. Thirty eyes of 30 patients were included in group 1, and 29 eyes of 29 patients were included in group 2. Final best-corrected visual acuity (BCVA) after surgery showed signifi cant improvement compared with baseline in 2 groups (p=0.001). Incidence of signifi cant intraoperative bleeding and the incidence of the iatrogenic retinal tear was higher in group 2 (p=0.045, p=0.049 respectively). Incidence of early and delayed recurrent vitreous hemorrhage (VH) did not differ signifi cantly between the 2 treatment groups (p=0.76, p=0.61 respectively). The duration of surgery in group 1 was signifi cantly shorter than group 2, (p=0.001).Conclusion: The preoperative anti-VEGF agents applying for diabetic VH facilitate a faster the surgery and achieve better operative results

Anahtar Kelime:

Preoperatif İntravitreal Anti-vasküler Endotelyal Büyüme Faktörünün Diabetik Vitreus Hemorajisi Tedavisinde Uygulanan Pars Plana Vitrektomi Üzerine Etkisi

Öz:

Amaç: Bu çalışmada preoperatif intravitreal anti-vasküler endotelyal büyüme faktörünün (anti-VEGF) diabetik (DM) vitreus hemorajisi (VH) tedavisinde uygulanan pars plana vitrektomi (PPV) cerrahisi üzerine etkilerinin değerlendirilmesi amaçlandı. Metod: Kliniğimizde 2014-2018 yılları arasında PPV cerrahisi ile tedavi edilen DM ilişkili vitreus hemorajisi olgularının dosyaları retrospektif şekilde tarandı. Cerrahi öncesi 1-14 gün arasında intravitreal anti-VEGF (1.25 mg/0.05 ml bevacizumab veya 0.5 mg/0.05 mL ranibizumab veya 2 mg/0.05 ml afl ibercept) uygulanan olgular grup 1, cerrahi öncesi anti-VEGF uygulanmayan olgular grup 2 olarak adlandırıldı ve çalışmaya dahil edildi. Farklı gruplar intraoperatif ve postoperatif komplikasyonlar açısından karşılaştırıldı. Preoperatif anti-VEGF tedavisinin cerrahi süresi üzerine etkisi araştırıldı Bulgular: Elli dokuz hastanın 59 gözü (30 göz grup 1, 29 göz grup 2) çalışmaya dahil edildi. Sonuç en iyi düzeltilmiş görme keskinliğinin (EİDGK) her iki grupta da anlamlışekilde artış gösterdiği saptandı, (p=0.001). İntraoperatif kanama ve intraoperatif iatrojenik yırtık insidansının grup 2’de anlamlı şekilde daha yüksek olduğu görüldü, (sırasıyla, p=0.045, p=0.049). Cerrahi süresinin grup 2 de anlamlı şekilde daha uzun olduğu görüldü, (p=0.001). Postoperatif erken ve geç tekrarlayan vitreus hemorajisi oranının iki grupta benzer olduğu belirlendi, (sırasıyla, p=0.76, p=0.61). Sonuç: Bu çalışmada preoperative anti-VEGF tedavisinin DM ilişkili VH tedavisinde cerrahi süreyi kısalttığı, intraoperatif komplikasyon oranını azalttığı ve cerrahi başarıyı olumlu yönde etkilediği saptanmıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	ÜNSAL E, ÇUBUK M, FİLİK a, ÇİFTÇİ F (2019). The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. , 259 - 264.
Chicago	ÜNSAL Erkan,ÇUBUK Mehmet Özgür,FİLİK armağan,ÇİFTÇİ Furkan The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. (2019): 259 - 264.
MLA	ÜNSAL Erkan,ÇUBUK Mehmet Özgür,FİLİK armağan,ÇİFTÇİ Furkan The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. , 2019, ss.259 - 264.
AMA	ÜNSAL E,ÇUBUK M,FİLİK a,ÇİFTÇİ F The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. . 2019; 259 - 264.
Vancouver	ÜNSAL E,ÇUBUK M,FİLİK a,ÇİFTÇİ F The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. . 2019; 259 - 264.
IEEE	ÜNSAL E,ÇUBUK M,FİLİK a,ÇİFTÇİ F "The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents." , ss.259 - 264, 2019.
ISNAD	ÜNSAL, Erkan vd. "The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents". (2019), 259-264.

APA	ÜNSAL E, ÇUBUK M, FİLİK a, ÇİFTÇİ F (2019). The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. Retina-Vitreus, 28(3), 259 - 264.
Chicago	ÜNSAL Erkan,ÇUBUK Mehmet Özgür,FİLİK armağan,ÇİFTÇİ Furkan The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. Retina-Vitreus 28, no.3 (2019): 259 - 264.
MLA	ÜNSAL Erkan,ÇUBUK Mehmet Özgür,FİLİK armağan,ÇİFTÇİ Furkan The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. Retina-Vitreus, vol.28, no.3, 2019, ss.259 - 264.
AMA	ÜNSAL E,ÇUBUK M,FİLİK a,ÇİFTÇİ F The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. Retina-Vitreus. 2019; 28(3): 259 - 264.
Vancouver	ÜNSAL E,ÇUBUK M,FİLİK a,ÇİFTÇİ F The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents. Retina-Vitreus. 2019; 28(3): 259 - 264.
IEEE	ÜNSAL E,ÇUBUK M,FİLİK a,ÇİFTÇİ F "The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents." Retina-Vitreus, 28, ss.259 - 264, 2019.
ISNAD	ÜNSAL, Erkan vd. "The Outcomes of Pars Plana Vitrectomy For Diabetic Vitreous Hemorrhage: The Effect of Preoperative Intravitreal Anti Vascular Endothelial Growth Factor Agents". Retina-Vitreus 28/3 (2019), 259-264.