Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer
Yıl: 2020 Cilt: 10 Sayı: 1 Sayfa Aralığı: 16 - 22 Metin Dili: İngilizce DOI: 10.4274/jarem.galenos.2018.2508 İndeks Tarihi: 07-10-2020
Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer
Öz: Objective: As early-stage larynx carcinoma is considered curable, we have investigated the possible differences among treatments with the contributionof advanced technology for maximum prevention of the development of secondary malignancies, and for the long-term quality of life. We comparedthe doses to the organs at risk, the conformity indexes (CI), and the total monitor units of patients with early-stage glottic laryngeal cancer with thepatients’ physical planning for 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and volumetric modulated arcradiotherapy (VMAT) using the Eclipse treatment planning system.Methods: Radiotherapy planning tomography sections of patients with early-stage (T1N0M0) glottic larynx cancer who underwent only radiotherapywere used. The sections were used for target volume and critical organ descriptions. Plans for 3DCRT, VMAT, 5-field IMRT, and 7-field IMRT were madeand were compared after the procedures. The patients did not receive elective nodal irradiation. A total of 63 Gy in 28 fractions was described for allpatients for the planning target volume (PTV).Results: There was no difference between the mean PTV dose for VMAT and 5-field and 7-field IMRT. VMAT had the best results for the heterogeneityindex and CI; 7-field IMRT had the best results for the mean dose and carotid artery volume receiving (V35 Gy) values. Although very low doses weredetected for the medulla spinalis for 3DCRT, the doses of the other three plans were acceptable.Conclusion: Due to the higher conformality and better protection of the critical organs, VMAT or IMRT is more appropriate rather than 3DCRT in RTtreatment of early-stage glottic larynx cancer. The use of 7-field IMRT yields positive results, particularly for the carotid arteries.
Anahtar Kelime: Erken Evre Glottik Larinks Kanserinde Farklı Radyoterapi Tekniklerinin Dozimetrik Karşılaştırılması
Öz: Amaç: Erken evre larinks karsinomu tedavi edilebilir kabul edildiğinden, uzun dönem hayat kalitesi sağlamak ve ikincil malignitelerin gelişimini azami önleyebilmek için kullanılan ileri teknoloji katkılı tedaviler arasında fark olup olmadığını inceledik. Erken evre glottik yerleşimli larinks kanserinde bilgisayar ortamında Eclipse planlama sistemi yardımıyla 3 boyutlu radyoterapi (3BKRT), yoğunluk ayarlı (IMRT) ve volümetrik ark (VMAT) radyoterapi tekniklerine uygun yapılacak olan fizik planlar ile risk altındaki organ dozları, konformite indeksleri (Kİ) ve hastanın toplam aldığı monitör ünitelerinin karşılaştırılması amaçlanmıştır.Yöntemler: Erken evre (T1N0M0) glottik larinks kanseri tanılı olup tedavisinde sadece radyoterapi uygulanmış olan hastaların, sistemde kayıtlı olan radyoterapi planlama tomografi kesitleri kullanıldı. Bu kesitler kullanılarak hedef volüm ve kritik organ tanımlamaları yapıldı. Bu işlemlerin ardından her hastaya 3BKRT, VMAT, IMRT 5 ve 7 alan tekniklerine uygun planlar yapılıp, bu planlar karşılaştırıldı. Hastalara elektif nodal ışınlama yapılmadı. Hastaların tamamı için PTV’ye 28 fraksiyonda toplam 63 Gy doz tanımlandı.Bulgular: PTV ortalama doz için VMAT ve IMRT (5 ve 7 alan) teknikleri arasında fark bulunmamıştır. Heterojenlik indeksi ve Kİ açısından VMAT, karotid arterlerin ortalama doz ve V35 değerleri için ise IMRT 7 alan teknikleriyle en iyi sonuçlar elde edildi. 3BKRT’de, medulla spinalis için çok düşük dozlar saptanmasına rağmen diğer üç plandan elde edilen doz miktarları da kabul edilebilir seviyededir. Sonuç: Erken evre glottik larinks kanserinin RT ile tedavisinde 3BKRT yerine yüksek konformalite ve kritik organları daha iyi koruma nedeniyle VMAT veya IMRT ile tedavi uygun bulunmuştur. IMRT tekniği olarak 7 alan seçilmesi, özellikle karotid arterler açısından olumlu olacaktır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | BERBER T, Demirhan B (2020). Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. , 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| Chicago | BERBER TANJU,Demirhan Birhan Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. (2020): 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| MLA | BERBER TANJU,Demirhan Birhan Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. , 2020, ss.16 - 22. 10.4274/jarem.galenos.2018.2508 |
| AMA | BERBER T,Demirhan B Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. . 2020; 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| Vancouver | BERBER T,Demirhan B Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. . 2020; 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| IEEE | BERBER T,Demirhan B "Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer." , ss.16 - 22, 2020. 10.4274/jarem.galenos.2018.2508 |
| ISNAD | BERBER, TANJU - Demirhan, Birhan. "Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer". (2020), 16-22. https://doi.org/10.4274/jarem.galenos.2018.2508 |
| APA | BERBER T, Demirhan B (2020). Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. JAREM, 10(1), 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| Chicago | BERBER TANJU,Demirhan Birhan Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. JAREM 10, no.1 (2020): 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| MLA | BERBER TANJU,Demirhan Birhan Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. JAREM, vol.10, no.1, 2020, ss.16 - 22. 10.4274/jarem.galenos.2018.2508 |
| AMA | BERBER T,Demirhan B Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. JAREM. 2020; 10(1): 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| Vancouver | BERBER T,Demirhan B Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer. JAREM. 2020; 10(1): 16 - 22. 10.4274/jarem.galenos.2018.2508 |
| IEEE | BERBER T,Demirhan B "Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer." JAREM, 10, ss.16 - 22, 2020. 10.4274/jarem.galenos.2018.2508 |
| ISNAD | BERBER, TANJU - Demirhan, Birhan. "Dosimetric Comparison of Radiotherapy Techniques for Treating Early-stage Glottic Larynx Cancer". JAREM 10/1 (2020), 16-22. https://doi.org/10.4274/jarem.galenos.2018.2508 |
