Biological Effects of Propolis on Cancer

Hamide DOĞAN, (Mersin University, Faculty of Arts and Sciences, Department of Biology, 33110 Mersin, Turkey)
Sibel SİLİCİ, (Erciyes University, Seyrani Faculty of Agriculture, Agricultural Biotechnology Department, 38030 Kayseri, Turkey)
Ahmet Ata ÖZÇİMEN (Mersin University, Faculty of Arts and Sciences, Department of Biology, 33110 Mersin, Turkey)
Türk Tarım - Gıda Bilim ve Teknoloji dergisi
31 5
Yıl: 2020 Cilt: 8 Sayı: 3 Sayfa Aralığı: 573 - 579 Metin Dili: İngilizce DOI: DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939 İndeks Tarihi: 07-10-2020

Biological Effects of Propolis on Cancer

Öz:
Propolis is a special resin and wax material collected from the leaves and shells of trees, buds andshoots of plants by honey bees (Apis mellifera L.). In recent years, many researchers have studiedthe chemical composition, biological activity and pharmacological properties of propolis. Thecolour, odour and pharmacological properties of the propolis composition also vary as thecomposition changes depending on the plant, region, season and bee colony. Flavonoids, aromaticacids, phenolic acids and esters are the main compounds responsible for the biological activity ofpropolis. A number of studies have been conducted on the use of propolis or its active ingredients inthe treatment of cancer. It has been observed that the use of propolis did not cause side effectsaccording to in-vitro and in-vivo studies. Propolis should be extracted with different compounds foruse in biological assays. The most commonly used compounds for extraction are ethanol, methanol,oil and water. A number of studies have been carried out showing the antitumor effect of propolisin cell culture and animal tests. The search for new drugs derived from natural products, which mayfunction as chemotherapeutic agents and have low side effects, has increased in recent years.Combination with antioxidant therapy may improve the side effects of chemotherapy on leukocytes,liver and kidney, thus increasing the effect of chemotherapy with dose increase.
Anahtar Kelime:

Kanserde Propolisin Biyolojik Etkileri

Öz:
Propolis, bal arıları (Apis mellifera L.) tarafından ağaçların yaprak ve kabuklarından, bitkilerin tomurcuk ve filizlerinden toplanan, özel reçine ve mumsu maddedir. Son yıllarda birçok araştırmacı propolisin kimyasal kompozisyonu, biyolojik aktivitesi ve farmakolojik özellikleri üzerine çalışmışlardır. Propolisin bileşimi bitkiye, bölgeye, mevsime ve arı kolonisine bağlı olarak değiştiğinden dolayı rengi, kokusu ve farmakolojik özellikleri de farklılık göstermektedir. Flavonoidler, aromatik asitler, fenolik asitler ve esterleri propolisin biyolojik aktivitelerinden sorumlu başlıca bileşiklerdir. Propolis veya aktif bileşenlerinin kanser tedavisinde kullanımıyla ilgili olarak çok sayıda çalışma yapılmıştır. In-vitro ve in-vivo yapılan çalışmalarda propolis kullanımının yan etkiye yol açmadığı gözlenmiştir. Biyolojik analizlerde kullanılmak üzere propolis farklı bileşikler ile ekstrakte edilmelidir. Ekstraksiyon işlemi için en çok kullanılan bileşikler ethanol, methanol, yağ ve sudur. Hücre kültür ve hayvan testlerinde propolisin antitumor etkisini gösteren çok sayıda çalışma yapılmıştır. Kemoterapötik ajanlar olarak işlev görebilecek ve yan etkileri düşük olan özellikle de doğal ürünlerden türetilmiş yeni ilaç arayışı son yıllarda artmıştır. Antioksidan terapiyle kombinasyon lökositlerin, karaciğer ve böbreğin üzerine kemoterapinin yan etkilerini iyileştirebilir ve böylelikle doz artırımı ile kemoterapinin etkisi arttırılabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Doğan H, Silici S, OZÇIMEN A (2020). Biological Effects of Propolis on Cancer. , 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
Chicago Doğan Hamide,Silici Sibel,OZÇIMEN AHMET ATA Biological Effects of Propolis on Cancer. (2020): 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
MLA Doğan Hamide,Silici Sibel,OZÇIMEN AHMET ATA Biological Effects of Propolis on Cancer. , 2020, ss.573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
AMA Doğan H,Silici S,OZÇIMEN A Biological Effects of Propolis on Cancer. . 2020; 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
Vancouver Doğan H,Silici S,OZÇIMEN A Biological Effects of Propolis on Cancer. . 2020; 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
IEEE Doğan H,Silici S,OZÇIMEN A "Biological Effects of Propolis on Cancer." , ss.573 - 579, 2020. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
ISNAD Doğan, Hamide vd. "Biological Effects of Propolis on Cancer". (2020), 573-579. https://doi.org/DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
APA Doğan H, Silici S, OZÇIMEN A (2020). Biological Effects of Propolis on Cancer. Türk Tarım - Gıda Bilim ve Teknoloji dergisi, 8(3), 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
Chicago Doğan Hamide,Silici Sibel,OZÇIMEN AHMET ATA Biological Effects of Propolis on Cancer. Türk Tarım - Gıda Bilim ve Teknoloji dergisi 8, no.3 (2020): 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
MLA Doğan Hamide,Silici Sibel,OZÇIMEN AHMET ATA Biological Effects of Propolis on Cancer. Türk Tarım - Gıda Bilim ve Teknoloji dergisi, vol.8, no.3, 2020, ss.573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
AMA Doğan H,Silici S,OZÇIMEN A Biological Effects of Propolis on Cancer. Türk Tarım - Gıda Bilim ve Teknoloji dergisi. 2020; 8(3): 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
Vancouver Doğan H,Silici S,OZÇIMEN A Biological Effects of Propolis on Cancer. Türk Tarım - Gıda Bilim ve Teknoloji dergisi. 2020; 8(3): 573 - 579. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
IEEE Doğan H,Silici S,OZÇIMEN A "Biological Effects of Propolis on Cancer." Türk Tarım - Gıda Bilim ve Teknoloji dergisi, 8, ss.573 - 579, 2020. DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
ISNAD Doğan, Hamide vd. "Biological Effects of Propolis on Cancer". Türk Tarım - Gıda Bilim ve Teknoloji dergisi 8/3 (2020), 573-579. https://doi.org/DOI: https://doi.org/10.24925/turjaf.v8i3.573-579.2939
Sayfa Oluşturulma Tarihi
17-04-2024 15:54

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