Aim: The aim of this study was to present a collaborative model between orthodontists and designers on how to use the design thinking method effectively in new product development processes. Materials and Method: In this study, two product development studies using design thinking model in the field of orthodontics were evaluated holistically by multi-case analysis method. The comparison of the evaluation results was interpreted with cross-case synthesis and a design model proposal for collaboration was formed. Results: Although both cases reflected designing products for orthodontics by using the design thinking method, different approaches were required because of the contextual differences. When the cases were evaluated with cross-case synthesis, 9 themes were constituted from their important similarities in terms of design collaboration. These themes had then been associated with the inspiration, ideation and implementation phases of the design thinking model, which enabled the identification of the “sense-making”, “embodying” and “verification” stages that will increase the collaboration efficiency of the specialists and designers in the design processes. In this direction, a design collaboration model suitable for orthodontics has been developed. Conclusion: The effect of the equipment used on both the patient and the specialists in the field of orthodontics and the linear relationship between the design processes and the professional practice of these equipments, make the cooperation between designers and specialists inevitable in product development process. In this direction, effective use of design thinking model will ensure that the new products to be designed will be patient-centered and effective.