The aim of this study was to investigate the effects of physiotherapy and rehabilitation in a male patient with a developed lymphedema due to Axillary Web Syndrome (AWS) and Herpes Zoster infection after breast cancer surgery. The circumferential measurement of the upper extremity of the 79-year-old patient was assessed with tape measure. The data obtained from this measurement converted to volumetric values using the FRUSTUM model. Local tissue water (LTW) ratio was measured with MoistureMeterD Compact (MMDc, Delfin Technologies, Kuopio, Finland). The perception of heaviness and tightness associated with lymphedema, shoulder functions, the shoulder range of movements, quality of life were evaluated by using Visual Analog Scale (VAS), universal goniometer, Quick Disabilities of the Arm, Shoulder and Hand (Quick-Dash) and Lymphedema Life Impact Scale (LLIS), respectively. The patient was administered complex decongestive therapy (CDT), kinesio taping, manual therapy, proprioceptive neuromuscular facilitation exercises and neuromuscular reeducation. The treatment phase was performed for 7 weeks, 3 days a week, a total of 21 sessions. After the treatment, the preventive phase of the CDT including self-drainage, compression garment, skin care and exercises was provided as a home program. According to the results, the volume difference between the affected and unaffected extremities decreased from 828.96 cm3 to 206.69 cm3. Local tissue water ratio in the affected extremity were decreased from 1.97 to 1.33 for the arm and 1.82 to 1.34 for the forearm. Additionally, upper limb function and quality of life were positively improved. This case report indicates that physiotherapy and rehabilitation in a male patient is an effective treatment for lymphedema related to herpes zoster infection after breast cancer surgery.