Yıl: 2020 Cilt: 27 Sayı: 4 Sayfa Aralığı: 1082 - 1087 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.11.780 İndeks Tarihi: 09-10-2020

Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures

Öz:
AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.
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APA KAYA Y, KARAARSLAN N, Yılmaz İ, SİRİN D, Yaman O, özbek h, ATEŞ Ö (2020). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. , 1082 - 1087. 10.5455/annalsmedres.2019.11.780
Chicago KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. (2020): 1082 - 1087. 10.5455/annalsmedres.2019.11.780
MLA KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. , 2020, ss.1082 - 1087. 10.5455/annalsmedres.2019.11.780
AMA KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. . 2020; 1082 - 1087. 10.5455/annalsmedres.2019.11.780
Vancouver KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. . 2020; 1082 - 1087. 10.5455/annalsmedres.2019.11.780
IEEE KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures." , ss.1082 - 1087, 2020. 10.5455/annalsmedres.2019.11.780
ISNAD KAYA, Yasin Emre vd. "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures". (2020), 1082-1087. https://doi.org/10.5455/annalsmedres.2019.11.780
APA KAYA Y, KARAARSLAN N, Yılmaz İ, SİRİN D, Yaman O, özbek h, ATEŞ Ö (2020). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, 27(4), 1082 - 1087. 10.5455/annalsmedres.2019.11.780
Chicago KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research 27, no.4 (2020): 1082 - 1087. 10.5455/annalsmedres.2019.11.780
MLA KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, vol.27, no.4, 2020, ss.1082 - 1087. 10.5455/annalsmedres.2019.11.780
AMA KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research. 2020; 27(4): 1082 - 1087. 10.5455/annalsmedres.2019.11.780
Vancouver KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research. 2020; 27(4): 1082 - 1087. 10.5455/annalsmedres.2019.11.780
IEEE KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures." Annals of Medical Research, 27, ss.1082 - 1087, 2020. 10.5455/annalsmedres.2019.11.780
ISNAD KAYA, Yasin Emre vd. "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures". Annals of Medical Research 27/4 (2020), 1082-1087. https://doi.org/10.5455/annalsmedres.2019.11.780