Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Yıl: 2020 Cilt: 27 Sayı: 4 Sayfa Aralığı: 1082 - 1087 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.11.780 İndeks Tarihi: 09-10-2020
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Öz: AbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | KAYA Y, KARAARSLAN N, Yılmaz İ, SİRİN D, Yaman O, özbek h, ATEŞ Ö (2020). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. , 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
Chicago | KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. (2020): 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
MLA | KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. , 2020, ss.1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
AMA | KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. . 2020; 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
Vancouver | KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. . 2020; 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
IEEE | KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures." , ss.1082 - 1087, 2020. 10.5455/annalsmedres.2019.11.780 |
ISNAD | KAYA, Yasin Emre vd. "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures". (2020), 1082-1087. https://doi.org/10.5455/annalsmedres.2019.11.780 |
APA | KAYA Y, KARAARSLAN N, Yılmaz İ, SİRİN D, Yaman O, özbek h, ATEŞ Ö (2020). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, 27(4), 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
Chicago | KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research 27, no.4 (2020): 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
MLA | KAYA Yasin Emre,KARAARSLAN Numan,Yılmaz İbrahim,SİRİN Duygu YAŞAR,Yaman Onur,özbek hanefi,ATEŞ Özkan Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, vol.27, no.4, 2020, ss.1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
AMA | KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research. 2020; 27(4): 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
Vancouver | KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research. 2020; 27(4): 1082 - 1087. 10.5455/annalsmedres.2019.11.780 |
IEEE | KAYA Y,KARAARSLAN N,Yılmaz İ,SİRİN D,Yaman O,özbek h,ATEŞ Ö "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures." Annals of Medical Research, 27, ss.1082 - 1087, 2020. 10.5455/annalsmedres.2019.11.780 |
ISNAD | KAYA, Yasin Emre vd. "Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures". Annals of Medical Research 27/4 (2020), 1082-1087. https://doi.org/10.5455/annalsmedres.2019.11.780 |