Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever

CEBI, ALPER HAN; KALYONCU, MUKADDES; demir, ferhat

doi:10.5606/ArchRheumatol.2020.7414

Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever

Ferhat DEMİR, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Çocuk Romatoloji Anabilim Dalı, Trabzon, Türkiye)

Alper Han ÇEBİ, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Trabzon, Türkiye)

Mukaddes KALYONCU (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Çocuk Romatoloji Anabilim Dalı, Trabzon, Türkiye)

Archives of Rheumatology

1 0

Yıl: 2020 Cilt: 35 Sayı: 1 Sayfa Aralığı: 52 - 59 Metin Dili: İngilizce DOI: 10.5606/ArchRheumatol.2020.7414 İndeks Tarihi: 10-10-2020

Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever

Öz:

Objectives: This study aims to evaluate the plasma expression of microribonucleic acids (miRNAs) that may be associated with the pathogenesis offamilial Mediterranean fever (FMF).Patients and methods: Thirty patients with FMF (18 males, 12 females; mean age 9.1±4.7 years; range, 3 to 15.5 years) and 30 age- and sex-matchedhealthy children (18 males, 12 females; mean age 9.5±4.6 years; range, 4 to 16.5 years) were included in this study. The plasma levels of four candidatemiRNAs (miRNA-16, miRNA-155, miRNA-204 and miRNA-451) were measured in all subjects. The plasma levels of miRNAs were analyzed withreal-time polymerase chain reaction in attack and remission periods of patients and healthy controls (HCs).Results: Plasma miRNA-204 levels of FMF patients were decreased 6.5 fold in remission period compared to HCs (p<0.001). This decrease was moreprominent in M694V mutation carriers. Plasma miRNA-155 levels of FMF patients were lower in remission period (p=0.03).Conclusion: Our findings showed significant alterations in the plasma expression of miRNA-155 and miRNA-204 in FMF patients compared to HCs.Our data suggest that miRNA-155 and miRNA-204 may be related to the pathogenesis of FMF. Further comprehensive and functional researches mayhelp to clarify the role of miRNAs in FMF and elucidate the pathogenesis of the disease.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	demir f, CEBI A, KALYONCU M (2020). Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. , 52 - 59. 10.5606/ArchRheumatol.2020.7414
Chicago	demir ferhat,CEBI ALPER HAN,KALYONCU MUKADDES Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. (2020): 52 - 59. 10.5606/ArchRheumatol.2020.7414
MLA	demir ferhat,CEBI ALPER HAN,KALYONCU MUKADDES Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. , 2020, ss.52 - 59. 10.5606/ArchRheumatol.2020.7414
AMA	demir f,CEBI A,KALYONCU M Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. . 2020; 52 - 59. 10.5606/ArchRheumatol.2020.7414
Vancouver	demir f,CEBI A,KALYONCU M Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. . 2020; 52 - 59. 10.5606/ArchRheumatol.2020.7414
IEEE	demir f,CEBI A,KALYONCU M "Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever." , ss.52 - 59, 2020. 10.5606/ArchRheumatol.2020.7414
ISNAD	demir, ferhat vd. "Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever". (2020), 52-59. https://doi.org/10.5606/ArchRheumatol.2020.7414

APA	demir f, CEBI A, KALYONCU M (2020). Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology, 35(1), 52 - 59. 10.5606/ArchRheumatol.2020.7414
Chicago	demir ferhat,CEBI ALPER HAN,KALYONCU MUKADDES Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology 35, no.1 (2020): 52 - 59. 10.5606/ArchRheumatol.2020.7414
MLA	demir ferhat,CEBI ALPER HAN,KALYONCU MUKADDES Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology, vol.35, no.1, 2020, ss.52 - 59. 10.5606/ArchRheumatol.2020.7414
AMA	demir f,CEBI A,KALYONCU M Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology. 2020; 35(1): 52 - 59. 10.5606/ArchRheumatol.2020.7414
Vancouver	demir f,CEBI A,KALYONCU M Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever. Archives of Rheumatology. 2020; 35(1): 52 - 59. 10.5606/ArchRheumatol.2020.7414
IEEE	demir f,CEBI A,KALYONCU M "Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever." Archives of Rheumatology, 35, ss.52 - 59, 2020. 10.5606/ArchRheumatol.2020.7414
ISNAD	demir, ferhat vd. "Assessment of Circulating Microribonucleic Acids in Patients With Familial Mediterranean Fever". Archives of Rheumatology 35/1 (2020), 52-59. https://doi.org/10.5606/ArchRheumatol.2020.7414