Yıl: 2020 Cilt: 35 Sayı: 2 Sayfa Aralığı: 247 - 253 Metin Dili: İngilizce DOI: 10.46497/ArchRheumatol.2020.7456 İndeks Tarihi: 13-10-2020

Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life

Öz:
Objectives: This study aims to evaluate the relationship between C-reactive protein (CRP)/albumin ratio (CAR) and disease activity, quality of life(QoL), and physical function in rheumatoid arthritis (RA).Patients and methods: A total of 121 RA patients (22 males, 99 females; mean age 57.6±11.2 years; range, 32 to 85 years) applying to AnkaraUniversity School of Medicine Rheumatology Outpatient Clinic between January 2019 and February 2019 were included in this cross-sectional study.The inclusion criteria were fulfilling the American College of Rheumatology/European League Against Rheumatism 2010 RA classification criteria,being over 18 years and accepting to participate in the study. Demographic and clinical parameters including serum erythrocyte sedimentation rate(ESR), CRP and albumin levels were recorded. Disease activity was measured using Disease Activity Score 28 (DAS28)-ESR. General health, fatigue, andpain were questioned by means of a 100 mm visual analog scale (VAS). The QoL was assessed with the Rheumatoid Arthritis Quality of Life (RAQoL)Questionnaire. The functional status was determined using the Health Assessment Questionnaire (HAQ).Results: Rheumatoid factor (RF) was positive in 56.2% of the patients. The median ESR was 19.0 mm/hour (interquartile range [IQR]: 19.5) and medianCRP was 5.6 (IQR: 9) mg/L. The median CAR was 1.3 (IQR: 2.1) and median DAS 28-ESR was 3.6 (IQR: 1.5). There was a significant but weak correlationbetween CAR and DAS28-ESR (p<0.001, Spearman’s correlation coefficient [rs]=0.327). Moreover, CAR was positively correlated with ESR, CRP, andVAS physician’s global assessment (p<0.001, rs=0.497; p<0.001, rs=0.987, p<0.001, rs=0.401, respectively). However, no correlation was observedbetween CAR, HAQ, and RAQoL. In the RF positive group, there was a significant but weak correlation between CAR and RF titers (p=0.016, rs=0.292).Conclusion: We observed a positive but weak correlation between CAR and DAS28-ESR, ESR, and the RF titer. Further studies are warranted toinvestigate the role of CAR in RA.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Sunar İ, ataman s (2020). Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. , 247 - 253. 10.46497/ArchRheumatol.2020.7456
Chicago Sunar İsmihan,ataman sebnem Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. (2020): 247 - 253. 10.46497/ArchRheumatol.2020.7456
MLA Sunar İsmihan,ataman sebnem Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. , 2020, ss.247 - 253. 10.46497/ArchRheumatol.2020.7456
AMA Sunar İ,ataman s Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. . 2020; 247 - 253. 10.46497/ArchRheumatol.2020.7456
Vancouver Sunar İ,ataman s Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. . 2020; 247 - 253. 10.46497/ArchRheumatol.2020.7456
IEEE Sunar İ,ataman s "Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life." , ss.247 - 253, 2020. 10.46497/ArchRheumatol.2020.7456
ISNAD Sunar, İsmihan - ataman, sebnem. "Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life". (2020), 247-253. https://doi.org/10.46497/ArchRheumatol.2020.7456
APA Sunar İ, ataman s (2020). Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. Archives of Rheumatology, 35(2), 247 - 253. 10.46497/ArchRheumatol.2020.7456
Chicago Sunar İsmihan,ataman sebnem Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. Archives of Rheumatology 35, no.2 (2020): 247 - 253. 10.46497/ArchRheumatol.2020.7456
MLA Sunar İsmihan,ataman sebnem Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. Archives of Rheumatology, vol.35, no.2, 2020, ss.247 - 253. 10.46497/ArchRheumatol.2020.7456
AMA Sunar İ,ataman s Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. Archives of Rheumatology. 2020; 35(2): 247 - 253. 10.46497/ArchRheumatol.2020.7456
Vancouver Sunar İ,ataman s Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life. Archives of Rheumatology. 2020; 35(2): 247 - 253. 10.46497/ArchRheumatol.2020.7456
IEEE Sunar İ,ataman s "Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life." Archives of Rheumatology, 35, ss.247 - 253, 2020. 10.46497/ArchRheumatol.2020.7456
ISNAD Sunar, İsmihan - ataman, sebnem. "Serum C-Reactive Protein/Albumin Ratio in Rheumatoid Arthritis and its Relationship With Disease Activity, Physical Function, and Quality of Life". Archives of Rheumatology 35/2 (2020), 247-253. https://doi.org/10.46497/ArchRheumatol.2020.7456