Yıl: 2020 Cilt: 12 Sayı: 1 Sayfa Aralığı: 63 - 70 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2019.2019.0082 İndeks Tarihi: 13-10-2020

Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers

Öz:
Objective: Macular damage may be observed in obesity and metabolic syndrome (MetS), a condition which leads to chronic subclinical inflammation and affects most organ systems. To investigate the association between macular variability and anthropometric measurements, metabolic parameters, and inflammatory markers in children and adolescents with MetS.Methods: Two hundred and twenty eyes of 62 obese and 48 healthy children and adolescents were examined. Bilateral macular retinal thickness (MRT) and macular retinal volume (MRV) were measured in all subjects using optical coherence tomography. Associations between mean MRT and mean MRV and age, auxological measurements including body mass index standard deviation scores (BMI-SDS)and waist circumference-SDS (WC-SDS), metabolic parameters and inflammatory parameters including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio and systemic immune-inflammatory index (SIII) were investigated.Results: No statistically significant difference was observed between the groups in terms of age or sex distribution (p>0.05). Mean MRT (r=-0.326, p=0.007) and MRV (r=-0.303, p=0.007) values in the obese group with MetS decreased as homeostasis model assessmentinsulin resistance (HOMA-IR) values increased. SIII values were higher in obese groups, but particularly in obese subject with MetS, compared to the control group (p=0.021). The decrease in mean MRT (r=-0.544, p=0.046) and MRV (r=-0.651, p=0.031) in the obese subjects with MetS was negatively correlated with NLR. Mean MRT and MRV decreased in all obese subjects as SIII increased (p<0.05).Conclusion: This is the first study to show that mean MRT and MRV values decrease as BMI-SDS, WC-SDS and HOMA-IR increase in obese children and adolescents with MetS. NLR and SIII may serve as markers of chronic inflammation in obese children with MetS associated with macular damage.
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APA ÖZTÜRK A, Özen B, ÇATLI G, Dundar B (2020). Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. , 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
Chicago ÖZTÜRK A. Hakan,Özen Bediz,ÇATLI Gönül,Dundar Bumin N Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. (2020): 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
MLA ÖZTÜRK A. Hakan,Özen Bediz,ÇATLI Gönül,Dundar Bumin N Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. , 2020, ss.63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
AMA ÖZTÜRK A,Özen B,ÇATLI G,Dundar B Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. . 2020; 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
Vancouver ÖZTÜRK A,Özen B,ÇATLI G,Dundar B Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. . 2020; 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
IEEE ÖZTÜRK A,Özen B,ÇATLI G,Dundar B "Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers." , ss.63 - 70, 2020. 10.4274/jcrpe.galenos.2019.2019.0082
ISNAD ÖZTÜRK, A. Hakan vd. "Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers". (2020), 63-70. https://doi.org/10.4274/jcrpe.galenos.2019.2019.0082
APA ÖZTÜRK A, Özen B, ÇATLI G, Dundar B (2020). Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. Journal of Clinical Research in Pediatric Endocrinology, 12(1), 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
Chicago ÖZTÜRK A. Hakan,Özen Bediz,ÇATLI Gönül,Dundar Bumin N Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. Journal of Clinical Research in Pediatric Endocrinology 12, no.1 (2020): 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
MLA ÖZTÜRK A. Hakan,Özen Bediz,ÇATLI Gönül,Dundar Bumin N Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. Journal of Clinical Research in Pediatric Endocrinology, vol.12, no.1, 2020, ss.63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
AMA ÖZTÜRK A,Özen B,ÇATLI G,Dundar B Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. Journal of Clinical Research in Pediatric Endocrinology. 2020; 12(1): 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
Vancouver ÖZTÜRK A,Özen B,ÇATLI G,Dundar B Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers. Journal of Clinical Research in Pediatric Endocrinology. 2020; 12(1): 63 - 70. 10.4274/jcrpe.galenos.2019.2019.0082
IEEE ÖZTÜRK A,Özen B,ÇATLI G,Dundar B "Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers." Journal of Clinical Research in Pediatric Endocrinology, 12, ss.63 - 70, 2020. 10.4274/jcrpe.galenos.2019.2019.0082
ISNAD ÖZTÜRK, A. Hakan vd. "Macular Variability in Children and Adolescents with Metabolic Syndrome: A Cross-sectional Study Examining the Associations with Anthropometric Measurements, Metabolic Parameters and Inflammatory Markers". Journal of Clinical Research in Pediatric Endocrinology 12/1 (2020), 63-70. https://doi.org/10.4274/jcrpe.galenos.2019.2019.0082