Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study

HAN, Jinyan; Li, Guimei; SHANG, Xiaohong; WANG, Fengxue; WANG, Zengmin

doi:10.4274/jcrpe.galenos.2019.2019.0086

Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study

Fengxue WANG, (Girilmemişş)

Jinyan HAN, (Girilmemişş)

Zengmin WANG, (Girilmemişş)

Xiaohong SHANG, (Girilmemişş)

Guimei LI (Girilmemişş)

Journal of Clinical Research in Pediatric Endocrinology

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Yıl: 2020 Cilt: 12 Sayı: 1 Sayfa Aralığı: 71 - 78 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2019.2019.0086 İndeks Tarihi: 13-10-2020

Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study

Öz:

Objective: The aim was to assess growth velocity (GV) during human recombinant growth hormone (hGH) treatment of children with multiple pituitary hormone deficiency (MPHD) caused by pituitary stalk interruption syndrome (PSIS) and to analyze the characteristics of patients that attained normal adult heights.Methods: Data from 74 (16 female) children with MPHD caused by PSIS with GH, thyroid stimulating hormone, gonadotropin and adrenocorticotropic hormone deficiencies were collected. Subjects were divided into groups: 12 pre-pubescent females (Female-Group) and 36 pre-pubescent males (Male-Group 1). The remaining 22 males were further sub-divided into two groups (Male-Group 2 and MaleGroup 3) according to the initiation of gonadotropin replacement treatment, based on bone age and height.Results: No differences in change in height standard deviation score (△HtSDS) and GV were observed at different time points of hGH treatment between the Female-Group and Male-Group 1 (p>0.05). GV was significantly greater in the first year of hGH therapy than in subsequent years: Female-Group p=0.011; Male-Group 1 p<0.001; Male-Group 2 p=0.005; and Male-Group 3 p=0.046. Adult heightwas achieved by 23 (19 males and 4 females) patients. The total gain in height positively correlated with the GV during the first year (r=0.626, p<0.001).Conclusion: GV during hGH treatment were similar amongst pre-pubescent males and females with MPHD caused by PSIS. GV during the first year of hGH treatment appears to be an effective predictor of final height in patients with MPHD caused by PSIS.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	WANG F, HAN J, WANG Z, SHANG X, Li G (2020). Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. , 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
Chicago	WANG Fengxue,HAN Jinyan,WANG Zengmin,SHANG Xiaohong,Li Guimei Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. (2020): 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
MLA	WANG Fengxue,HAN Jinyan,WANG Zengmin,SHANG Xiaohong,Li Guimei Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. , 2020, ss.71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
AMA	WANG F,HAN J,WANG Z,SHANG X,Li G Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. . 2020; 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
Vancouver	WANG F,HAN J,WANG Z,SHANG X,Li G Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. . 2020; 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
IEEE	WANG F,HAN J,WANG Z,SHANG X,Li G "Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study." , ss.71 - 78, 2020. 10.4274/jcrpe.galenos.2019.2019.0086
ISNAD	WANG, Fengxue vd. "Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study". (2020), 71-78. https://doi.org/10.4274/jcrpe.galenos.2019.2019.0086

APA	WANG F, HAN J, WANG Z, SHANG X, Li G (2020). Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. Journal of Clinical Research in Pediatric Endocrinology, 12(1), 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
Chicago	WANG Fengxue,HAN Jinyan,WANG Zengmin,SHANG Xiaohong,Li Guimei Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. Journal of Clinical Research in Pediatric Endocrinology 12, no.1 (2020): 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
MLA	WANG Fengxue,HAN Jinyan,WANG Zengmin,SHANG Xiaohong,Li Guimei Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. Journal of Clinical Research in Pediatric Endocrinology, vol.12, no.1, 2020, ss.71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
AMA	WANG F,HAN J,WANG Z,SHANG X,Li G Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. Journal of Clinical Research in Pediatric Endocrinology. 2020; 12(1): 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
Vancouver	WANG F,HAN J,WANG Z,SHANG X,Li G Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study. Journal of Clinical Research in Pediatric Endocrinology. 2020; 12(1): 71 - 78. 10.4274/jcrpe.galenos.2019.2019.0086
IEEE	WANG F,HAN J,WANG Z,SHANG X,Li G "Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study." Journal of Clinical Research in Pediatric Endocrinology, 12, ss.71 - 78, 2020. 10.4274/jcrpe.galenos.2019.2019.0086
ISNAD	WANG, Fengxue vd. "Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre Study". Journal of Clinical Research in Pediatric Endocrinology 12/1 (2020), 71-78. https://doi.org/10.4274/jcrpe.galenos.2019.2019.0086