Yıl: 2020 Cilt: 58 Sayı: 1 Sayfa Aralığı: 65 - 71 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2019.5584 İndeks Tarihi: 29-07-2022

Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women

Öz:
Aim: To assess the risk factors associated with high rate of insufficient endometrial sampling on endometrial biopsy in postmenopausal women.Methods: Data were retrieved from the records of 522 consecutive patients who underwent endometrial sampling. Logistic regression analyses were performed to determine various factors associated with scanty endometrial biopsy. The exclusion criteria included patient refusal, uncertain menopausal status, cervical carcinoma detected after sampling and unavailable records.Results: The sample was insufficient for a definitive diagnosis in 143 (25.9%) patients. Out of these, 53 cases were investigated with invasive procedures. Further histopathological examination revealed that five (9.4%) patients had uterine malignancy. Based on the multivariate analysis, time since the onset of menopause [Odds ratio (OR)=1.044, 95% confidence interval (CI)=1.000-1.090, p=0.049] was significantly associated with insufficient endometrial biopsy in cases with a endometrial thickness of >12 mm on ultrasonography (OR=0.624, 95% CI=0.472-0.824, p=0.001). The use of dilation and curettage technique (OR=0.662, 95% CI=0.522-0.841, p=0.001) decreased the risk of insufficient sampling on endometrial biopsy.Conclusion: Time since the onset of menopause and the thickness of endometrium were significant independent factors associated with insufficient sample. Using Karman cannula for endometrial aspiration may not be a reliable method in the evaluation of postmenopausal women. An insufficient endometrial sample does not rule out endometrial carcinoma, therefore, a further histopathological examination is recommended.
Anahtar Kelime:

Postmenopozal Kadınlarda Yetersiz Endometrial Biyopsi Sonucu ile İlişkili Faktörler

Öz:
Amaç: Postmenopozal kadınlarda endometrial biyopsi patoloji sonucunun yetersiz doku olarak saptanması ile ilişkili risk faktörlerini değerlendirmektir. Yöntemler: Endometrial örnekleme yapılan ardışık 552 hastanın kayıtları incelenerek veriler toplandı. Endometrial örneklemenin yetersizliğine ilişkin faktörleri belirlemek için lojistik regresyon analizleri yapıldı. Hastanın onayının olmaması, belirsiz menapozal durum, örnekleme sonrası serviks kanseri saptanması ve hastanın kayıtlarına ulaşamama dışlanma kriterleri olarak kabul edildi. Bulgular: Endometrial örneklem 143 (%25,9) hastada kesin tanı için yeterli değildi. Bu vakaların 53’üne invaziv işlem uygulandı. Ek histopatolojik inceleme sonucunda beş (%9,4) hastada uterus malignitesi saptandı. Multivariate analiz sonucunda, yetersiz endometrial biyopsi sonuçları ile menopoz başlangıcından itibaren geçen süre (OR=1,044, % 95 CI=1,000-1,090, p=0,049) arasında anlamlı ilişki saptandı. Ultrasonografide endometrial kalınlığın >12 mm olması (OR=0,624, %95 CI=0,472-0,824, p=0,001), dilatasyon ve kürtaj tekniğinin uygulanması (OR=0,662, %95 CI=0,522-0.841, p=0,001) endometrial biyopside yetersiz örnek saptanma riskini azalttığı gösterildi. Sonuç: Menopoz başlangıcından bu yana geçen süre ve endometrium kalınlığı, yetersiz örneklem ile ilişkili önemli bağımsız faktörlerdir. Endometrial aspirasyon için Karman kanülünün kullanımı, postmenapozal kadınların değerlendirilmesinde güvenilir bir teknik olmayabilir. Yetersiz endometrial örnek endometrial karsinomu ekarte ettirmez, bu nedenle ek bir histopatolojik inceleme önerilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Ates S, Gokmen Karasu A, cali ozturk h, SOYMAN Z, uysal ö (2020). Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. , 65 - 71. 10.4274/haseki.galenos.2019.5584
Chicago Ates Seda,Gokmen Karasu Ayse Filiz,cali ozturk halime,SOYMAN ZEYNEP,uysal ömer Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. (2020): 65 - 71. 10.4274/haseki.galenos.2019.5584
MLA Ates Seda,Gokmen Karasu Ayse Filiz,cali ozturk halime,SOYMAN ZEYNEP,uysal ömer Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. , 2020, ss.65 - 71. 10.4274/haseki.galenos.2019.5584
AMA Ates S,Gokmen Karasu A,cali ozturk h,SOYMAN Z,uysal ö Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. . 2020; 65 - 71. 10.4274/haseki.galenos.2019.5584
Vancouver Ates S,Gokmen Karasu A,cali ozturk h,SOYMAN Z,uysal ö Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. . 2020; 65 - 71. 10.4274/haseki.galenos.2019.5584
IEEE Ates S,Gokmen Karasu A,cali ozturk h,SOYMAN Z,uysal ö "Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women." , ss.65 - 71, 2020. 10.4274/haseki.galenos.2019.5584
ISNAD Ates, Seda vd. "Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women". (2020), 65-71. https://doi.org/10.4274/haseki.galenos.2019.5584
APA Ates S, Gokmen Karasu A, cali ozturk h, SOYMAN Z, uysal ö (2020). Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. Haseki Tıp Bülteni, 58(1), 65 - 71. 10.4274/haseki.galenos.2019.5584
Chicago Ates Seda,Gokmen Karasu Ayse Filiz,cali ozturk halime,SOYMAN ZEYNEP,uysal ömer Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. Haseki Tıp Bülteni 58, no.1 (2020): 65 - 71. 10.4274/haseki.galenos.2019.5584
MLA Ates Seda,Gokmen Karasu Ayse Filiz,cali ozturk halime,SOYMAN ZEYNEP,uysal ömer Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. Haseki Tıp Bülteni, vol.58, no.1, 2020, ss.65 - 71. 10.4274/haseki.galenos.2019.5584
AMA Ates S,Gokmen Karasu A,cali ozturk h,SOYMAN Z,uysal ö Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. Haseki Tıp Bülteni. 2020; 58(1): 65 - 71. 10.4274/haseki.galenos.2019.5584
Vancouver Ates S,Gokmen Karasu A,cali ozturk h,SOYMAN Z,uysal ö Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women. Haseki Tıp Bülteni. 2020; 58(1): 65 - 71. 10.4274/haseki.galenos.2019.5584
IEEE Ates S,Gokmen Karasu A,cali ozturk h,SOYMAN Z,uysal ö "Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women." Haseki Tıp Bülteni, 58, ss.65 - 71, 2020. 10.4274/haseki.galenos.2019.5584
ISNAD Ates, Seda vd. "Factors Associated with Insufficient Endometrial Sampling in Postmenopausal Women". Haseki Tıp Bülteni 58/1 (2020), 65-71. https://doi.org/10.4274/haseki.galenos.2019.5584