HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN

Boy, Fatih; ÇELİK, SEDA; KARA, Fatih; TAŞKIN, Ergin; Yavuz, Duygu Mine

HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN

Seda ÇELİK, (Kafkas Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kars, TÜRKİYE.)

Duygu Mine YAVUZ, (Kafkas Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kars, TÜRKİYE.)

Ergin TAŞKIN, (Kafkas Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kars, TÜRKİYE.)

Fatih BOY, (Kafkas Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kars, TÜRKİYE.)

Fatih KARA (Kafkas Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kars, TÜRKİYE.)

Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi

20 0

Yıl: 2020 Cilt: 21 Sayı: 1 Sayfa Aralığı: 191 - 194 Metin Dili: İngilizce İndeks Tarihi: 14-10-2020

HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN

Öz:

OBJECTIVE: Erythrocyte sedimentation rate (ESR) is a laboratory marker widely used in clinical practice. It is aected primarily by two factors following: plasma proteins such as fibrinogenand some conditions associated with the erythrocytes such ashematocrit. Some formulas have been developed so as to interpret the ESR by eliminating the eect on the ESR of the hematocrit. The purpose of our research was to determine whether the formulas for ESR adjusted with hematocrit levels have abetter correlation with C-reactive protein (CRP).MATERIAL AND METHODS: The data belong to February 2018were obtained from database of our hospital. A total of 1206patients’ results including ESR, CRP, and hematocrit, whichhad been measured in blood samples simultaneously obtained, were analyzed in terms of whether there is a correlationbetween these parameters. Hematocrit-adjusted ESR valueswere calculated by formulas following: (a) Hematocrit-adjustedsedimentation-1 (HA-ESR-1) = [(15)/(55-hematocrit)]X sedimentation, (b) Hematocrit-adjusted sedimentation-2 (HA-ESR-2) =(hematocrit/45)X sedimentation.RESULTS: While HA-ESR-2 had a better correlation with CRPcompared to standard ESR measurements, HA-ESR-1 didn'tmake good the association between CRP and ESR.CONCLUSIONS: We found that HA-ESR-2 has significantly abetter correlation with CRP than that of standard ESR. Therefore,this formula may be useful in clinical practice.

Anahtar Kelime:

HEMATOKRİTE GÖRE DÜZELTİLMİŞ ERİTROSİT SEDİMENTASYON HIZI, C-REAKTİF PROTEİN İLE DAHA İYİ BİR KORELASYONA SAHİPTİR

Öz:

AMAÇ: Eritrosit sedimentasyon hızı (ESR) klinik uygulamada yaygın olarak kullanılan bir laboratuvar belirtecidir. ESR, temel olarak iki faktörden etkilenir: fibrinojen gibi plazma proteinleri ve hematokrit gibi eritrositler ile ilişkili bazı durumlar. Hematokritin ESR üzerindeki etkisini ortadan kaldırarak ESR'yi yorumlayabilmek için bazı formüller geliştirilmiştir. Bu çalışmanın amacı, hematokrite göre düzeltilmiş ESR formüllerinin C-reaktif protein (CRP) ile daha iyi bir korelasyonunun olup olmadığını belirlemekti. GEREÇ VE YÖNTEM: Hastanemiz veri tabanından Şubat 2018'e ait veriler alındı. Aynı anda elde edilen kan örneklerinde ölçülen ESR, CRP ve hematokrit değerlerine ait toplam 1206 hastanın sonuçları, bu parametreler arasında bir korelasyon olup olmadığı açısından analiz edildi. Hematokrite göre düzeltilmiş ESR değerleri, aşağıdaki formüllerle hesaplandı: (a) Hematokrite göre düzeltilmiş sedimentasyon-1 (HA-ESR-1) = [(15)/(55-hematokrit)]X sedimentasyon, (b) Hematokrite göre düzeltilmiş sedimentasyon- 2 (HA-ESR-2) = (hematokrit/45)X sedimentasyon. BULGULAR: HA-ESR-2 standart ESR ölçümlerine kıyasla CRP ile daha iyi bir korelasyona sahipti, ancak HA-ESR-1, CRP ve ESR arasındaki ilişkiyi iyileştiremedi. SONUÇ: HA-ESR-2'nin CRP ile standart ESR'den anlamlı olarak daha iyi bir korelasyon gösterdiğini bulduk. Bu nedenle, söz konusu formül klinik uygulamada yararlı olabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Bray C, Bell LN, Liang H, et al. Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine. WMJ 2016;115:317-21.
2. Erdoğdu Hİ, Atalay E. Relationship between high erythrocyte sedimentation rate and 25-hydroxy vitamin D and C-reactive protein levels. Sakarya Med J 2018;8:798-805.
3. Tunç S, Atagün MI, Neşelioğlu S, Bilgin YY, Başbuğ HS, Erel Ö. Ischemia-modified albumin: a unique marker of global metabolic risk in schizophrenia and mood disorders. Psychiatry and clinical psychopharmacology 2018;1-7.
4. Markanday A. Acute phase reactants in infections: evidence-based review and a guide for clinicians. Open Forum Infect Dis 2015;2:ofv098.
5. Fabry TL. Mechanism of erythrocyte aggregation and sedimentation. Blood 1987;70:1572-6.
6. Choi JW, Fujii T, Fujii N. Corrected neutrophil gelatinase-associated lipocalin (NGAL) level adjusted by the scoring system of an inammation index for screening renal dysfunction in patients with systemic inammation. Ann Clin Lab Sci 2015;45:248-55.
7. Castell JV, Gomez-Lechon MJ, David M, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989;242:237-9.
8. Kotulska A, Kopec-Mędrek M, Grosicka A, Kubicka M, Kucharz EJ. Correlation between erythrocyte sedimentation rate and C-reactive protein level in patients with rheumatic diseases. Reumatologia 2015;53:243-6.
9. Keenan RT, Swearingen CJ, Yazici Y. Erythrocyte sedimentation rate and C-reactive protein levels are poorly correlated with clinical measures of disease activity in rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis patients. Clin Exp Rheumatol 2008;26:814- 9.
10. Fernandes HP, Cesar CL, Barjas-Castro Mde L. Electrical properties of the red blood cell membrane and immunohematological investigation. Rev Bras Hematol Hemoter 2011;33:297-301.
11. Aytekin M. The current use and the evolution of erythrocyte sedimentation rate measurement. MBSJHS 2018;4:17-23.
12. Gram HC. Über die correction der senkungsreaktion für den einuss des zellvolumenprocentes (haemoglobin) und über die normalen grenzen der senkungsreaktion. Acta Med Scandinav 1928;68:108.
13. Rourke MD, Ernstene AC. A method for correcting the erythrocyte sedimentation rate for variatons in the cell volume percentage of blood. J Clin Invest 1930;8(4):545- 59.
14. Wintrobe MM, Landsberg JW. A standardized technique for the blood sedimentation test. Am J Med Sci 1935;189:102–15.
15. Santhanam S, Mani M, Tamilselvam TN, Sankaralingam R. ESR, uric acid and its correlation with disease activity in SLE - Is it myth or reality! Indian Journal of Rheumatology 2015;9:112-3.
16. Borawski J, Mysliwiec M. The hematocrit-corrected erythrocyte sedimentation rate can be useful in diagnosing inammation in hemodialysis patients. Nephron 2001;89:381-3.
17. Girish K. Practical manual of hematology. 1st ed. New Delhi: Jaypee Brothers Publishers; 2011.
18. Poole JCF, Summers GAC. Correction of ESR in anaemia: experimental study based on interchange of cells and plasma between normal and anaemic subjects. BMJ 1952;1:353-6.
19. Balta S, Mikhailidis DP, Demirkol S, Ozturk C, Celik T, Iyisoy A. Endocan: A novel inammatory indicator in cardiovascular disease? Atherosclerosis 2015;243(1):339-43.
20. Rusak A, Jablonska K, Dziegiel P. The role of YKL-40 in a cancerous process. Postepy Hig Med Dosw 2016;70:1286- 99.
21. Azramezani Kopi T, Shahrokh S, Mirzaei S, Asadzadeh Aghdaei H, Amini Kadijani A. The role of serum calprotectin as a novel biomarker in inammatory bowel diseases: a review study. Gastroenterol Hepatol Bed Bench 2019;12(3):183-9.
22. Zhang Y, Xiao G. Prognostic significance of the ratio of fibrinogen and albumin in human malignancies: a meta-analysis. Cancer Manag Res 2019;11:3381-93.
23. Ma L, Zeng A, Chen B, Chen Y, Zhou R. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with systemic lupus erythematosus and their correlation with activity: A meta-analysis. Int Immunopharmacol 2019;76:105949.
24. Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of Systemic immune-inammation index in cancer: A meta-analysis. J Cancer 2018;9(18):3295-302.
25. Gulhar R, Jialal I (Editors). Physiology, Acute Phase Reactants. Treasure Island (FL): StatPearls Publishing, 2019:1-6.

APA	ÇELİK S, Yavuz D, TAŞKIN E, Boy F, KARA F (2020). HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. , 191 - 194.
Chicago	ÇELİK SEDA,Yavuz Duygu Mine,TAŞKIN Ergin,Boy Fatih,KARA Fatih HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. (2020): 191 - 194.
MLA	ÇELİK SEDA,Yavuz Duygu Mine,TAŞKIN Ergin,Boy Fatih,KARA Fatih HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. , 2020, ss.191 - 194.
AMA	ÇELİK S,Yavuz D,TAŞKIN E,Boy F,KARA F HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. . 2020; 191 - 194.
Vancouver	ÇELİK S,Yavuz D,TAŞKIN E,Boy F,KARA F HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. . 2020; 191 - 194.
IEEE	ÇELİK S,Yavuz D,TAŞKIN E,Boy F,KARA F "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN." , ss.191 - 194, 2020.
ISNAD	ÇELİK, SEDA vd. "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN". (2020), 191-194.

APA	ÇELİK S, Yavuz D, TAŞKIN E, Boy F, KARA F (2020). HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 21(1), 191 - 194.
Chicago	ÇELİK SEDA,Yavuz Duygu Mine,TAŞKIN Ergin,Boy Fatih,KARA Fatih HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 21, no.1 (2020): 191 - 194.
MLA	ÇELİK SEDA,Yavuz Duygu Mine,TAŞKIN Ergin,Boy Fatih,KARA Fatih HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, vol.21, no.1, 2020, ss.191 - 194.
AMA	ÇELİK S,Yavuz D,TAŞKIN E,Boy F,KARA F HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2020; 21(1): 191 - 194.
Vancouver	ÇELİK S,Yavuz D,TAŞKIN E,Boy F,KARA F HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi. 2020; 21(1): 191 - 194.
IEEE	ÇELİK S,Yavuz D,TAŞKIN E,Boy F,KARA F "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN." Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi, 21, ss.191 - 194, 2020.
ISNAD	ÇELİK, SEDA vd. "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN". Afyon Kocatepe Üniversitesi Kocatepe Tıp Dergisi 21/1 (2020), 191-194.