OBJECTIVE: We aimed to compare the prayer sign (PS) and palm print (PP) tests for di icult intubation diagnostic tests including open mouth distance, movement of neck and mandibula, thyromental distance, modified Mallampati scores (MMS), and Cormack-Lehane scores (CLS) in patients who required endotracheal intubation for general anesthesia. MATERIAL AND METHODS: Three hundred and thirty patients as ASA I-III status who required endotracheal intubation for general anesthesia were included in this study. Patient’s demographic datas and chronic diseases were recorded. Diagnostic tests including open mouth distance, movement of neck and mandibula, thyromental distance, MMS, PS and PP tests were performed to all patients and recorded. All patients were intubated by an anesthesiologist who has at least two year experience. The kind of laryngoscope and blade, CLS, the necessity of guide, laryngeal mask airway, intubation laryngeal mask airway, fiber optic intubation, and cricoid pressure, the incidence of the di icult intubation were recorded. P <0.05 was considered statistically significant. RESULTS: In our study; the incidence of di icult intubation was 5.2%. Di icult intubation was found higher in patients included in palm print test 2-3 and with positive PS test (p<0.05). A significant relationship was determined between PP test with CLS and MMS (p=0.013, p=0.044,respectively ). The frequency of MMS 3-4 and CLS III-IV was low in patients with positive praying sign (p> 0.05).Sensitivity to di icult intubation was found to be low in both tests (41% and 10%, respectively). CONCLUSIONS: According to our results, PP test can be used as diagnosis of di icult intubation due to its significant relationship with MMS and CLS tests.