The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey
Yıl: 2020 Cilt: 25 Sayı: 3 Sayfa Aralığı: 350 - 355 Metin Dili: İngilizce DOI: 10.5505/ejm.2020.05945 İndeks Tarihi: 17-11-2020
The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey
Öz: Recurrent balanced translocations are generally considered as the main parameter for prognosis in acute myeloid leukemia(AML). In recent years, genetic studies have focused on the ascertaintment of molecular aspects of various oncofusionproteins associated with AML, such as t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, t(9;22) BCR-ABL1 and inv (16)CBFB-MYH11. Therefore, we evaluated AML cases with RT-PCR for known specific genetic abnormalities that could leadto more accurate prognosis.In our study, we retrospectively reviewed the records of 211 cases (59.2% males and 40.8% females). RT-PCR techniquewas performed to identify t(15;17) PML-RARA, t(8;21) RUNX1-RUNX1T1, t(9;22) BCR-ABL1 and inv (16) CBFBMYH11.The most common rearrangement was found to be t (15; 17) (%12.8) followed by t (8; 21) (7.11%), t (9; 22) (7.6%) and inv(16) (1.42%). Also, in two other cases (0.95%) t(15;17) and t(8;21) were seen together. In addition, none of theserearrangement were found in 148 cases (70.14%) with AML.The presence of chromosomal rearrangements are very important in the diagnosis of AML. Therefore, rapid identificationof specific rearrangements during diagnosis is important for prognostic purposes and can help identifying the cause ofleukemogenesis and provide new strategies for the treatment of cases. This study is useful for both in Turkey oncologistsand transplant centers in other regions will be a reference for the future analyzes and epidemiological data.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Gulbay G, yesilada e, ERKURT M, Gozukara Bag H (2020). The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. , 350 - 355. 10.5505/ejm.2020.05945 |
| Chicago | Gulbay Gonca,yesilada elif,ERKURT MEHMET ALI,Gozukara Bag Harika Gozde The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. (2020): 350 - 355. 10.5505/ejm.2020.05945 |
| MLA | Gulbay Gonca,yesilada elif,ERKURT MEHMET ALI,Gozukara Bag Harika Gozde The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. , 2020, ss.350 - 355. 10.5505/ejm.2020.05945 |
| AMA | Gulbay G,yesilada e,ERKURT M,Gozukara Bag H The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. . 2020; 350 - 355. 10.5505/ejm.2020.05945 |
| Vancouver | Gulbay G,yesilada e,ERKURT M,Gozukara Bag H The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. . 2020; 350 - 355. 10.5505/ejm.2020.05945 |
| IEEE | Gulbay G,yesilada e,ERKURT M,Gozukara Bag H "The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey." , ss.350 - 355, 2020. 10.5505/ejm.2020.05945 |
| ISNAD | Gulbay, Gonca vd. "The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey". (2020), 350-355. https://doi.org/10.5505/ejm.2020.05945 |
| APA | Gulbay G, yesilada e, ERKURT M, Gozukara Bag H (2020). The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern Journal of Medicine, 25(3), 350 - 355. 10.5505/ejm.2020.05945 |
| Chicago | Gulbay Gonca,yesilada elif,ERKURT MEHMET ALI,Gozukara Bag Harika Gozde The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern Journal of Medicine 25, no.3 (2020): 350 - 355. 10.5505/ejm.2020.05945 |
| MLA | Gulbay Gonca,yesilada elif,ERKURT MEHMET ALI,Gozukara Bag Harika Gozde The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern Journal of Medicine, vol.25, no.3, 2020, ss.350 - 355. 10.5505/ejm.2020.05945 |
| AMA | Gulbay G,yesilada e,ERKURT M,Gozukara Bag H The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern Journal of Medicine. 2020; 25(3): 350 - 355. 10.5505/ejm.2020.05945 |
| Vancouver | Gulbay G,yesilada e,ERKURT M,Gozukara Bag H The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey. Eastern Journal of Medicine. 2020; 25(3): 350 - 355. 10.5505/ejm.2020.05945 |
| IEEE | Gulbay G,yesilada e,ERKURT M,Gozukara Bag H "The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey." Eastern Journal of Medicine, 25, ss.350 - 355, 2020. 10.5505/ejm.2020.05945 |
| ISNAD | Gulbay, Gonca vd. "The Evaluation of Common Chromosomal Rearrangements and Their Frequencies in Adult Acute Myeloid Leukemia Cases in Malatya Province of Turkey". Eastern Journal of Medicine 25/3 (2020), 350-355. https://doi.org/10.5505/ejm.2020.05945 |
