Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility

Oglak, Süleyman Cemil; Ege, Serhat; ÖZÇELİK OTCU, SERAP MUTLU; obut, mehmet; Kahveci, Bekir; YILDIZ, İsmail; Sakar, Mehmet Nafi

doi:10.5505/ejm.2020.24993

Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility

Süleyman Cemil OĞLAK, (Sağlık Bilimleri Üniversitesi, Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Diyarbakır, Türkiye)

Mehmet Nafi SAKAR, (Memorial Diyarbakır Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Diyarbakır, Türkiye)

Serhat EGE, (Sağlık Bilimleri Üniversitesi, Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Diyarbakır, Türkiye)

Serap Mutlu ÖZÇELİK OTÇU, (Sağlık Bilimleri Üniversitesi, Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Diyarbakır, Türkiye)

Mehmet OBUT, (Etlik Zübeyde Hanım Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Ankara, Türkiye)

Bekir KAHVECİ, (Çukurova Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adana, Türkiye)

İsmail YILDIZ (Dicle Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Diyarbakır, Türkiye)

Eastern Journal of Medicine

19 5

Yıl: 2020 Cilt: 25 Sayı: 3 Sayfa Aralığı: 427 - 433 Metin Dili: İngilizce DOI: 10.5505/ejm.2020.24993 İndeks Tarihi: 17-11-2020

Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility

Öz:

This study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle -stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles.This study consisted of 86 patients who experienced 106 IUI cycle s. Patients were classified into two treatment groups:group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was triggered withhuman chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ≥18 mm, endometrialthickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates,spontaneous abortion rates, and live birth rates were evaluated.The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSHalone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were alsolower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001).Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05).The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and ac ceptable endometrialthickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH alone

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Oglak S, Sakar M, Ege S, ÖZÇELİK OTCU S, obut m, Kahveci B, YILDIZ İ (2020). Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. , 427 - 433. 10.5505/ejm.2020.24993
Chicago	Oglak Süleyman Cemil,Sakar Mehmet Nafi,Ege Serhat,ÖZÇELİK OTCU SERAP MUTLU,obut mehmet,Kahveci Bekir,YILDIZ İsmail Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. (2020): 427 - 433. 10.5505/ejm.2020.24993
MLA	Oglak Süleyman Cemil,Sakar Mehmet Nafi,Ege Serhat,ÖZÇELİK OTCU SERAP MUTLU,obut mehmet,Kahveci Bekir,YILDIZ İsmail Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. , 2020, ss.427 - 433. 10.5505/ejm.2020.24993
AMA	Oglak S,Sakar M,Ege S,ÖZÇELİK OTCU S,obut m,Kahveci B,YILDIZ İ Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. . 2020; 427 - 433. 10.5505/ejm.2020.24993
Vancouver	Oglak S,Sakar M,Ege S,ÖZÇELİK OTCU S,obut m,Kahveci B,YILDIZ İ Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. . 2020; 427 - 433. 10.5505/ejm.2020.24993
IEEE	Oglak S,Sakar M,Ege S,ÖZÇELİK OTCU S,obut m,Kahveci B,YILDIZ İ "Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility." , ss.427 - 433, 2020. 10.5505/ejm.2020.24993
ISNAD	Oglak, Süleyman Cemil vd. "Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility". (2020), 427-433. https://doi.org/10.5505/ejm.2020.24993

APA	Oglak S, Sakar M, Ege S, ÖZÇELİK OTCU S, obut m, Kahveci B, YILDIZ İ (2020). Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. Eastern Journal of Medicine, 25(3), 427 - 433. 10.5505/ejm.2020.24993
Chicago	Oglak Süleyman Cemil,Sakar Mehmet Nafi,Ege Serhat,ÖZÇELİK OTCU SERAP MUTLU,obut mehmet,Kahveci Bekir,YILDIZ İsmail Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. Eastern Journal of Medicine 25, no.3 (2020): 427 - 433. 10.5505/ejm.2020.24993
MLA	Oglak Süleyman Cemil,Sakar Mehmet Nafi,Ege Serhat,ÖZÇELİK OTCU SERAP MUTLU,obut mehmet,Kahveci Bekir,YILDIZ İsmail Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. Eastern Journal of Medicine, vol.25, no.3, 2020, ss.427 - 433. 10.5505/ejm.2020.24993
AMA	Oglak S,Sakar M,Ege S,ÖZÇELİK OTCU S,obut m,Kahveci B,YILDIZ İ Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. Eastern Journal of Medicine. 2020; 25(3): 427 - 433. 10.5505/ejm.2020.24993
Vancouver	Oglak S,Sakar M,Ege S,ÖZÇELİK OTCU S,obut m,Kahveci B,YILDIZ İ Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility. Eastern Journal of Medicine. 2020; 25(3): 427 - 433. 10.5505/ejm.2020.24993
IEEE	Oglak S,Sakar M,Ege S,ÖZÇELİK OTCU S,obut m,Kahveci B,YILDIZ İ "Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility." Eastern Journal of Medicine, 25, ss.427 - 433, 2020. 10.5505/ejm.2020.24993
ISNAD	Oglak, Süleyman Cemil vd. "Comparison of The Efficacy of Letrozole and Gonadotropin Combination Versus Gonadotropin Alone In Intrauterine Insemination Cycles In Patients With Unexplained Infertility". Eastern Journal of Medicine 25/3 (2020), 427-433. https://doi.org/10.5505/ejm.2020.24993