Yıl: 2020 Cilt: 35 Sayı: 2 Sayfa Aralığı: 163 - 166 Metin Dili: İngilizce DOI: doi: 10.5505/tjo.2019.2092 İndeks Tarihi: 17-11-2020

C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma

Öz:
OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial role in the regulation of the cell cycle. Mutations of the p53 gene havean important role in OSCC carcinogenesis. In this study, we aimed to evaluate the C-deletion mutation in exon 4 codon 63 of p53 gene in Turkish patients with OSCC. METHODS A total of 60 subjects were enrolled in this study, 30 patients with a pathologic diagnosis of OSCC and 30 cases of age and sex-matched healthy controls. Genotyping was performed for all individuals using polymerase chain reaction (PCR) analysis. RESULTS CONCLUSION T he findings showed that the distribution of p53 exon 4 codon 63 C-deletion was significantly different between patient group and control group (p=0.000). It was detected that all patients had C-deletion mutation in exon 4 codon 63 of p53. Our results suggest that C-deletion in exon 4 codon 63 deletion of the p53 gene may play a role in the pathogenesis of human OSCC in a Turkish cohort.
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APA TEKCAN A, Gumusay O, Nursal A, Yigit S, Yildiz S, TÜMER M (2020). C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. , 163 - 166. doi: 10.5505/tjo.2019.2092
Chicago TEKCAN AKIN,Gumusay Ozge,Nursal Ayse Feyda,Yigit Serbulent,Yildiz Serkan,TÜMER Mehmet Kemal C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. (2020): 163 - 166. doi: 10.5505/tjo.2019.2092
MLA TEKCAN AKIN,Gumusay Ozge,Nursal Ayse Feyda,Yigit Serbulent,Yildiz Serkan,TÜMER Mehmet Kemal C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. , 2020, ss.163 - 166. doi: 10.5505/tjo.2019.2092
AMA TEKCAN A,Gumusay O,Nursal A,Yigit S,Yildiz S,TÜMER M C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. . 2020; 163 - 166. doi: 10.5505/tjo.2019.2092
Vancouver TEKCAN A,Gumusay O,Nursal A,Yigit S,Yildiz S,TÜMER M C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. . 2020; 163 - 166. doi: 10.5505/tjo.2019.2092
IEEE TEKCAN A,Gumusay O,Nursal A,Yigit S,Yildiz S,TÜMER M "C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma." , ss.163 - 166, 2020. doi: 10.5505/tjo.2019.2092
ISNAD TEKCAN, AKIN vd. "C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma". (2020), 163-166. https://doi.org/doi: 10.5505/tjo.2019.2092
APA TEKCAN A, Gumusay O, Nursal A, Yigit S, Yildiz S, TÜMER M (2020). C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. Türk Onkoloji Dergisi, 35(2), 163 - 166. doi: 10.5505/tjo.2019.2092
Chicago TEKCAN AKIN,Gumusay Ozge,Nursal Ayse Feyda,Yigit Serbulent,Yildiz Serkan,TÜMER Mehmet Kemal C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. Türk Onkoloji Dergisi 35, no.2 (2020): 163 - 166. doi: 10.5505/tjo.2019.2092
MLA TEKCAN AKIN,Gumusay Ozge,Nursal Ayse Feyda,Yigit Serbulent,Yildiz Serkan,TÜMER Mehmet Kemal C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. Türk Onkoloji Dergisi, vol.35, no.2, 2020, ss.163 - 166. doi: 10.5505/tjo.2019.2092
AMA TEKCAN A,Gumusay O,Nursal A,Yigit S,Yildiz S,TÜMER M C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. Türk Onkoloji Dergisi. 2020; 35(2): 163 - 166. doi: 10.5505/tjo.2019.2092
Vancouver TEKCAN A,Gumusay O,Nursal A,Yigit S,Yildiz S,TÜMER M C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma. Türk Onkoloji Dergisi. 2020; 35(2): 163 - 166. doi: 10.5505/tjo.2019.2092
IEEE TEKCAN A,Gumusay O,Nursal A,Yigit S,Yildiz S,TÜMER M "C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma." Türk Onkoloji Dergisi, 35, ss.163 - 166, 2020. doi: 10.5505/tjo.2019.2092
ISNAD TEKCAN, AKIN vd. "C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma". Türk Onkoloji Dergisi 35/2 (2020), 163-166. https://doi.org/doi: 10.5505/tjo.2019.2092