Yıl: 2020 Cilt: 23 Sayı: 6 Sayfa Aralığı: 334 - 341 Metin Dili: İngilizce İndeks Tarihi: 17-11-2020

Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study

Öz:
Objective: Obstructive sleep apnea (OSA) is associated with elevated blood pressure (BP) and increases the risk of developing cardiovasculardiseases. This study aimed to determine the clinical and polysomnographic features of OSA that are significantly associated with hypertension (HT).Methods: This is a prospective study that enrolled patients diagnosed with OSA in Ankara University Faculty of Medicine from January 2015 toJune 2016. The patients were categorized into normotensives (n=125) and hypertensives (n=141). BP was taken at the evening before and themorning after polysomnography (PSG). The polysomnographic findings of normotensive and hypertensive patients were compared, and independent risk factors that are associated with HT were analyzed.Results: Hypertensive patients exhibited older age and higher Epworth sleepiness scale (ESS), apnea–hypopnea index (AHI), mean apnea duration, arousal index, and oxygen desaturation index (ODI) than normotensive patients. Nocturnal oxygen desaturation (NOD) was more frequentand the percentage of the duration of NOD to total sleep time (TST) was higher in hypertensive than normotensive patients. Multivariate analysesrevealed that age (OR: 1.095, 95%CI 1.053 to 1.139, p<0.001), ESS (OR: 1.186, 95%CI 1.071 to 1.313, p=0.001), mean apnea duration (OR: 1.072, 95%CI1.032 to 1.113, p=0.002), ODI (OR: 1.062, 95%CI 1.025 to 1.101, p=0.001), and NOD (OR: 2.439, 95%CI 1.170 to 5.086, p=0.017) were independent riskfactors for HT in OSA.Conclusion: This study suggests that age, ESS, parameters of oxygenation, and apnea duration were associated with HT in patients with OSA.Hence, patients with OSA with these findings should be evaluated for HT. (Anatol J Cardiol 2020; 23: 334-41)
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  • 1. Qaseem A, Dallas P, Owens DK, Starkey M, Holty JE, Shekelle P; Clinical Guidelines Committee of the American College of Physicians. Diagnosis of obstructive sleep apnea in adults: a clinical practice guideline from theAmerican College of Physicians. Ann Intern Med 2014; 161: 210-20.
  • 2. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation 2012; 125: 1635-42.
  • 3. Torres G, Sánchez-de-la-Torre M, Barbé F. Relationship Between OSA and Hypertension. Chest 2015; 148: 824-32.
  • 4. Ahmad M, Makati D, Akbar S. Review of and Updates on Hypertension in Obstructive Sleep Apnea. Int J Hypertens 2017; 2017: 1848375.
  • 5. Wolf J, Hering D, Narkiewicz K. Non-dipping pattern of hypertension and obstructive sleep apnea syndrome. Hypertens Res 2010; 33: 867-71.
  • 6. Legramante JM, Galante A. Sleep and hypertension: a challenge for the autonomic regulation of the cardiovascular system. Circulation 2005; 112: 786-8.
  • 7. Natsios G, Pastaka C, Vavougios G, Zarogiannis SG, Tsolaki V, Dimoulis A, et al. Age, Body Mass Index, and Daytime and Nocturnal Hypoxia as Predictors of Hypertension in Patients With Obstructive Sleep Apnea. J Clin Hypertens (Greenwich) 2016; 18: 146-52.
  • 8. Turgut Celen Y, Peker Y. Cardiovascular consequences of sleep apnea: II-Cardiovascular mechanisms. Anatol J Cardiol 2010; 10: 168-75.
  • 9. Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, et al.; Task Force Members. 2013 ESH/ESC Guidelines for themanagement of arterial hypertension The Task Force for the management ofarterial hypertension of the European Society ofHypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31: 1281-357.
  • 10. Johns MW. Reliability and factor analysis of the Epworth Sleepiness Scale. Sleep 1992; 15: 376-81.
  • 11. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al.; American Academy of Sleep Medicine. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012; 8: 597-619.
  • 12. Iber C, Ancoli-Israel S, Chesson AL Jr., Quan SF; for the American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. 1st ed. Westchester, IL: American Academy of Sleep Medicine, 2007.
  • 13. The AASM Manual for the Scoring of Sleep and Associated Events Summary of Updates in Version 2.1. July 1, 2014. URL; https:// j2vjt3dnbra3ps7ll1clb4q2-wpengine.netdna-ssl.com/wp-content/ uploads/2017/11/Summary-of-Updates-in-v2.1-FINAL.pdf.
  • 14. Ortega Ruiz F, Díaz Lobato S, Galdiz Iturri JB, García Rio F, Güell Rous R, Morante Velez F, et al.; SEPAR. Continuous home oxygen therapy. Arch Bronconeumol 2014; 50: 185-200.
  • 15. Lacasse Y, Sériès F, Martin S, Maltais F. Nocturnal oxygen therapy in patients with chronic obstructive pulmonary disease: A survey of Canadian respirologists. Can Respir J 2007; 14: 343-8.
  • 16. Jhamb M, Unruh M. Bidirectional relationship of hypertension with obstructive sleep apnea. Curr Opin Pulm Med 2014; 20: 558-64.
  • 17. Dewan NA, Nieto FJ, Somers VK. Intermittent Hypoxemia and OSA Implications for Comorbidities. Chest 2015; 147: 266-74.
  • 18. Sforza E, Roche F. Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach. Hypoxia (Auckl) 2016; 4: 99-108.
  • 19. Bosc LV, Resta T, Walker B, Kanagy NL. Mechanisms of intermittent hypoxia induced hypertension. J Cell Mol Med 2010; 14: 3-17.
  • 20. Min HJ, Cho YJ, Kim CH, Kim DH, Kim HY, Choi JI, et al. Clinical Features of Obstructive Sleep Apnea That Determine Its High Prevalence in Resistant Hypertension. Yonsei Med J 2015; 56: 1258-65.
  • 21. Marrone O, Bonsignore MR. Blood-pressure variability in patients with obstructive sleep apnea: current perspectives. Nat Sci Sleep 2018; 10: 229-42.
  • 22. Garcia CE, Drager LF, Krieger EM, Negrão CE, Bortolotto LA, Lorenzi-Filho G, et al. Arousals are frequent and associated with exacerbated blood pressure response in patients with primary hypertension. Am J Hypertens 2013; 26: 617-23.
  • 23. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000; 342: 1378-84.
  • 24. Cano-Pumarega I, Durán-Cantolla J, Aizpuru F, Miranda-Serrano E, Rubio R, Martínez-Null C, et al. Obstructive Sleep Apnea and Systemic Hypertension Longitudinal Study in the General Population: the Vitoria Sleep Cohort. Am J Resp Crit Care 2011; 184: 1299-304.
  • 25. Wu H, Zhan X, Zhao M, Wei Y. Mean apnea-hypopnea duration (but not apnea-hypopnea index) is associated with worse hypertension in patients with obstructive sleep apnea. Medicine (Baltimore) 2016; 95: e5493.
  • 26. Haas DC, Foster GL, Nieto FJ, Redline S, Resnick HE, Robbins JA, et al. Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study. Circulation 2005; 111: 614-21.
  • 27. Wang L, Cai A, Zhang J, Zhong Q, Wang R, Chen J, et al. Association of obstructive sleep apnea plus hypertension and prevalent cardiovascular diseases: A cross-sectional study. Medicine (Baltimore) 2016; 95: e4691.
  • 28. Cano-Pumarega I, Barbé F, Esteban A, Martínez-Alonso M, Egea C, Durán-Cantolla J; Spanish Sleep Network(∗). Sleep Apnea and Hypertension Are There Sex Differences? The Vitoria Sleep Cohort. Chest 2017; 152: 742-50.
  • 29. Diogo LN, Pinto P, Bárbara C, Monteiro EC, Papoila AL. Neck circumference and body mass index as independent predictors of hypertension misclassification in patients suspected of having obstructive sleep apnea. Blood Press Monit 2015; 20: 8-15.
  • 30. Donadio V, Liguori R, Vetrugno R, Contin M, Elam M, Wallin BG, et al. Daytime sympathetic hyperactivity in OSAS is related to excessive daytime sleepiness. J Sleep Res 2007; 16: 327-32.
  • 31. Feng J, He QY, Zhang XL, Chen BY; Sleep Breath Disorder Group, Society of Respiratory Medicine. Epworth Sleepiness Scale may be an indicator for blood pressure profile and prevalence of coronary artery disease and cerebrovascular disease in patients with obstructive sleep apnea. Sleep Breath 2012; 16: 31-40.
  • 32. Goldstein IB, Ancoli-Israel S, Shapiro D. Relationship between daytime sleepiness and blood pressure in healthy older adults. Am J Hypertens 2004; 17: 787-92.
  • 33. Tam W, Ng SS, To KW, Ko FW, Hui DS. The interaction between hypertension and obstructive sleep apnea on subjective daytime sleepiness. J Clin Hypertens (Greenwich) 2019; 21: 390-6.
  • 34. Castro-Diehl C, Roux AVD, Redline S, Seeman T, McKinley P, Sloan R, et al. Sleep Duration and Quality in Relation to Autonomic Nervous System Measures: The Multi-Ethnic Study of Atherosclerosis (MESA). Sleep 2016; 39: 1927-40.
  • 35. The National Institute for Health and Care Excellence (2019). Hypertension in adults: diagnosis and management (NICE Guideline 136) London 2019. Available at; URL; https://www.nice.org.uk/guidance/ng136
APA KAYA A, GÜLBAY B, Acıcan T (2020). Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. , 334 - 341.
Chicago KAYA Aslıhan GÜRÜN,GÜLBAY Banu ERİŞ,Acıcan Turan Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. (2020): 334 - 341.
MLA KAYA Aslıhan GÜRÜN,GÜLBAY Banu ERİŞ,Acıcan Turan Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. , 2020, ss.334 - 341.
AMA KAYA A,GÜLBAY B,Acıcan T Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. . 2020; 334 - 341.
Vancouver KAYA A,GÜLBAY B,Acıcan T Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. . 2020; 334 - 341.
IEEE KAYA A,GÜLBAY B,Acıcan T "Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study." , ss.334 - 341, 2020.
ISNAD KAYA, Aslıhan GÜRÜN vd. "Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study". (2020), 334-341.
APA KAYA A, GÜLBAY B, Acıcan T (2020). Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. The Anatolian Journal of Cardiology, 23(6), 334 - 341.
Chicago KAYA Aslıhan GÜRÜN,GÜLBAY Banu ERİŞ,Acıcan Turan Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. The Anatolian Journal of Cardiology 23, no.6 (2020): 334 - 341.
MLA KAYA Aslıhan GÜRÜN,GÜLBAY Banu ERİŞ,Acıcan Turan Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. The Anatolian Journal of Cardiology, vol.23, no.6, 2020, ss.334 - 341.
AMA KAYA A,GÜLBAY B,Acıcan T Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. The Anatolian Journal of Cardiology. 2020; 23(6): 334 - 341.
Vancouver KAYA A,GÜLBAY B,Acıcan T Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study. The Anatolian Journal of Cardiology. 2020; 23(6): 334 - 341.
IEEE KAYA A,GÜLBAY B,Acıcan T "Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study." The Anatolian Journal of Cardiology, 23, ss.334 - 341, 2020.
ISNAD KAYA, Aslıhan GÜRÜN vd. "Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study". The Anatolian Journal of Cardiology 23/6 (2020), 334-341.