Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study
Yıl: 2019 Cilt: 45 Sayı: 1 Sayfa Aralığı: 22 - 25 Metin Dili: İngilizce DOI: 10.5152/tud.2019.46416 İndeks Tarihi: 07-11-2020
Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study
Öz: Objective: The aim of the present study was to evaluate the predictive value of the serum expression levelof Piwi-like 2 (PIWIL2), a stem cell protein, for prostate cancer (PCa).Materials and method: This randomized and prospective study included a total of 60 volunteers between50 and 75 years old. Cases were assigned to three groups according to prostate-specific antigen (PSA) elevations and pathology reports, with 20 participants in each group. The first group included patients with a PSAlevel of >4 ng/dL and with PCa, the second group included patients with a PSA level of >4 ng/dL and withbenign prostate hyperplasia, and the third group included patients with a PSA level of ≤4 ng/dL and withbenign prostate hyperplasia. The levels of serum PSA and PIWIL2 expressions were compared between thegroups.Results: The median serum PSA levels were 28.5 (4.6–98.1) ng/mL, 8.89 (4.3–24.1) ng/mL, and 2.4 (0.3–3.8) ng/mL for groups 1, 2, and 3, respectively. The PSA levels were significantly different between thegroups (p<0.001). The median PIWIL2 gene expression levels were 2.54 (0.28–9.27), 2.27 (0.6–9.38), and1.17 (0.26–3.07) for groups 1, 2, and 3, respectively. The PIWIL2 gene expression level was found to belower in patients with a PSA level of <4 (p=0.02). No significant difference was observed between patientswith and without cancer among those with a PSA level of ≥4 (p>0.05). Patients diagnosed with cancer weregrouped according to the criteria of the International Society of Urological Pathology (ISUP), and PIWIL2gene expression was observed to be significantly higher among patients with ISUP of >3 than among thosewith ISUP of ≤3 (p=0.04).Conclusion: In our study, it was observed that the serum level of PIWIL2 gene expression could not be adiagnostic indicator of PCa; however, it could be a beneficial prognostic indicator particularly for progresseddisease.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Tosun H, Demirtaş A, Sönmez G, Tombul S, Akalın H, OZKUL Y (2019). Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. , 22 - 25. 10.5152/tud.2019.46416 |
| Chicago | Tosun Halil,Demirtaş Abdullah,Sönmez Gökhan,Tombul Sevket Tolga,Akalın Hilal,OZKUL Yusuf Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. (2019): 22 - 25. 10.5152/tud.2019.46416 |
| MLA | Tosun Halil,Demirtaş Abdullah,Sönmez Gökhan,Tombul Sevket Tolga,Akalın Hilal,OZKUL Yusuf Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. , 2019, ss.22 - 25. 10.5152/tud.2019.46416 |
| AMA | Tosun H,Demirtaş A,Sönmez G,Tombul S,Akalın H,OZKUL Y Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. . 2019; 22 - 25. 10.5152/tud.2019.46416 |
| Vancouver | Tosun H,Demirtaş A,Sönmez G,Tombul S,Akalın H,OZKUL Y Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. . 2019; 22 - 25. 10.5152/tud.2019.46416 |
| IEEE | Tosun H,Demirtaş A,Sönmez G,Tombul S,Akalın H,OZKUL Y "Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study." , ss.22 - 25, 2019. 10.5152/tud.2019.46416 |
| ISNAD | Tosun, Halil vd. "Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study". (2019), 22-25. https://doi.org/10.5152/tud.2019.46416 |
| APA | Tosun H, Demirtaş A, Sönmez G, Tombul S, Akalın H, OZKUL Y (2019). Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. Turkish Journal of Urology, 45(1), 22 - 25. 10.5152/tud.2019.46416 |
| Chicago | Tosun Halil,Demirtaş Abdullah,Sönmez Gökhan,Tombul Sevket Tolga,Akalın Hilal,OZKUL Yusuf Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. Turkish Journal of Urology 45, no.1 (2019): 22 - 25. 10.5152/tud.2019.46416 |
| MLA | Tosun Halil,Demirtaş Abdullah,Sönmez Gökhan,Tombul Sevket Tolga,Akalın Hilal,OZKUL Yusuf Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. Turkish Journal of Urology, vol.45, no.1, 2019, ss.22 - 25. 10.5152/tud.2019.46416 |
| AMA | Tosun H,Demirtaş A,Sönmez G,Tombul S,Akalın H,OZKUL Y Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. Turkish Journal of Urology. 2019; 45(1): 22 - 25. 10.5152/tud.2019.46416 |
| Vancouver | Tosun H,Demirtaş A,Sönmez G,Tombul S,Akalın H,OZKUL Y Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study. Turkish Journal of Urology. 2019; 45(1): 22 - 25. 10.5152/tud.2019.46416 |
| IEEE | Tosun H,Demirtaş A,Sönmez G,Tombul S,Akalın H,OZKUL Y "Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study." Turkish Journal of Urology, 45, ss.22 - 25, 2019. 10.5152/tud.2019.46416 |
| ISNAD | Tosun, Halil vd. "Can the expression level of PIWIL 2 gene be a serum marker for prostate cancer? A single-center prospective study". Turkish Journal of Urology 45/1 (2019), 22-25. https://doi.org/10.5152/tud.2019.46416 |
