The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters

EREL, Ozcan; İÇME, Ferhat; ŞENER, ALP; ercan haydar, fadime güllü; GÜNAYDIN, Gül Pamukçu; OTAL, YAVUZ; Atmaca Temrel, Tuğba; BARAN, PERVİN

doi:10.14744/tjtes.2019.38969

The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters

Fadime Güllü ERCAN HAYDAR, (Atatürk Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, Ankara, Türkiye)

Yavuz OTAL, (Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye)

Alp ŞENER, (Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye)

Gül PAMUKÇU GÜNAYDIN, (Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye)

Ferhat İÇME, (Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye)

Tuğba ATMACA TEMREL, (Atatürk Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Ankara, Türkiye)

Pervin BARAN, (Atatürk Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Özcan EREL (Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye)

Ulusal Travma ve Acil Cerrahi Dergisi

4 0

Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 37 - 42 Metin Dili: İngilizce DOI: 10.14744/tjtes.2019.38969 İndeks Tarihi: 10-11-2020

The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters

Öz:

BACKGROUND: Acute pancreatitis is a common disease seen in emergency departments because of abdominal pain. The presentstudy aims to evaluate the relation between measurements of thiol-disulfide parameters in patients diagnosed with acute pancreatitisand other blood parameters.METHODS: A total of 56 (56%) patients, who were admitted to the emergency department, and 44 (44%) healthy volunteers participated in this study. A total of 100 samples were taken from the participants. Detailed blood samples were taken from the patientsat the time of arrival at the hospital. The thiol-disulfide level in serum was examined using a brand new method that was developedby Erel and Neşelioğlu in the venous blood samples of the patients who were diagnosed with acute pancreatitis during the admission.The data were evaluated in the computer medium.RESULTS: Gallstones were defined as the etiology of AP in 41 patients (73.2%); in one patient, hypertriglyceridemia (1.7%); in fourpatients, alcohol use (7.1%), and idiopathic 10 patients (17.8%). While the blood thiol levels were low, the disulfide levels were high ata significant level. No statistically significant relations were detected between the amylase, lipase, neutrophil lymphocyte ratio (NLR),which are other blood parameters, and thiol-disulfide balance parameters.CONCLUSION: The disruption of the thiol-disulfide balance may play a role in the pathogenesis of acute pancreatitis. In acute pancreatitis, since the thiol level is decreased in the blood, administration of the complementary therapies for this thiol deficiency maycontribute to the treatment of the disease.

Anahtar Kelime:

Akut pankreatitli hastalarda tiyol-disülfit dengesi ve diğer kan parametreleri ile ilişkisi

Öz:

AMAÇ: Akut pankreatit (AP) karın ağrısı nedeniyle acil serviste sıklıkla görülen bir hastalıktır. Bu çalışma AP tanısı konulan hastalarda, kanda tiyoldisülfit parametrelerinin ölçümü ve diğer kan parametreleri ile ilişkisinin değerlendirilmesi amaçlandı. GEREÇ VE YÖNTEM: Çalışmaya acil servise başvuran 56 (%56) hasta ve 44 (%44) sağlıklı gönüllü olmak üzere toplam 100 örnek alındı. Hastalardan geliş anında detaylı kan örnekleri alındı. Akut pankreatit tanısı konan hastaların başvurusu sırasında ki venöz kan örneklerinden Erel ve Neşelioğlu tarafından geliştirilen yepyeni bir yöntemle serumda tiyol-disülfide düzeyi çalışıldı. Veriler bilgisayar ortamında değerlendirildi. BULGULAR: Akut pankreatitin etiyolojisi 41 hastada (%73.2) safra taşı, bir hastada (%1.7) hipertrigliseridemi, dört hastada (% 7.1) alkol kullanımı ve 10 hastada (%17.8) idiyopatik idi. Kan tiyol düzeyleri düşük iken, disülfide düzeyleri anlamlı derecede yüksekti. Diğer kan parametreleri olan amilaz, lipaz, NLR (nötrofil lenfosit oranı) ile tiyol-disülfide dengesi parametreleri arasında istatistiki açıdan anlamlı fark bulunamadı. TARTIŞMA: Akut pankreatit de patogenezde tiyol-disülfit dengesinin bozulması rol oynayabilir. AP’de kanda tiyol düzeyi azaldığından bu tiyol eksikliğini tamamlayıcı tedavilerin verilmesi hastalığın iyileşmesine katkıda bulunabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ercan haydar f, OTAL Y, ŞENER A, GÜNAYDIN G, İÇME F, Atmaca Temrel T, BARAN P, EREL O (2020). The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. , 37 - 42. 10.14744/tjtes.2019.38969
Chicago	ercan haydar fadime güllü,OTAL YAVUZ,ŞENER ALP,GÜNAYDIN Gül Pamukçu,İÇME Ferhat,Atmaca Temrel Tuğba,BARAN PERVİN,EREL Ozcan The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. (2020): 37 - 42. 10.14744/tjtes.2019.38969
MLA	ercan haydar fadime güllü,OTAL YAVUZ,ŞENER ALP,GÜNAYDIN Gül Pamukçu,İÇME Ferhat,Atmaca Temrel Tuğba,BARAN PERVİN,EREL Ozcan The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. , 2020, ss.37 - 42. 10.14744/tjtes.2019.38969
AMA	ercan haydar f,OTAL Y,ŞENER A,GÜNAYDIN G,İÇME F,Atmaca Temrel T,BARAN P,EREL O The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. . 2020; 37 - 42. 10.14744/tjtes.2019.38969
Vancouver	ercan haydar f,OTAL Y,ŞENER A,GÜNAYDIN G,İÇME F,Atmaca Temrel T,BARAN P,EREL O The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. . 2020; 37 - 42. 10.14744/tjtes.2019.38969
IEEE	ercan haydar f,OTAL Y,ŞENER A,GÜNAYDIN G,İÇME F,Atmaca Temrel T,BARAN P,EREL O "The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters." , ss.37 - 42, 2020. 10.14744/tjtes.2019.38969
ISNAD	ercan haydar, fadime güllü vd. "The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters". (2020), 37-42. https://doi.org/10.14744/tjtes.2019.38969

APA	ercan haydar f, OTAL Y, ŞENER A, GÜNAYDIN G, İÇME F, Atmaca Temrel T, BARAN P, EREL O (2020). The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. Ulusal Travma ve Acil Cerrahi Dergisi, 26(1), 37 - 42. 10.14744/tjtes.2019.38969
Chicago	ercan haydar fadime güllü,OTAL YAVUZ,ŞENER ALP,GÜNAYDIN Gül Pamukçu,İÇME Ferhat,Atmaca Temrel Tuğba,BARAN PERVİN,EREL Ozcan The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.1 (2020): 37 - 42. 10.14744/tjtes.2019.38969
MLA	ercan haydar fadime güllü,OTAL YAVUZ,ŞENER ALP,GÜNAYDIN Gül Pamukçu,İÇME Ferhat,Atmaca Temrel Tuğba,BARAN PERVİN,EREL Ozcan The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.1, 2020, ss.37 - 42. 10.14744/tjtes.2019.38969
AMA	ercan haydar f,OTAL Y,ŞENER A,GÜNAYDIN G,İÇME F,Atmaca Temrel T,BARAN P,EREL O The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(1): 37 - 42. 10.14744/tjtes.2019.38969
Vancouver	ercan haydar f,OTAL Y,ŞENER A,GÜNAYDIN G,İÇME F,Atmaca Temrel T,BARAN P,EREL O The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(1): 37 - 42. 10.14744/tjtes.2019.38969
IEEE	ercan haydar f,OTAL Y,ŞENER A,GÜNAYDIN G,İÇME F,Atmaca Temrel T,BARAN P,EREL O "The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.37 - 42, 2020. 10.14744/tjtes.2019.38969
ISNAD	ercan haydar, fadime güllü vd. "The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters". Ulusal Travma ve Acil Cerrahi Dergisi 26/1 (2020), 37-42. https://doi.org/10.14744/tjtes.2019.38969