Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain

Erkan Kılınç, (Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Bolu, Türkiye)
Yaşar Dagistan, (Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Nöroşirurji Anabilim Dalı, Bolu, Türkiye)
Fatma Töre (Biruni Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiye)
Clinical and Experimental Health Sciences
5 0
Yıl: 2018 Cilt: 8 Sayı: 3 Sayfa Aralığı: 196 - 201 Metin Dili: İngilizce DOI: 10.5152/clinexphealthsci.2017.658 İndeks Tarihi: 11-11-2020

Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain

Öz:
Objective: The cranial dura mater contains plenty of mast cells and is principallysupplied by the middle meningeal artery which has a key role in the generation ofheadaches. Neurogenic inflammation caused by perivascular nerve activation anddural vasodilation is held responsible for migraine pain. Dural mast cells contributeneurogenic inflammation and migraine via vasoactive and proinflammatory mediatorsin their secretory granules. In the present study, it was aimed to investigate vasoactiveeffect of mast cell degranulating agent compound 48/80 induced dural mast celldegranulation on the middle meningeal artery and its anterior and posterior branches.Methods: Isolated skulls obtained from male Wistar rats were divided into 2 halves.The skull cavities with intact the dura mater were applied synthetic interstitial fluidfor control group or mast cell degranulating agent compound 48/80 (10 µg/ml) insynthetic interstitial fluid for treated group at 37 oC for 15 min. Diameters of middlemeningeal artery and its anterior and posterior branches were measured and mastcells were counted from whole-mount preparations of meningeal dura mater.Results: While compound 48/80 induced massive degranulation of dural mast cells(P<0.01), it did not change the number of mast cells in the dura mater. Moreover,compound 48/80 increased diameter of middle meningeal artery (P<0.01) andits anterior (P<0.05) and posterior (P<0.01) branches, respectively compared tosynthetic interstitial fluid treatment.Conclusion: Dural mast cell degranulation causes dilatation of middle meningealartery which is involved in the pathophysiology of migraine, therefore testing of mastcell stabilizing agents in vivo models of migraine pain may promise hope for the nextbig things in the treatment of migraine headaches.
Anahtar Kelime:

Mast Hücre Degranülasyonu Compound 48/80 ile Tetiklenmiş Migren Ağrısının Altında Yatan Meningeal Vazodilatasyona Aracılık Ediyor

Öz:
Amaç: Kraniyal dura mater çok sayıda mast hücresi barındırmaktadır ve başlıca baş ağrılarının oluşumunda önemli bir role sahip olan middle meningeal arter tarafından beslenmektedir. Migren baş ağrısı oluşumunda, perivasküler sinir aktivasyonu ve dural vazodilatasyonun yol açtığı nörojenik enflamasyon sorumlu tutulmaktadır. Dural mast hücreleri sekretuar granüllerinde bulunan vazoaktif ve proinflamatuar mediyatörler aracılığıyla nörojenik enflamasyon ve migrene katkıda bulunmaktadır. Sunulan çalışmada bir mast hücre degranülatörü olan compound-48/80 ile oluşturulan dural mast hücre degranülasyonunun middle meningeal arter ve bunun anterior ve posterior dalları üzerine vazoaktif etkisinin araştırılması amaçlanmıştır. Yöntemler: Wistar erkek sıçanlardan elde edilen izole kranyumlar iki yarıya bölündü. Dura materi sağlam hemi-kranyumların boşluğuna kontrol grubu için 37 oC’ de yapay interstisyel sıvı ve çalışma grubu için bir mast hücre degranüle edici madde olan compound-48/80 (10 µg/ml) 15 dakika uygulandı. Middle meningeal arter ve bunun anterior ve posterior dallarının çapları ölçüldü ve meningeal dura mater preparasyonlarından mast hücreleri sayıldı. Bulgular: Compound-48/80 dural mast hücrelerinin kitlesel degranülasyonunu tetiklerken (P<0.01), dura materdeki mast hücre sayısını değiştirmedi. Ayrıca compound-48/80, yapay interstisyel sıvı uygulaması ile karşılaştırıldığında, sırasıyla middle meningeal arter (P<0.01) ve bunun anterior (P<0.05) ve posterior (P<0.01) dallarının çaplarını artırdı. Sonuç: Dural mast hücre degranülasyonu migren patofizyolojisi ile ilişkili olan middle meningeal arter dilatasyonuna neden olmaktadır böylece, mast hücre stabilizatörlerinin in vivo migren modellerinde test edilmesi migren baş ağrılarının tedavisinde bir sonraki adım için umut vaadedici olabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kilinc E, DAGİSTAN Y, Töre F (2018). Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. , 196 - 201. 10.5152/clinexphealthsci.2017.658
Chicago Kilinc Erkan,DAGİSTAN Yaşar,Töre Fatma Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. (2018): 196 - 201. 10.5152/clinexphealthsci.2017.658
MLA Kilinc Erkan,DAGİSTAN Yaşar,Töre Fatma Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. , 2018, ss.196 - 201. 10.5152/clinexphealthsci.2017.658
AMA Kilinc E,DAGİSTAN Y,Töre F Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. . 2018; 196 - 201. 10.5152/clinexphealthsci.2017.658
Vancouver Kilinc E,DAGİSTAN Y,Töre F Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. . 2018; 196 - 201. 10.5152/clinexphealthsci.2017.658
IEEE Kilinc E,DAGİSTAN Y,Töre F "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain." , ss.196 - 201, 2018. 10.5152/clinexphealthsci.2017.658
ISNAD Kilinc, Erkan vd. "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain". (2018), 196-201. https://doi.org/10.5152/clinexphealthsci.2017.658
APA Kilinc E, DAGİSTAN Y, Töre F (2018). Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences, 8(3), 196 - 201. 10.5152/clinexphealthsci.2017.658
Chicago Kilinc Erkan,DAGİSTAN Yaşar,Töre Fatma Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences 8, no.3 (2018): 196 - 201. 10.5152/clinexphealthsci.2017.658
MLA Kilinc Erkan,DAGİSTAN Yaşar,Töre Fatma Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences, vol.8, no.3, 2018, ss.196 - 201. 10.5152/clinexphealthsci.2017.658
AMA Kilinc E,DAGİSTAN Y,Töre F Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences. 2018; 8(3): 196 - 201. 10.5152/clinexphealthsci.2017.658
Vancouver Kilinc E,DAGİSTAN Y,Töre F Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain. Clinical and Experimental Health Sciences. 2018; 8(3): 196 - 201. 10.5152/clinexphealthsci.2017.658
IEEE Kilinc E,DAGİSTAN Y,Töre F "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain." Clinical and Experimental Health Sciences, 8, ss.196 - 201, 2018. 10.5152/clinexphealthsci.2017.658
ISNAD Kilinc, Erkan vd. "Mast Cell Degranulation Mediates Compound 48/80-Induced Meningeal Vasodilatation Underlying Migraine Pain". Clinical and Experimental Health Sciences 8/3 (2018), 196-201. https://doi.org/10.5152/clinexphealthsci.2017.658
Sayfa Oluşturulma Tarihi
17-04-2024 16:59

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