Objective: To determine the phlebitis prevalence and affecting factors and the knowledge of nurses on evidence-based practices related to avoiding peripheric venous catheter (PVC) associated infections in surgical clinics. Material and Methods: This cross-sectional prospective observational point prevalence study was conducted in adult surgical wards of a training and research hospital, in June-March 2019. The sample consisted of 103 patients with peripheric venous catheter and 159 nurses working in surgical clinics. The data was collected by “Phlebitis Scale”, “Questionnaire for Avoiding Infections Associated with PVC” and data collection forms developed by researchers. Results: Mean age of patients was 51.17±19.60 years and 59.2% (n=61) were male. Phlebitis associated with peripheric venous catheter prevalence was 24.3% (n=25). Phlebitis frequency was higher in patients who were given intravenous antibiotics (p=0.003), who were given total parenteral nutrition solution (p=0.001), who had multiple interventions on the same vein (p=0.027). Phlebitis frequency was higher in patients with higher mean age (p=0.023) and patients who had longer mean catheterization time (p=0.001). Mean age of nurses was 38.21±17.69 years and the majority of them (71.7%, n=114) had bachelor’s degree. In assessment of knowledge of nurses on avoiding phlebitis, mean correct answer was 4.51±1.67 over 10 questions. Conclusion: It is found that in the surgical clinics one fourth of patients with PVC had phlebitis symptoms associated with PVC and the knowledge of nurses on evidence-based practices for avoiding PVC associated infections was not at desired levels.