Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review

BEHBAHANİ, Soroor; SHAHRAM, Farhad

doi:doi: 10.5543/tkda.2019.21112

Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review

Soroor BEHBAHANİ, (Islamic Azad University, Department of Electrical Engineering, Garmsar Branch, Garmsar, Iran)

Farhad SHAHRAM (Tehran University of Medical Sciences, Shariati Hospital, Rheumatology Research Center, Tehran, Iran)

Türk Kardiyoloji Derneği Arşivi

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Yıl: 2020 Cilt: 48 Sayı: 3 Sayfa Aralığı: 312 - 327 Metin Dili: İngilizce DOI: doi: 10.5543/tkda.2019.21112 İndeks Tarihi: 15-11-2020

Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review

Öz:

The aim of this article was to summarize current knowledge about the potential clinical utility of electrocardiogram (ECG) and heart rate variability (HRV) measures in patients with 4 common autoimmune diseases (ADs): rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Behcet’s disease (BD), and systemic sclerosis (SSc). A search was conducted of the PubMed, Embase, and Scopus databases using terms and a controlled vocabulary associated with these ADs, ECG, and HRV. The available, fulltext articles published in English were considered. In all, 20 publications that examined the direct effect of these diseases on the heart were selected according to a systematic review protocol. Time-frequency domain analysis revealed that HRV parameters were lower in patients with the selected ADs in comparison with control groups. An increased QT dispersion and heart rate corrected QT, which are well-known as risk factors for sudden cardiac death, were observed in the patient group. In some studies, a correlation was seen between the duration of the disease and its activity, while others did not report such an association. Heart rate turbulence parameters were also examined. Turbulence onset was increased in SLE and SSc patients, while the turbulence slope was decreased in SLE patients. There was no significant change in these parameters in BD patients. Patients with ADs demonstrate abnormal HRV and ECG parameters, which indicates an autonomic cardiac functional impairment. Measurement of these parameters can be a useful clinical tool in the diagnosis and prediction of some disorders in patients with ADs. Both of these signals can provide helpful information for physicians to trace the efficacy of prescribed medicines.

Anahtar Kelime:

Yaygın otoimmün hastalığı olan hastalarda elektrokardiyogram ve kalp hızı değişkenliği değerlendirmesi: Metodolojik bir inceleme

Öz:

Bu makalenin amacı, dört yaygın otoimmün hastalığı olan hastalarda elektrokardiyogram (EKG) ve kalp hızı değişkenliği (HRV) ölçümlerinin potansiyel klinik faydası hakkında güncel bilgileri özetlemektir: Dahil edilen hastalıklar içerisinde romatoid artrit (RA), sistemik lupus eritematozus (SLE), Behçet hastalığı (BH) ve sistemik skleroz (SSc) yer almaktadır. Otoimmün hastalıklar, EKG, HRV ile ilişkili terimler kontrollü bir kelime haznesi kullanılarak PubMed, Embase ve Scopus veritabanlarında arama yapıldı. İngilizce olarak yayınlanan tam metin ve makaleler dikkate alındı. Hastalıkların kalp üzerindeki doğrudan etkisini inceleyen 20 yayının hepsi sistematik bir inceleme protokolüne göre seçildi. Zaman frekansı alan analizi, seçili otoimmün hastalığı olan hastalarda HRV parametrelerinin kontrol gruplarına göre daha düşük olduğunu ortaya koydu. Hasta grubunda, ani kardiyak ölüm için risk faktörleri olarak bilinen QT dispersiyonu ve kalp hızına göre düzeltilmiş QT (QTc) artışı gözlendi. Bazı çalışmalarda, hastalığın süresi ile aktivitesi arasında bir korelasyon görülürken, diğerleri için böyle bir ilişki rapor edilmedi. Kalp hızı türbülans parametreleri de incelendi. SLE ve SSc hastalarında türbülans başlangıcı yüksekken, SLE hastalarında türbülans eğimi azdı. BH hastalarında bu parametrelerde anlamlı bir değişiklik yoktu. Otoimmün hastalığı bulunanlar, otonomik kalp fonksiyon bozukluğunu gösteren anormal HRV ve EKG parametreleri gösterir. Bu parametrelerin ölçümü, otoimmün hastalığı olgularında, bazı bozuklukların tanı ve tahmininde faydalı bir klinik araç olabilir. Bu sinyallerin her ikisi de doktorlara reçeteli ilaçların etkinliğini izlemeleri için yardımcı bilgiler sağlayabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	BEHBAHANİ S, SHAHRAM F (2020). Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. , 312 - 327. doi: 10.5543/tkda.2019.21112
Chicago	BEHBAHANİ Soroor,SHAHRAM Farhad Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. (2020): 312 - 327. doi: 10.5543/tkda.2019.21112
MLA	BEHBAHANİ Soroor,SHAHRAM Farhad Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. , 2020, ss.312 - 327. doi: 10.5543/tkda.2019.21112
AMA	BEHBAHANİ S,SHAHRAM F Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. . 2020; 312 - 327. doi: 10.5543/tkda.2019.21112
Vancouver	BEHBAHANİ S,SHAHRAM F Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. . 2020; 312 - 327. doi: 10.5543/tkda.2019.21112
IEEE	BEHBAHANİ S,SHAHRAM F "Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review." , ss.312 - 327, 2020. doi: 10.5543/tkda.2019.21112
ISNAD	BEHBAHANİ, Soroor - SHAHRAM, Farhad. "Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review". (2020), 312-327. https://doi.org/doi: 10.5543/tkda.2019.21112

APA	BEHBAHANİ S, SHAHRAM F (2020). Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. Türk Kardiyoloji Derneği Arşivi, 48(3), 312 - 327. doi: 10.5543/tkda.2019.21112
Chicago	BEHBAHANİ Soroor,SHAHRAM Farhad Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. Türk Kardiyoloji Derneği Arşivi 48, no.3 (2020): 312 - 327. doi: 10.5543/tkda.2019.21112
MLA	BEHBAHANİ Soroor,SHAHRAM Farhad Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. Türk Kardiyoloji Derneği Arşivi, vol.48, no.3, 2020, ss.312 - 327. doi: 10.5543/tkda.2019.21112
AMA	BEHBAHANİ S,SHAHRAM F Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. Türk Kardiyoloji Derneği Arşivi. 2020; 48(3): 312 - 327. doi: 10.5543/tkda.2019.21112
Vancouver	BEHBAHANİ S,SHAHRAM F Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review. Türk Kardiyoloji Derneği Arşivi. 2020; 48(3): 312 - 327. doi: 10.5543/tkda.2019.21112
IEEE	BEHBAHANİ S,SHAHRAM F "Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review." Türk Kardiyoloji Derneği Arşivi, 48, ss.312 - 327, 2020. doi: 10.5543/tkda.2019.21112
ISNAD	BEHBAHANİ, Soroor - SHAHRAM, Farhad. "Electrocardiogram and heart rate variability assessment in patients with common autoimmune diseases: a methodological review". Türk Kardiyoloji Derneği Arşivi 48/3 (2020), 312-327. https://doi.org/doi: 10.5543/tkda.2019.21112