Objectives: The aim of our study was to compare the efficacy of intermittent pneumatic compression on venous hemodynamics in individuals withdifferent body mass indexes (BMIs).Materials and Methods: The study included a total of 48 healthy volunteers. The participants were classified into three groups according to theirBMIs as <24.9 kg/m2 (group I), 25-29.9 kg/m2 (group II), and >30 kg/m2 (group III). The measurements of pulse, arterial blood pressure and oxygensaturation were made, and venous ultrasonography was performed by the investigator. The measurements were repeated at the 30th minute ofintermittent pneumatic compression. Vena femoralis communis (common femoral vein) (VFC) vein flow dynamics were evaluated 1-1.5 cm proximalto the junction of the VFC and great saphenous vein.Results: The increases observed in the peak systolic flow rates of both right and left VFC in groups I and II were found to be significantly highercompared to those observed in group III at the 30th minute of intermittent pneumatic compression application. (p<0.001, p=0.012, and p=0.049,respectively)Conclusion: We demonstrated that intermittent pneumatic compression application increased the femoral venous flow; however, this effectchanged among individuals with different BMIs. We believe that BMI should be considered as an independent risk factor in patients for whomvenous thromboembolism prophylaxis has been planned, which is frequently encountered in emergency units, and that providing the same effectin individuals with different physical properties is important in planning the prophylaxis.