Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity

Oznur AKBAL (Hacettepe Üniversitesi, İleri Teknoloji Uygulama ve Araştırma Merkezi,Ankara, Türkiye)
Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi
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Yıl: 2020 Cilt: 24 Sayı: 1 Sayfa Aralığı: 169 - 177 Metin Dili: İngilizce DOI: 10.19113/sdufenbed.660323 İndeks Tarihi: 15-11-2020

Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity

Öz:
Composite nanoparticles obtained increasing interest because of their scientificandcurativeimportance.Herein,sericin-montmorillonitecomposite nanoparticles(Ser-MtNPs)weresynthesizedbytakingadvantageofthe biodegradability and functional surface diversity of sericin, and biocompatibility and high adsorption properties of montmorillonite as natural resources. The compositenanoparticlewasobtainedby thedesolvationtechniqueand crosslinked with glutaraldehyde for the first time. Doxorubicin was selected to be used as a model anticancer drug to perform the loading and release studies. After chemical and morphological characterization studies with various methods such as Fourier Transform Infra-Red Spectroscopy and Electron Microscopy, the cytotoxic effect of Ser-Mt composite NPs were quanlitatively and quantitatively evaluated on HepG2 (human liver cancer cell line) cells. The results obviously exhibited that high drug loading capacity, sustainable drug release property and its effect on cancer cells made Ser-Mt composite NPs as a good candidate as a drug delivery systemoncancertherapywithmonodisperse,smallaveragesizeandgood polydispersity index.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA AKBAL Ö (2020). Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. , 169 - 177. 10.19113/sdufenbed.660323
Chicago AKBAL ÖZNUR Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. (2020): 169 - 177. 10.19113/sdufenbed.660323
MLA AKBAL ÖZNUR Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. , 2020, ss.169 - 177. 10.19113/sdufenbed.660323
AMA AKBAL Ö Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. . 2020; 169 - 177. 10.19113/sdufenbed.660323
Vancouver AKBAL Ö Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. . 2020; 169 - 177. 10.19113/sdufenbed.660323
IEEE AKBAL Ö "Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity." , ss.169 - 177, 2020. 10.19113/sdufenbed.660323
ISNAD AKBAL, ÖZNUR. "Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity". (2020), 169-177. https://doi.org/10.19113/sdufenbed.660323
APA AKBAL Ö (2020). Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 24(1), 169 - 177. 10.19113/sdufenbed.660323
Chicago AKBAL ÖZNUR Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24, no.1 (2020): 169 - 177. 10.19113/sdufenbed.660323
MLA AKBAL ÖZNUR Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol.24, no.1, 2020, ss.169 - 177. 10.19113/sdufenbed.660323
AMA AKBAL Ö Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020; 24(1): 169 - 177. 10.19113/sdufenbed.660323
Vancouver AKBAL Ö Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020; 24(1): 169 - 177. 10.19113/sdufenbed.660323
IEEE AKBAL Ö "Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity." Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 24, ss.169 - 177, 2020. 10.19113/sdufenbed.660323
ISNAD AKBAL, ÖZNUR. "Sericin-Montmorillonite Composite Nanoparticles as Drug Delivery System in Human Liver Cancer: Development, Drug Release, Cellular Uptake and Cytotoxicity". Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24/1 (2020), 169-177. https://doi.org/10.19113/sdufenbed.660323
Sayfa Oluşturulma Tarihi
17-04-2024 17:6

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