Association between inflammatory markers and primary hyperparathyroidism
Yıl: 2019 Cilt: 3 Sayı: 3 Sayfa Aralığı: 241 - 247 Metin Dili: İngilizce DOI: 10.30565/medalanya.568224 İndeks Tarihi: 15-11-2020
Association between inflammatory markers and primary hyperparathyroidism
Öz: Aim: Primary hyperparathyroidism (PHP) is associated with systemic inflam-mation.The effect of parathyroidectomy (PTX) on inflammatory markers is contro-versial.The aim of our study was to investigate changes in inflammatory markers includingC-reactive protein (hs-CRP), platelet-to-lymphocyte ratio (PLR), and red celldistribution width (RDW) before and after PTX.Patients and Methods: PHP patients (n=55) and age and sex matched healthycontrols (n=50) were included in the study. The clinical and laboratory results of thePHP and control groups were compared before PTX and 6-months after PTX.Results: At baseline, serum hs-CRP (4.01±3.44 vs. 2.48±1.73 mg/L), PLR(127.21±25.77 vs. 103.63±32.52), RDW (15.50±2.53 % vs. 13.49±0.70 %) valueswere higher in the PHP group than in the control group (p<0.05). After PTX, hs-CRP(3.59±3.07 mg/L), PLR (123.03±31.94), RDW (14.25±1.51 %) values did not change(p>0.05). Post-PTX hs-CRP, PLR, and RDW values were higher in the PHP groupthan in the control group (p<0.05). PTH value was positively correlated with pre-PTXhs-CRP (r2=0.377, p=0.001), PLR (r2=0.234, p=0.023), RDW (r2=0.296, p=0.004).Conclusion: Before PTX, inflammatory markers were higher in PHP patients compared with healthy controls. After PTX, the inflammatory markers did not significantlydecrease; however these postoperative markers were higher than controls. İnflammation occurs in PHP patients, and also shows a partial recovery from inflammationdespite successful surgery
Anahtar Kelime: İnflamatuar belirteçler ve primer hiperparatiroidi arasındaki ilişki
Öz: Amaç: Primer hiperparatiroidizm (PHP) sistemik inflamasyonla ilişkilidir. Paratiroidektominin (PTX) inflamatuar b elirteçler ü zerindeki e tkisi tartışmalıdır. Çalışmamızın amacı, PTX öncesi ve sonrası C-reaktif protein (hs-CRP), trombosit / lenfosit oranı (TLO) ve kırmızı hücre dağılım genişliğini (RDW) içeren inflamatuar belirteçlerdeki değişiklikleri araştırmaktı. Hastalar ve Yöntem: Çalışmaya PHP hastaları (n=55) ve yaş ve cinsiyet eşleştirilmiş sağlıklı kontroller (n=50) dahil edildi. PHP ve kontrol gruplarının klinik ve laboratuar sonuçları PTX'den önce ve PTX’den 6 ay sonra karşılaştırıldı. Bulgular: Başlangıçta, serum hs-CRP (4,01±3,44’e karşın 2,48±1,73 mg/L), TLO (127,21±25,77’e karşın 103,63±32,52), RDW (15,50±2,53’e karşın 13,49±0,70 %) değerleri PHP grubunda, kontrol grubundan daha yüksekti (p<0,05). PTX’ten sonra, hs-CRP (3,59±3,07 mg/L), TLO (123,03±31,94), RDW (14,25±1,51 %) değerleri değişmedi (p>0,05). PTX sonrası hs-CRP, TLO ve RDW değerleri PHP grubunda, kontrol grubundan daha yüksekti (p<0,05). PTH değeri, PTX öncesi hs-CRP (r2=0,377, p=0,001), TLO (r2=0,234, p=0,023), RDW (r2=0,296, p=0,004) ile pozitif olarak korele idi. Sonuç: PTX’den önce, PHP hastalarında inflamatuar belirteçler sağlıklı kontrollere kıyasla daha yüksekti. PTX'ten sonra, inflamatuar belirteçler istatiksel anlamlı azalmadı; ancak bu ameliyat sonrası belirteçler kontrollerden daha yüksekti. İnflamasyon PHP hastalarında görülür ve aynı zamanda başarılı bir ameliyat olmasına rağmen inflamasyondan kısmen iyileşme gösterir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Beysel S, ÇALIŞKAN M, Kizilgul M, Çilekar M, ÖZBEK M, ÇAKAL E (2019). Association between inflammatory markers and primary hyperparathyroidism. , 241 - 247. 10.30565/medalanya.568224 |
| Chicago | Beysel Selvihan,ÇALIŞKAN Muhammed Mustafa Tuncer,Kizilgul Muhammed,Çilekar Murat,ÖZBEK Mustafa Cem,ÇAKAL Erman Association between inflammatory markers and primary hyperparathyroidism. (2019): 241 - 247. 10.30565/medalanya.568224 |
| MLA | Beysel Selvihan,ÇALIŞKAN Muhammed Mustafa Tuncer,Kizilgul Muhammed,Çilekar Murat,ÖZBEK Mustafa Cem,ÇAKAL Erman Association between inflammatory markers and primary hyperparathyroidism. , 2019, ss.241 - 247. 10.30565/medalanya.568224 |
| AMA | Beysel S,ÇALIŞKAN M,Kizilgul M,Çilekar M,ÖZBEK M,ÇAKAL E Association between inflammatory markers and primary hyperparathyroidism. . 2019; 241 - 247. 10.30565/medalanya.568224 |
| Vancouver | Beysel S,ÇALIŞKAN M,Kizilgul M,Çilekar M,ÖZBEK M,ÇAKAL E Association between inflammatory markers and primary hyperparathyroidism. . 2019; 241 - 247. 10.30565/medalanya.568224 |
| IEEE | Beysel S,ÇALIŞKAN M,Kizilgul M,Çilekar M,ÖZBEK M,ÇAKAL E "Association between inflammatory markers and primary hyperparathyroidism." , ss.241 - 247, 2019. 10.30565/medalanya.568224 |
| ISNAD | Beysel, Selvihan vd. "Association between inflammatory markers and primary hyperparathyroidism". (2019), 241-247. https://doi.org/10.30565/medalanya.568224 |
| APA | Beysel S, ÇALIŞKAN M, Kizilgul M, Çilekar M, ÖZBEK M, ÇAKAL E (2019). Association between inflammatory markers and primary hyperparathyroidism. Acta Medica Alanya, 3(3), 241 - 247. 10.30565/medalanya.568224 |
| Chicago | Beysel Selvihan,ÇALIŞKAN Muhammed Mustafa Tuncer,Kizilgul Muhammed,Çilekar Murat,ÖZBEK Mustafa Cem,ÇAKAL Erman Association between inflammatory markers and primary hyperparathyroidism. Acta Medica Alanya 3, no.3 (2019): 241 - 247. 10.30565/medalanya.568224 |
| MLA | Beysel Selvihan,ÇALIŞKAN Muhammed Mustafa Tuncer,Kizilgul Muhammed,Çilekar Murat,ÖZBEK Mustafa Cem,ÇAKAL Erman Association between inflammatory markers and primary hyperparathyroidism. Acta Medica Alanya, vol.3, no.3, 2019, ss.241 - 247. 10.30565/medalanya.568224 |
| AMA | Beysel S,ÇALIŞKAN M,Kizilgul M,Çilekar M,ÖZBEK M,ÇAKAL E Association between inflammatory markers and primary hyperparathyroidism. Acta Medica Alanya. 2019; 3(3): 241 - 247. 10.30565/medalanya.568224 |
| Vancouver | Beysel S,ÇALIŞKAN M,Kizilgul M,Çilekar M,ÖZBEK M,ÇAKAL E Association between inflammatory markers and primary hyperparathyroidism. Acta Medica Alanya. 2019; 3(3): 241 - 247. 10.30565/medalanya.568224 |
| IEEE | Beysel S,ÇALIŞKAN M,Kizilgul M,Çilekar M,ÖZBEK M,ÇAKAL E "Association between inflammatory markers and primary hyperparathyroidism." Acta Medica Alanya, 3, ss.241 - 247, 2019. 10.30565/medalanya.568224 |
| ISNAD | Beysel, Selvihan vd. "Association between inflammatory markers and primary hyperparathyroidism". Acta Medica Alanya 3/3 (2019), 241-247. https://doi.org/10.30565/medalanya.568224 |
