Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice

Mehmet Yalçın GÜNAL, (Alanya Alaaddin Keykubat Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Antalya, Türkiye)
Seyda ÇANKAYA, (Alanya Alaaddin Keykubat Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Antalya, Türkiye)
Şükrü Burak TÖNÜK, (Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Bolu, Türkiye)
Ekrem Musa ÖZDEMİR, (İstanbul Medipol Üniversitesi, Hayvan Tesisleri Bölümü, İstanbul, Türkiye)
Ayşe Arzu SAYIN ŞAKUL (Rejeneratif ve Restoratif Tıp Araştırma Merkezi (REMER), İstanbul Medipol Üniversitesi, İstanbul, Türkiye)
Acta Medica Alanya
3 0
Yıl: 2019 Cilt: 3 Sayı: 3 Sayfa Aralığı: 306 - 310 Metin Dili: İngilizce DOI: 10.30565/medalanya.632455 İndeks Tarihi: 16-11-2020

Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice

Öz:
Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.
Anahtar Kelime:

Adalimumab'ın Farelerde Deneysel Beyin Hasarına Etkisinin Araştırılması

Öz:
Amaç: “TNF-alfa inhibitörü Adalimumab’ın, anti-inflamatuvar etkisi nedeniyle inflamasyonla ilişkili nöronal hasarı etkileyebileceği” hipotezine dayanarak adalimumab’ın nöroprotektif rolünü araştırmayı amaçladık. Metotlar: Adalimumab’ın etkilerini araştırmak için soğuk travma modelini kullanarak farelerde beyin hasarı oluşturduk ve krezil viyole boyasıyla hücre sağ-kalım/ölüm oranları ile görüntü analiz sistemi ile hesaplanan infarktüs/ödem hacmini değerlendirdik. Bulgular: Verilerimiz infarkt ve ödem hacminde azalma eğilimi göstermesine rağmen istatistiksel olarak anlamlı değildir. Sonuç: Bildiğimiz kadarıyla çalışmamız adalimumab’ın hasarlı nöronlar üzerindeki nöroprotektif etkisini değerlendiren ilk çalışmadır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA gunal m, ÇANKAYA S, TÖNÜK Ş, ÖZDEMİR E, SAYIN ŞAKUL A (2019). Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. , 306 - 310. 10.30565/medalanya.632455
Chicago gunal mehmet yalcin,ÇANKAYA Seyda,TÖNÜK Şükrü Burak,ÖZDEMİR EKREM MUSA,SAYIN ŞAKUL Ayşe Arzu Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. (2019): 306 - 310. 10.30565/medalanya.632455
MLA gunal mehmet yalcin,ÇANKAYA Seyda,TÖNÜK Şükrü Burak,ÖZDEMİR EKREM MUSA,SAYIN ŞAKUL Ayşe Arzu Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. , 2019, ss.306 - 310. 10.30565/medalanya.632455
AMA gunal m,ÇANKAYA S,TÖNÜK Ş,ÖZDEMİR E,SAYIN ŞAKUL A Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. . 2019; 306 - 310. 10.30565/medalanya.632455
Vancouver gunal m,ÇANKAYA S,TÖNÜK Ş,ÖZDEMİR E,SAYIN ŞAKUL A Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. . 2019; 306 - 310. 10.30565/medalanya.632455
IEEE gunal m,ÇANKAYA S,TÖNÜK Ş,ÖZDEMİR E,SAYIN ŞAKUL A "Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice." , ss.306 - 310, 2019. 10.30565/medalanya.632455
ISNAD gunal, mehmet yalcin vd. "Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice". (2019), 306-310. https://doi.org/10.30565/medalanya.632455
APA gunal m, ÇANKAYA S, TÖNÜK Ş, ÖZDEMİR E, SAYIN ŞAKUL A (2019). Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. Acta Medica Alanya, 3(3), 306 - 310. 10.30565/medalanya.632455
Chicago gunal mehmet yalcin,ÇANKAYA Seyda,TÖNÜK Şükrü Burak,ÖZDEMİR EKREM MUSA,SAYIN ŞAKUL Ayşe Arzu Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. Acta Medica Alanya 3, no.3 (2019): 306 - 310. 10.30565/medalanya.632455
MLA gunal mehmet yalcin,ÇANKAYA Seyda,TÖNÜK Şükrü Burak,ÖZDEMİR EKREM MUSA,SAYIN ŞAKUL Ayşe Arzu Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. Acta Medica Alanya, vol.3, no.3, 2019, ss.306 - 310. 10.30565/medalanya.632455
AMA gunal m,ÇANKAYA S,TÖNÜK Ş,ÖZDEMİR E,SAYIN ŞAKUL A Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. Acta Medica Alanya. 2019; 3(3): 306 - 310. 10.30565/medalanya.632455
Vancouver gunal m,ÇANKAYA S,TÖNÜK Ş,ÖZDEMİR E,SAYIN ŞAKUL A Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice. Acta Medica Alanya. 2019; 3(3): 306 - 310. 10.30565/medalanya.632455
IEEE gunal m,ÇANKAYA S,TÖNÜK Ş,ÖZDEMİR E,SAYIN ŞAKUL A "Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice." Acta Medica Alanya, 3, ss.306 - 310, 2019. 10.30565/medalanya.632455
ISNAD gunal, mehmet yalcin vd. "Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice". Acta Medica Alanya 3/3 (2019), 306-310. https://doi.org/10.30565/medalanya.632455
Sayfa Oluşturulma Tarihi
17-04-2024 17:7

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