An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes

KAZICI, Hilal ÇELİK

An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes

Hilal ÇELİK KAZICI (Van Yüzüncü Yıl Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü, Van, Türkiye)

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

2 0

Yıl: 2020 Cilt: 9 Sayı: 1 Sayfa Aralığı: 357 - 365 Metin Dili: İngilizce İndeks Tarihi: 20-11-2020

An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes

Öz:

In this study, the electrochemical behavior of propranolol was investigated on screen printed electrodes (SPCE)with reduced graphene oxide (rGO). Oxidation process, cyclic voltammetry (CV) and differential pulsevoltammetry (DPV) techniques were conducted by using measurements. The results showed that rGO increasedthe oxidation rate by increasing the peak current, and therefore oxidizing these drugs at appropriate potentials. Themodified SPCE exhibited excellent catalytic activity towards oxidation of the beta-blockers at an unusuallypositive potential in phosphate buffer solution (PBS). The linear concentration range and the detection limit of theproposed sensor for the detection of propranolol was 5- 50 µM and 2.61 µM, respectively

Anahtar Kelime:

İndirgenmiş Grafen Oksit Modifiye Yüzey Baskılı Karbon Elektrotlar Kullanılarak Beta-Bloker İlaçların Elektrokimyasal Davranışının Araştırılması

Öz:

Bu çalışmada, propranololün elektrokimyasal davranışı, indirgenmiş grafen oksit (rGO) ile modifiye edilmiş yüzey baskılı karbon elektrotlar (SPCE) ile incelenmiştir. Oksidasyon işlemi, döngüsel voltametri (CV) ve diferansiyel puls voltametri (DPV) teknikleri kullanılarak gerçekleştirilmiştir. Sonuçlar, rGO'nun oksidasyon pik akımını artırarak bu ilaçları uygun potansiyellerde oksitlediğini göstermiştir. Modifiye edilmiş SPCE, beta-blokerlerin, fosfat tampon çözeltisinde (PBS) alışılmadık derecede pozitif bir potansiyelde oksidasyonuna doğru mükemmel katalitik aktivite sergilemiştir. Propranololün tespiti için önerilen sensörün doğrusal konsantrasyon aralığı ve tespit limiti, sırasıyla, 50 µM ve 2.61 µM olarak elde edilmiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAZICI H (2020). An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. , 357 - 365.
Chicago	KAZICI Hilal ÇELİK An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. (2020): 357 - 365.
MLA	KAZICI Hilal ÇELİK An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. , 2020, ss.357 - 365.
AMA	KAZICI H An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. . 2020; 357 - 365.
Vancouver	KAZICI H An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. . 2020; 357 - 365.
IEEE	KAZICI H "An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes." , ss.357 - 365, 2020.
ISNAD	KAZICI, Hilal ÇELİK. "An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes". (2020), 357-365.

APA	KAZICI H (2020). An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 9(1), 357 - 365.
Chicago	KAZICI Hilal ÇELİK An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 9, no.1 (2020): 357 - 365.
MLA	KAZICI Hilal ÇELİK An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol.9, no.1, 2020, ss.357 - 365.
AMA	KAZICI H An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2020; 9(1): 357 - 365.
Vancouver	KAZICI H An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2020; 9(1): 357 - 365.
IEEE	KAZICI H "An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes." Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 9, ss.357 - 365, 2020.
ISNAD	KAZICI, Hilal ÇELİK. "An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes". Bitlis Eren Üniversitesi Fen Bilimleri Dergisi 9/1 (2020), 357-365.