Yıl: 2020 Cilt: 7 Sayı: 1 Sayfa Aralığı: 58 - 63 Metin Dili: İngilizce DOI: 10.4274/jus.galenos.2020.3123 İndeks Tarihi: 22-11-2020

Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections

Öz:
Objective: Vesicoureteral reflux (VUR) is considered the most important predisposing factor for urinary tract infection (UTI). Renal damage due toVUR, subsequently renal scarring and the possibility of reflux nephropathy warrant early detection of VUR. Our aim was to evaluate the value ofpositioned instillation of contrast (PIC) cystography in the detection of VUR in children with recurrent UTI and a normal voiding cystourethrography(VCUG).Materials and Methods: PIC cystography was performed in each child with the indication of recurrent UTI with a normal VCUG between June 2015and November 2017.Results: Thirty-four children (32 girls, 2 boys) aged 7 to 17 years (median, 10 years), were examined. Twenty (58.8%) patients had normal ultrasoundand 12 patients (35.3%) had bilateral scars detected using 99mTc-dimercaptosuccinic acid (DMSA). Thirty-one (91.2%) patients were shown tohave VUR on PIC cystography. Nine (29%) patients had no renal scar with positive PIC and 3 (12%) patients had scars with negative PIC. Scars weredetected in 13 (72.2%) patients with grade I-II VUR, and 4 (30.8%) with grade III-IV VUR had no scars on DMSA. There was no significant differencebetween the results of PIC and DMSA renal scan. Twenty-six patients (76.5%) with PIC-VUR underwent simultaneous endoscopic injections. Duringthe postoperative follow-up with an average of 12 months, 27 patients showed no evidence of febrile UTIs.Conclusion: Based on our results, PIC cystogram seems to be a good alternative to invasive voiding cystourethrogram in screening children for VUR
Anahtar Kelime:

Tekrarlayan İdrar yolu Enfeksiyonu olan Çocuklarda Pozisyonel Yerleştirilen Kontrast Sistografinin Değerlendirilmesi

Öz:
Amaç: Vezikoüreteral reflü (VUR) idrar yolu enfeksiyonu (İYE) için en önemli predispozan faktördür. VUR’ye bağlı böbrek hasarı, böbrekte skar oluşumu ve reflü nefropatisi olasılığı, VUR’nun tespiti için en önemli gerekçelerdir. Amacımız , voiding sistoüretrografi (VCUG) reflü tespit edilmemiş tekrarlayan idrar yolu enfeksiyonlu (İYE) çocuklarda VUR saptanmasında konumlu kontrast yerleştirme (PIC) sistografinin değerlendirilmesidir. Gereç ve Yöntem: Haziran 2015 - Kasım 2017 tarihleri arasında VCUG’de reflü tespit edilmemiş tekrarlayan İYE’li çocuklara PIC sistografi yapıldı. Bulgular: Otuz dört çocuk, yaşları 7-17 arasında değişen (yaşları ortanca, 10 yaş) 32’si kız olan çocuklar incelendi. Yirmi (%58,8) hastada normal US, 12 hastada (%35,3) 99m-Tc-dimerkaptosüksinik asit (DMSA) kullanılarak iki taraflı skar tespit edildi. Otuz bir (%91,2) hastanın PIC sistografisinde VUR olduğu görüldü. Dokuz (%29) hastada PIC pozitif, renal skar yoktu ve 3 (%12) hastada negatif PIC ile skar vardı. DMSA’da grade I-II VUR’li 13 (%72,2) hastada ve grade III-IV VUR’lu 4 hastada (%30,8) skar saptanmadı. PIC sistografide reflü ile DMSA’da skar arasında anlamlı ilişki bulunmadı. PIC-VUR’u olan 25 hastaya (%76,5) eş zamanlı endoskopik enjeksiyon yapıldı. Postoperatif dönemde ortalama 12 ay takipte olan 27 hastada ateşli İYE tekrarlamadı. Sonuç: Elde ettiğimiz sonuçlara göre, PIC sistogram VCUG’de reflü tespit edilmemiş tekrarlayan İYE’li çocuklarda VUR saptanmasında alternatif bir tanı aracı olarak kullanılması yararlı görülmektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Bell LE, Mattoo TK. Update on childhood urinary tract infection and vesicoureteral reflux. Semin Nephrol 2009;29:349-359.
  • 2. Lim R. Vesicoureteral reflux and urinary tract infection: evolving practices and current controversies in pediatric imaging. Am J Roentgenol 2009;192:1197-1208.
  • 3. Mahyar A, Ayazi P, Tarlan S, Moshiri A, Hamidfar M, Barikani A. When is the best time for voiding cystourethrogram in urinary tract infection of children? Acta Med Iran 2012;50:468-472.
  • 4. Belman AB. A perspective on vesicoureteral reflux. Urol Clin North Am 1995;22:139-150.
  • 5. Hellerstein S. Urinary tract infections. Old and new concepts. Pediatr Clin North Am 1995;42:1433-1457.
  • 6. Darge K, Riedmiller H. Current status of vesicoureteral reflux diagnosis. World J Urol 2004;22:88-95.
  • 7. Dalirani R, Mahyar A, Sharifian M, Mohkam M, Esfandiar N, Ghehsareh Ardestani A. The value of direct radionuclide cystography in the detection of vesicoureteral reflux in children with normal voiding cystourethrography. Pediatr Nephrol 2014;29:2341-2345.
  • 8. Lee RS, Diamond DA, Chow JS. Applying the ALARA concept to the evaluation of vesicoureteric reflux. Pediatr Radiol 2006;36:185-191.
  • 9. Doganis D, Siafas K, Mavrikou M, Issaris G, Martirosova A, Perperidis G, Konstantopoulos A, Sinaniotis K. Does early treatment of urinary tract infection prevent renal damage? Pediatrics 2007;120:922-928.
  • 10. Sükan A, Bayazit AK, Kibar M, Noyan A, Soyupak S, Yapar Z, Anarat A. Comparison of direct radionuclide cystography and voiding direct cystography in the detection of vesicoureteral reflux. Ann Nucl Med 2003;17:549-553.
  • 11. Rubenstein JN, Maizels M, Kim SC, Houston JT. The PIC cystogram: a novel approach to indentify ‘‘occult’’ vesicoureteral reflux in children with febrile urinary tract infections. J Urol 2003;169:2339-2343.
  • 12. Edmonson JD, Maizels M, Alpert SA. Kirsch AJ, Hanna MK, Weiser AC, Caione P, Kaplan WE, Cheng EY, Houston JT. Multi-instutitional experience with PIC cystography-incidence of occult vesicoureteral reflux in children with febrile urinary tract infections. Urology 2006;67:608-611.
  • 13. Hagerty J, Maizels M, Kirsch A. Liu D, Afshar K, Bukowski T, Caione P, Homsy Y, Meyer T, Kaplan W; PIC Cystography Group. Treatment of occult reflux lowers the incidence rate of pediatric febrile urinary tract infection. Urology 2008;72:72-76.
  • 14. Haberal HB, Çıtamak B, Altan M, Bozacı AC, Ceylan T, Doğan HS, Tekgül S. Positioning the Instillation of Contrast Cystography: Does It Provide Any Clinical Benefit? Urology 2018;112:164-168.
  • 15. Goldraich IH, Goldraich NP, Ramos OL. Classification of reflux nephropathy according to findings at DMSA renal scan. Eur J Paediatr 1983;140:212-218.
  • 16. Lebowitz RL, Olbing H, Parkkulainen KV, Smellie JM, Tamminen-Möbius TE. International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol 1985;15:105-109.
  • 17. Tareen BU, Bui D, McMahon DR, Nasrallah PF. Role of positional instillation of contrast cystography in the algorithm for evaluating children with confirmed pyelonephritis. Urology 2006;67:1055-1057.
  • 18. Navai N, Halperin W, Maizels M, Yerkes EB, Hagerty J, Kaplan WE. Demonstrating vesicoureteral reflux by positioning the instillation of contrast is a physiological test by manometry. J Urol 2008;179:203.
  • 19. Pinto KJ, Pugach J, Saalfield J. Lack of usefulness of positioned instillation of contrast cystogram after injection of dextranomer/hyaluronic acid. J Urol 2006;176:2654-2656.
  • 20. Palmer LS. The role of intraoperative cystography following the injection of dextranomer/hyaluronic acid copolymer. J Urol 2008;179:1118-1121.
  • 21. Berger C, Becker T, Koen M, Zeino M, Fitz F, Beheshti M, Wolf-Kohlmeier I, Haim S, Riccabona M. Positioning irrigation of contrast cystography for diagnosis of occult vesicoureteric reflux: association with technetium-99m dimercaptosuccinic acid scans. J Pediatr Urol 2013;9:846-850.
  • 22. Karadeniz-Cerit K, Thomas DT, Ergun R, Yıldız N, Alpay H, Inanir S, Dağlı ET, Tuğtepe H. Positional installation of contrast (PIC) and Redo-PIC cystography for diagnosis of occult vesicoureteral reflux. Turk J Pediatr 2018;60:180-187.
  • 23. Avlan D, Gündoğdu G, Taşkınlar H, Delibaş A, Naycı A. Relationships among vesicoureteric reflux, urinary tract infection and renal injury in children with non-neurogenic lower urinary tract dysfunction. J Pediatr Urol 2011;7:612-615.
APA Nalcacioglu H, Demirci D, Dursun I, BAYDİLLİ N, nalcacioglu v, Yel S, Baştuğ F, Gündüz Z, POYRAZOĞLU M, Dusunsel R (2020). Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. , 58 - 63. 10.4274/jus.galenos.2020.3123
Chicago Nalcacioglu Hulya,Demirci Deniz,Dursun Ismail,BAYDİLLİ NUMAN,nalcacioglu varol,Yel Sibel,Baştuğ Funda,Gündüz Zübeyde,POYRAZOĞLU M. Hakan,Dusunsel Ruhan Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. (2020): 58 - 63. 10.4274/jus.galenos.2020.3123
MLA Nalcacioglu Hulya,Demirci Deniz,Dursun Ismail,BAYDİLLİ NUMAN,nalcacioglu varol,Yel Sibel,Baştuğ Funda,Gündüz Zübeyde,POYRAZOĞLU M. Hakan,Dusunsel Ruhan Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. , 2020, ss.58 - 63. 10.4274/jus.galenos.2020.3123
AMA Nalcacioglu H,Demirci D,Dursun I,BAYDİLLİ N,nalcacioglu v,Yel S,Baştuğ F,Gündüz Z,POYRAZOĞLU M,Dusunsel R Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. . 2020; 58 - 63. 10.4274/jus.galenos.2020.3123
Vancouver Nalcacioglu H,Demirci D,Dursun I,BAYDİLLİ N,nalcacioglu v,Yel S,Baştuğ F,Gündüz Z,POYRAZOĞLU M,Dusunsel R Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. . 2020; 58 - 63. 10.4274/jus.galenos.2020.3123
IEEE Nalcacioglu H,Demirci D,Dursun I,BAYDİLLİ N,nalcacioglu v,Yel S,Baştuğ F,Gündüz Z,POYRAZOĞLU M,Dusunsel R "Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections." , ss.58 - 63, 2020. 10.4274/jus.galenos.2020.3123
ISNAD Nalcacioglu, Hulya vd. "Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections". (2020), 58-63. https://doi.org/10.4274/jus.galenos.2020.3123
APA Nalcacioglu H, Demirci D, Dursun I, BAYDİLLİ N, nalcacioglu v, Yel S, Baştuğ F, Gündüz Z, POYRAZOĞLU M, Dusunsel R (2020). Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. Journal of Urological Surgery, 7(1), 58 - 63. 10.4274/jus.galenos.2020.3123
Chicago Nalcacioglu Hulya,Demirci Deniz,Dursun Ismail,BAYDİLLİ NUMAN,nalcacioglu varol,Yel Sibel,Baştuğ Funda,Gündüz Zübeyde,POYRAZOĞLU M. Hakan,Dusunsel Ruhan Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. Journal of Urological Surgery 7, no.1 (2020): 58 - 63. 10.4274/jus.galenos.2020.3123
MLA Nalcacioglu Hulya,Demirci Deniz,Dursun Ismail,BAYDİLLİ NUMAN,nalcacioglu varol,Yel Sibel,Baştuğ Funda,Gündüz Zübeyde,POYRAZOĞLU M. Hakan,Dusunsel Ruhan Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. Journal of Urological Surgery, vol.7, no.1, 2020, ss.58 - 63. 10.4274/jus.galenos.2020.3123
AMA Nalcacioglu H,Demirci D,Dursun I,BAYDİLLİ N,nalcacioglu v,Yel S,Baştuğ F,Gündüz Z,POYRAZOĞLU M,Dusunsel R Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. Journal of Urological Surgery. 2020; 7(1): 58 - 63. 10.4274/jus.galenos.2020.3123
Vancouver Nalcacioglu H,Demirci D,Dursun I,BAYDİLLİ N,nalcacioglu v,Yel S,Baştuğ F,Gündüz Z,POYRAZOĞLU M,Dusunsel R Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections. Journal of Urological Surgery. 2020; 7(1): 58 - 63. 10.4274/jus.galenos.2020.3123
IEEE Nalcacioglu H,Demirci D,Dursun I,BAYDİLLİ N,nalcacioglu v,Yel S,Baştuğ F,Gündüz Z,POYRAZOĞLU M,Dusunsel R "Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections." Journal of Urological Surgery, 7, ss.58 - 63, 2020. 10.4274/jus.galenos.2020.3123
ISNAD Nalcacioglu, Hulya vd. "Assessment of Positioned Instillation of Contrast Cystography in Children with Recurrent Urinary Tract Infections". Journal of Urological Surgery 7/1 (2020), 58-63. https://doi.org/10.4274/jus.galenos.2020.3123