Selda BULCA
(Aydın Adnan Menderes Üniversitesi, Mühendislik Fakültesi, Gıda Mühendisliği Bölümü, Aydın, Türkiye)
Burcu GÜVENÇ
(Aydın Adnan Menderes Üniversitesi, Mühendislik Fakültesi, Gıda Mühendisliği Bölümü, Aydın, Türkiye)
Yıl: 2020Cilt: 8Sayı: 1ISSN: 2148-127X / 2148-127XSayfa Aralığı: 158 - 164Türkçe

33 0
Süt ve Süt Ürünlerinde Bulunan Biyoaktif Peptitler, Antimikrobiyal Özellikleri ve İnsan Sağlığı Üzerindeki Etkileri
Son yıllarda gıdaların besin değerinin yanı sıra fonksiyonel özellikleri de önem kazanmıştır. Biyoaktif peptitler, insan sağlığı üzerine olumlu etkilere sahip proteinlerin parçalanma ürünleri olarak tanımlanmıştır. İnek sütünde bulunan biyoaktif peptitler, süt proteinlerinin proteolitik enzimlerle hidrolizi sonucunda açığa çıkar. Biyoaktif peptitler, bağışıklık sistemini uyarıcı, mineral bağlayıcı, antimikrobiyal, antihipertansif, opioid, antioksidatif, antiülseratif, antitrombotik, antitümör ve apoptoz etki gibi değişik biyokimyasal ve fizyolojik özelliklere sahiptir. Bu çalışmada süt ve süt ürünlerinde bulunan biyoaktif peptitler, antimikrobiyal özellikleri ve insan sağlığı üzerindeki etkileri değerlendirilmiştir.
DergiDerlemeErişime Açık
  • Anonim. 2004. Türk Gıda Kodeksi Etiketleme Yönetmeliği, Fonksiyonel Gıdalarla ilgili Yasal Düzenlemeler, 5996 Yetki Kanunu
  • Barac M, Smiljanic M, Zilic S, Pesic M, Stanojevic S, Vasic M, Vucic T. 2016. Protein profiles and total antioxidant capacity of water soluble and insoluble protein fractions of white cow cheese at different stage of ripening, Mljekarstvo, 66(3): 187-197.
  • Beermann C, Hartung J. 2012. Physiological properties of milk ingredients released by fermentation. Food & Function, 4: 185-189
  • Bellamy WR, Yamauchi K, Wakabayashi H, Takase M, Shimamura S, Tomita M. 1994. Antifungal properties of lactoferricin, a peptide derived from the N-terminal region of bovine lactoferrin. Letters in Applied Microbiology, 18: 230–233
  • Beulens JWJ, Bindels JG, de Graaf C, Alles MS, Wouters-Wesseling W. 2004. Alpha lactalbumin combined with a regular diet increases plasma Trp-LNAA ratio. Physiology & Behavior, 81: 585–93.
  • Bhat ZF, Kumar S, Bhat HF. 2015. Antihypertensive Peptides of Animal Origin: A Review; Critical Reviews in Food Science and Nutrition, May 5.
  • Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. 2003. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. Journal of Biological Chemistry, 278: 10993–11001.
  • Chinen J, Finkelman F, Shearer WT. 2006. Advances in basic and clinical immunology. The Journal of Allergy and Clinical Immunology, 118: 489-95.
  • Clare DA, Swaisgood HE. 2000. Bioactive Milk Peptides: A Prospectus. Journal of Dairy Science, 83: 1187-1195.
  • Correa APF, Daroit DJ, Coelho J, Meira SM, Lopes FC, Segalin J, Risso PH, Brandelli A. 2011. Antioxidant, antihypertensive and antimicrobial properties of ovine milk caseinate hydrolyzed with a microbial protease. Journal of the Science of Food and Agriculture, 91(12): 2247-2254.
  • De Moreno A, de Leblanc, Perdigon G. 2005. Reduction of β-Glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model, Biocell, 29(1): 15–24
  • Denizli A, Yavuz H. 2011. Kan liflerinin biyokimyası, Tübitak Bilim ve Teknik dergisi, Nisan 2011: 64-67.
  • Ebringer L, Ferenčík M, Krajčovič J 2008. Beneficial Health Effects of Milk and Fermented Dairy Products. Folia Microbiologica, 53(5): 378-394.
  • El-Salam A, El-Shibiny S, and Buchheim W. 1996. Characteristics and potential uses of the casein macropeptide. International Dairy Journal, 6(4): 327– 341.
  • FitzGerald R. J. And Meisel H. 2003. Milk protein hydrolysates and bioactive peptides. In Advanced Dairy Chemistry- Vol 1: Proteins; Fox, P. F. and McSweeney, P. L. H., Ed.; Kluwer Academic/Plenum Publishers: New York, 675-698.
  • Fujita H, Yoshikawa M. 1999. A prodrug-type ACE inhibitory peptide derived from fish protein. Immunopharmacology, 44: 123-127.
  • Gill HS, Doull F, Rutherfurd KJ, Cross ML. 2000 Immunoregulatory Peptides in Bovine Milk. British Journal of Nutrition, 84: 111-117.
  • Gobbetti M, Minervini F, Rizzello CG. 2004. Angiotensin I converting-enzyme-inhibitory and antimicrobial bioactive peptides. International Journal of Dairy Technology, 57: 172-188.
  • Haque E, Chan R. 2006. Milk protein derived bioactive peptides. https://www.dairyscience.info/index.php/exploitation-of-anti-microbial-proteins/111-milk-protein-derived-bioactive-peptides.html. (Erişim 30 Aralık 2018)
  • Haque E, Chand R, Kapila S. 2009. Biofunctional Properties of Bioactive Peptides of Milk Origin. Food Reviews International, 25: 28-43.
  • Hartmann R, Meisel H. 2007. Food-derived peptides with biological activity: from research to food applications. Current Opinion in Biotechnology, 18: 163–169.
  • Inoue K, Gotou T, Kitajima H, Mizuno S, Nakazawa T, Yamamoto N. 2009. Release of antihypertensive peptides in miso paste during its fermentation, by the addition of casein. Journal of Bioscience and Bioengineering, 108: 111-115.
  • Kasai T, Honda T, Kiriyama S. 1992. Caseinophosphopeptides (CPP) in faeces of rats fed a casein diet. Bioscience, Biotechnology and Biochemistry, 56: 1150–1151.
  • Kelleher SL, Chatterton D, Nielsen K, Lonnerdal B. 2003. Glycomacropeptide and a-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. The American Journal of Clinical Nutrition, 77(5): 1261– 1268.
  • Kitts DD, Weiler K. 2003. Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Current Pharmaceutical Design 9: 1309-1323.
  • Knyazeva EL, Grishchenko VM, Fadeev RS, Akatov VS, Permyakov SE, Permyakov EA. 2008. Who is Mr. Hamlet Interaction of human α-lactalbumin with monomeric oleic acid. Biochemistry, 47: 13127–13137.
  • Korhonen H, Pihlanto-Leppälä A. 2006. Bioactive Peptides: Production and Functionality. International Dairy Journal, 16: 945-960.
  • Korhonen H. 2009. Milk-derived bioactive peptides: From science to applications. Journal of Functional Foods, 1: 177-187.
  • Lahov E, Regelson W. 1996. Antibacterial and immunostimulating casein-derived substances from milk: casecidin, isracidin peptides. Food and Chemical Toxicology, 34: 131–145.
  • Markus CR, Jonkman LM, Lammers JHC, Deutz NEP, MesserMH, Rigtering N. 2005. Evening intake of α-lactalbumin increases plasma tryptophan availability and improves morning alertness and brain measures of attention. The American Journal of Clinical Nutrition, 81: 1026–1033.
  • Marshall K 2004. Therapeutic applications of whey protein. Alternative Medicine Review, 9: 136-156.
  • Meisel H. 1998. Overview on Milk Protein-Derived Peptides. International Dairy Journal, 8: 363-373.
  • Meisel H. 2005. Biochemical properties of peptides encrypted in bovine milk proteins. Current Medicinal Chemistry, 12: 1905-1919.
  • Mishra VK, Mohammad G, Jha A. 2008. Immunomodulation and anticancer potentials of yogurt probiotic, EXCLI Journal 7: 177– 184
  • Nielsen MS, Martinussen T, Flambard B, Sørensen KI, Otte J 2009. Peptide Profiles and Angiotensin-I- Converting Enzyme Inhibitory Activity of Fermented Milk Products: Effect of Bacterial Strain, Fermentation pH, and Storage Time. International Dairy Journal, 19: 155-165.
  • Öztürk, HI, Akin N. 2010. Comparison of some functionalities of water soluble peptides derived from Turkish cow and goat milk Tulum cheeses during ripening. Food Sci. Technol, Campinas, 38(4): 674-682
  • Parth CM. 2004. Essentials of Pathophysiology: Concepts of Altered Health States. Philadelphia: Lippincott Williams & Wilkins, 20: 134-149.
  • Picard C, Fioramonti J, Francois A, Robinson T, Neant F, Matuchansky C 2005. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits, Alimentary Pharmacology & Therapeutics, 22: 495–512.
  • Pihlanto A, Virtanen T, Korhonen H. 2010. Angiotensine I converting enzyme (ACE) inhibitory activity and antihypertensive effect of fermented milk. International Dairy Journal, 20: 3-10.
  • Pihlanto A. 2006. Antioxidative peptides derived from milk proteins. International Dairy Journal, 16 (11): 1306-1314.
  • Pihlanto-Leppälä A, Rokka T, Korhonen H. 1998. Angiotensin I Converting Enzyme Inhibitory Peptides Derived from Bovine Milk Proteins. International Dairy Journal, 8: 325-331.
  • Pihlanto-Leppälä A. 2001. Bioactive peptides derived from bovine whey proteins: opioid and ACE-inhibitory peptide. Trends in Food Science and Technology, 11: 347–356.
  • Rizzello CG, Losito I, Gobbetti M, Carbonara T, Bari M, Zambonin P. 2005. Antibacterial activities of peptides from the water-soluble extracts of Italian cheese varieties. Journal of Dairy Science, 88(7): 2348-2360.
  • Rutherfurd-Markwick KJ, Moughan PJ. 2005. Bioactive peptides derived from food. Journal of AOAC International, 88(3), 955-966. PMid:16001873.
  • Schanbacher FL, Talhouk RS, Murray FA, Gherman LI, Willet LB 1998. Milk-borne bioactive peptides, International Dairy Journal, 8: 393–403.
  • Seppo L, Jauhiainen T, Poussa T, Korpela R. 2003. A fermented milk high in bioactive peptides has a blood pressure lowering effect in hypertensive subjects. The American Journal of Clinical Nutrition, 77: 326-330.
  • Shin K, Yamauchi K, Teraguchi S, Hayasawa H, Tomita M, Otsuka Y, Yamazaki S. 1998. Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic Escherichia coli 0157:H7. Letters in Appllied. Microbiology 6: 407–411
  • Silva SV, Malcata FX. 2005. Caseins as a Source of Bioactive Peptides. International Dairy Journal, 15: 1-15.
  • Smacchi E, Gobbetti M. 2000. Bioactive Peptides in Dairy Products; Synthesis and Interaction with Proteolytic Enzymes. Food Microbiology, 17: 129-41.
  • Solieri L, Rutella GS, Tagliazucchi D. 2015. Impact of non-starter lactobacilli on release of peptides with angiotensin-converting enzyme inhibitory and antioxidant activities during bovine milk fermentation, Food Microbiology, 51: 108-116.
  • Stan EI, Ekimovskii AP, Aleinik SI, Zhuravlev BV. 1988. Heterogeneity and physiological activity of bovine k-casein proteolysis products. Voprosy Pitaniia, 1: 39–43.
  • Svanborg C, Agerstam H, Aronson A, Bjerkvig R, Duringer C, Fischer W, Gustafsson L, Hallgren O, Leijonhuvud I, Linse S, Mossberg A, Nilsson H, Pettersson J, Svensson M. 2003. Hamlet kills tumor cells by an apoptosis-like mechanism cellular, molecular, and therapeutic aspects. Advances in Cancer Research, 88: 1–29.
  • Şanlıdere H, Öner Z. 2006. Süt Ürünlerinde Bulunan Biyoaktif Peptitler ve Fonksiyonları. Gıda, 31(6): 311-317.
  • Tidona F, Criscione, A, Guastella AM, Zuccaro A, Bordonaro S, Marletta D. 2009. Bioactive peptides in dairy products, Italian Journal of Animal Science, 8: 315–340
  • Tirelli, A., De Noni, I., Resmini, P. 1997. Bioactive Peptides in Milk Products. Italian Journal of Food Science, 9 (2): 91-98.
  • Tome D, Ledoux N 1998. Nutritional and Physiological Role of Milk Protein Components. Bulletin of IDF, 336: 11-16.
  • Tomita M, Bellamy WR, Takase M, Yamauchi K, Wakabayashi H, Kawase K. 1991. Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin. Journal of Dairy Science, 74: 4137–4142
  • Yang N, Strom MB, Mekonnen SM, Svendsen JS, Rekdal O 2004. The effects of shortening lactoferrin derived peptides against tumour cells, bacteria and normal human cells. Journal of Peptide Science, 10: 37–46.
  • Zhang M, Yang Jr F, Yang F, Chen J, Zheng CY, Liang Y. 2009. Cytotoxic aggregates of α-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. Chemico Biological Interactions, 180: 131–142
  • Zucht HD, Raida M, Adermann K, Magert HJ, Forssman WG. 1995. Casocidin-I: a casein-alpha s2 derived peptide exhibits antibacterial activity. FEBS Letters, 372: 185–188.

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.