Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus

yalcin, mehmet muhittin; Ozkan, Cigdem; ayvaz, goksun; Çakır, Nuri; Cerit, Ethem Turgay; Törüner, Füsun; karakoc, ayhan; YETKİN, İLHAN; KALAN SARI, IŞILAY; EROĞLU ALTINOVA, ALEV; AKTURK, MUJDE; Konca Degertekin, Ceyla

Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus

Işılay KALAN SARI, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Alev EROĞLU ALTINOVA, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Çiğdem ÖZKAN, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Müjde AKTÜRK, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Ceyla KONCA DEĞERTEKİN, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Ethem Turgay CERİT, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Mehmet Muhittin YALÇIN, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Füsun BALOŞ TÖRÜNER, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Ayhan KARAKOÇ, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

İlhan YETKİN, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Göksun AYVAZ, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Nuri ÇAKIR, (Gazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Hastalıkları Bölümü, Ankara, Türkiye)

Diğer Yazarlar

Turkish Journal of Endocrinology and Metabolism

1 0

Yıl: 2020 Cilt: 24 Sayı: 2 Sayfa Aralığı: 109 - 114 Metin Dili: İngilizce İndeks Tarihi: 23-11-2020

Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus

Öz:

Objective: Pregnant women with type 1 diabetes mellitus(T1DM) have increased risk of fetal, maternal, and perinatalcomplications. In this report, we aimed to evaluate the effectsof continuous subcutaneous insulin infusion (CSII) therapy onpregnancy outcomes, glycemic control, and acute complicationsin pregnant women with T1DM. Material and Methods: Weretrospectively analyzed the data of 15 women with T1DM whowere on CSII therapy during their pregnancy, and who were followed up at our clinic between 2008 and 2014. Acute complications, fetal/maternal, and perinatal complications, and glycemiccontrol were analyzed. Results: The mean age of the patientswas 28.2±3.6 years, and the mean duration of diabetes was8±5.4 years. We did not observe severe hypoglycemic episodesand diabetic ketoacidosis during their pregnancy. The meanHbA1c levels at 4-8 weeks of pregnancy decreased from7.4±1.3% to 6.3±0.7% at 34-38 weeks of pregnancy. The meanduration of pregnancy and neonatal birth weight were 37.1±1.2weeks and 3.537±794 g, respectively. There were no stillbirths,perinatal infant deaths, or congenital malformations noted.There were two preterm births due to preeclampsia, one ofwhom had a low birth weight (1.800 g). We recorded one macrosomic baby (4.730 g). Conclusion: We observed that glycemic control improved with CSII therapy during pregnancy. Wedid not detect severe hypoglycemia or diabetic ketoacidosis inour research. In pregnant women with T1DM who had inadequate glycemic control with multiple daily insulin injection therapy, CSII might be a safe and appropriate treatment regimen.

Anahtar Kelime:

Tip 1 Diabetes Mellitusu Olan Gebelerde Sürekli Subkütan İnsülin İnfüzyon Tedavisinin Akut Komplikasyonlar ve Gebelik Sonlanımı Üzerine Etkisi

Öz:

Amaç: Tip 1 diabetes mellituslu (T1DM) gebe kadınlarda fetal, maternal ve perinatal komplikasyon riski artmıştır. Bu raporda, T1DM'li gebelerde sürekli subkütan insülin infüzyonu [continuous subcutaneous insulin infusion (CSII)]nun gebelik sonuçları, glisemik kontrol ve akut komplikasyonlar üzerine etkilerini değerlendirmeyi amaçladık. Gereç ve Yöntemler: 2008-2014 yılları arasında kliniğimizde izlenen CSII tedavisi alan T1DM’li 15 kadının verileri retrospektif olarak incelendi. Akut komplikasyonlar, fetal/maternal ve perinatal komplikasyonlar ile glisemik kontrol analiz edildi. Bulgular: Hastaların ortalama yaşı 28,2±3,6 yıl, ortalama diyabet süresi ise 8±5,4 yıl idi. Gebelikleri sırasında şiddetli hipoglisemik atak ve diyabetik ketoasidoz izlenmedi. Gebeliğin 4-8. haftalarında ölçülen ortalama HbA1c, gebeliğin 34-38. haftalarında %7,4±1,3'ten %6,3±0,7'ye geriledi. Ortalama gebelik süresi ve yenidoğan doğum ağırlığı sırasıyla 37,1±1,2 hafta ve 3.537±794 g idi. Ölü doğum, perinatal bebek ölümü veya konjenital malformasyon görülmedi. Preeklampsi nedeni ile iki preterm doğum görüldü. Bu yenidoğanlardan biri düşük doğum ağırlığına (1.800 g) sahipti. Bir makrozomik bebek kaydedildi (4.730 g). Sonuç: Çalışmamızda gebelik sırasında CSII tedavisi ile glisemik kontrolde düzelme izlendi, şiddetli hipoglisemi veya diyabetik ketoasidoz saptanmadı. Günlük çoklu enjeksiyon (MDI) tedavisi ile glisemik kontrolü sağlanamayan T1DM'li gebe kadınlarda, CSII tedavisinin güvenli ve uygun bir tedavi rejimi olabileceği sonucuna vardık.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KALAN SARI I, EROĞLU ALTINOVA A, Ozkan C, AKTURK M, Konca Degertekin C, Cerit E, yalcin m, Törüner F, karakoc a, YETKİN İ, ayvaz g, Çakır N (2020). Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. , 109 - 114.
Chicago	KALAN SARI IŞILAY,EROĞLU ALTINOVA ALEV,Ozkan Cigdem,AKTURK MUJDE,Konca Degertekin Ceyla,Cerit Ethem Turgay,yalcin mehmet muhittin,Törüner Füsun,karakoc ayhan,YETKİN İLHAN,ayvaz goksun,Çakır Nuri Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. (2020): 109 - 114.
MLA	KALAN SARI IŞILAY,EROĞLU ALTINOVA ALEV,Ozkan Cigdem,AKTURK MUJDE,Konca Degertekin Ceyla,Cerit Ethem Turgay,yalcin mehmet muhittin,Törüner Füsun,karakoc ayhan,YETKİN İLHAN,ayvaz goksun,Çakır Nuri Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. , 2020, ss.109 - 114.
AMA	KALAN SARI I,EROĞLU ALTINOVA A,Ozkan C,AKTURK M,Konca Degertekin C,Cerit E,yalcin m,Törüner F,karakoc a,YETKİN İ,ayvaz g,Çakır N Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. . 2020; 109 - 114.
Vancouver	KALAN SARI I,EROĞLU ALTINOVA A,Ozkan C,AKTURK M,Konca Degertekin C,Cerit E,yalcin m,Törüner F,karakoc a,YETKİN İ,ayvaz g,Çakır N Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. . 2020; 109 - 114.
IEEE	KALAN SARI I,EROĞLU ALTINOVA A,Ozkan C,AKTURK M,Konca Degertekin C,Cerit E,yalcin m,Törüner F,karakoc a,YETKİN İ,ayvaz g,Çakır N "Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus." , ss.109 - 114, 2020.
ISNAD	KALAN SARI, IŞILAY vd. "Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus". (2020), 109-114.

APA	KALAN SARI I, EROĞLU ALTINOVA A, Ozkan C, AKTURK M, Konca Degertekin C, Cerit E, yalcin m, Törüner F, karakoc a, YETKİN İ, ayvaz g, Çakır N (2020). Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism, 24(2), 109 - 114.
Chicago	KALAN SARI IŞILAY,EROĞLU ALTINOVA ALEV,Ozkan Cigdem,AKTURK MUJDE,Konca Degertekin Ceyla,Cerit Ethem Turgay,yalcin mehmet muhittin,Törüner Füsun,karakoc ayhan,YETKİN İLHAN,ayvaz goksun,Çakır Nuri Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism 24, no.2 (2020): 109 - 114.
MLA	KALAN SARI IŞILAY,EROĞLU ALTINOVA ALEV,Ozkan Cigdem,AKTURK MUJDE,Konca Degertekin Ceyla,Cerit Ethem Turgay,yalcin mehmet muhittin,Törüner Füsun,karakoc ayhan,YETKİN İLHAN,ayvaz goksun,Çakır Nuri Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism, vol.24, no.2, 2020, ss.109 - 114.
AMA	KALAN SARI I,EROĞLU ALTINOVA A,Ozkan C,AKTURK M,Konca Degertekin C,Cerit E,yalcin m,Törüner F,karakoc a,YETKİN İ,ayvaz g,Çakır N Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism. 2020; 24(2): 109 - 114.
Vancouver	KALAN SARI I,EROĞLU ALTINOVA A,Ozkan C,AKTURK M,Konca Degertekin C,Cerit E,yalcin m,Törüner F,karakoc a,YETKİN İ,ayvaz g,Çakır N Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus. Turkish Journal of Endocrinology and Metabolism. 2020; 24(2): 109 - 114.
IEEE	KALAN SARI I,EROĞLU ALTINOVA A,Ozkan C,AKTURK M,Konca Degertekin C,Cerit E,yalcin m,Törüner F,karakoc a,YETKİN İ,ayvaz g,Çakır N "Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus." Turkish Journal of Endocrinology and Metabolism, 24, ss.109 - 114, 2020.
ISNAD	KALAN SARI, IŞILAY vd. "Acute Complications and Pregnancy Outcomes with Continuous Subcutaneous Insulin Infusion Therapy in Pregnant Women with Type 1 Diabetes Mellitus". Turkish Journal of Endocrinology and Metabolism 24/2 (2020), 109-114.