Yıl: 2020 Cilt: 35 Sayı: 2 Sayfa Aralığı: 175 - 178 Metin Dili: İngilizce DOI: 10.5222/MMJ.2020.96641 İndeks Tarihi: 25-11-2020

A Rare Case of Metformin Intoxication with Mortal Course

Öz:
Metformin-associated lactic acidosis is a rare side effect in metformin poisoning. There is conflicting data about mortality rates changing from 3% to 83%. We aimed to discuss a case thatdeveloped lactic acidosis and acute renal failure progressing to mortality due to metforminintoxication. A 33 year-old female patient was admitted to the emergency department, withnausea and vomiting after taking 30 tablets of 1000 mg metformin. In the 2nd hour of follow-up,patient was observed to develop lactic acidosis which did not recover despite the infusion replacement treatments and hemodialysis. Following the development of respiratory failure, undermechanical ventilation, the patient developed cardiac arrest at the 48th hour of her admission.In metformin intoxications, it should be remembered that acidosis deepens very quickly andcan progress with mortality despite optimal supportive therapy. More specific recommendations and further studies are required for the management and treatment of acute metforminassociated lactic acidosis.
Anahtar Kelime:

Mortal Seyreden Nadir Bir Metformin İntoksikasyonu Olgusu

Öz:
Metformin ile ilişkili laktik asidoz, metformin zehirlenmesinde nadir görülen bir yan etkidir. Mortalite oranı hakkında %3’ten %83’e değişen çelişkili veriler mevcuttur. Bu çalışmada metformin zehirlenmesine bağlı laktik asidoz ve akut böbrek yetmezliği gelişen ve mortalite ile sonuçlanan bir olguyu tartışmayı amaçladık. 33 yaşında kadın hasta, 30 adet 1000 mg metformin tablet içtikten sonra acil servise bulantı ve kusma ile başvurdu. Takibinin 2. saatinde laktik asidoz geliştiği gözlendi, infüzyon replasman tedavilerine ve hemodiyalize rağmen metabolik asidozun derinleştiği görüldü. Solunum yetmezliği gelişen ve mekanik ventilasyon desteği verilen hastada, başvurusunun 48. saatinde kardiyak arrest gelişti. Metformin zehirlenmesine bağlı gelişen asidozun çok hızlı derinleştiği ve optimal destekleyici tedaviye rağmen mortaliteye ilerleyebileceği unutulmamalıdır. Akut metformin ilişkili laktik asidozun yönetimi ve tedavisinde daha spesifik önerilere ve daha ileri çalışmalara ihtiyaç vardır
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA Osoydan Satici M, Algın A, Aksel G, Eroğlu S (2020). A Rare Case of Metformin Intoxication with Mortal Course. , 175 - 178. 10.5222/MMJ.2020.96641
Chicago Osoydan Satici Merve,Algın Abdullah,Aksel Gökhan,Eroğlu Serkan Emre A Rare Case of Metformin Intoxication with Mortal Course. (2020): 175 - 178. 10.5222/MMJ.2020.96641
MLA Osoydan Satici Merve,Algın Abdullah,Aksel Gökhan,Eroğlu Serkan Emre A Rare Case of Metformin Intoxication with Mortal Course. , 2020, ss.175 - 178. 10.5222/MMJ.2020.96641
AMA Osoydan Satici M,Algın A,Aksel G,Eroğlu S A Rare Case of Metformin Intoxication with Mortal Course. . 2020; 175 - 178. 10.5222/MMJ.2020.96641
Vancouver Osoydan Satici M,Algın A,Aksel G,Eroğlu S A Rare Case of Metformin Intoxication with Mortal Course. . 2020; 175 - 178. 10.5222/MMJ.2020.96641
IEEE Osoydan Satici M,Algın A,Aksel G,Eroğlu S "A Rare Case of Metformin Intoxication with Mortal Course." , ss.175 - 178, 2020. 10.5222/MMJ.2020.96641
ISNAD Osoydan Satici, Merve vd. "A Rare Case of Metformin Intoxication with Mortal Course". (2020), 175-178. https://doi.org/10.5222/MMJ.2020.96641
APA Osoydan Satici M, Algın A, Aksel G, Eroğlu S (2020). A Rare Case of Metformin Intoxication with Mortal Course. Medeniyet Medical Journal, 35(2), 175 - 178. 10.5222/MMJ.2020.96641
Chicago Osoydan Satici Merve,Algın Abdullah,Aksel Gökhan,Eroğlu Serkan Emre A Rare Case of Metformin Intoxication with Mortal Course. Medeniyet Medical Journal 35, no.2 (2020): 175 - 178. 10.5222/MMJ.2020.96641
MLA Osoydan Satici Merve,Algın Abdullah,Aksel Gökhan,Eroğlu Serkan Emre A Rare Case of Metformin Intoxication with Mortal Course. Medeniyet Medical Journal, vol.35, no.2, 2020, ss.175 - 178. 10.5222/MMJ.2020.96641
AMA Osoydan Satici M,Algın A,Aksel G,Eroğlu S A Rare Case of Metformin Intoxication with Mortal Course. Medeniyet Medical Journal. 2020; 35(2): 175 - 178. 10.5222/MMJ.2020.96641
Vancouver Osoydan Satici M,Algın A,Aksel G,Eroğlu S A Rare Case of Metformin Intoxication with Mortal Course. Medeniyet Medical Journal. 2020; 35(2): 175 - 178. 10.5222/MMJ.2020.96641
IEEE Osoydan Satici M,Algın A,Aksel G,Eroğlu S "A Rare Case of Metformin Intoxication with Mortal Course." Medeniyet Medical Journal, 35, ss.175 - 178, 2020. 10.5222/MMJ.2020.96641
ISNAD Osoydan Satici, Merve vd. "A Rare Case of Metformin Intoxication with Mortal Course". Medeniyet Medical Journal 35/2 (2020), 175-178. https://doi.org/10.5222/MMJ.2020.96641