Yıl: 2020 Cilt: 24 Sayı: 2 Sayfa Aralığı: 138 - 143 Metin Dili: İngilizce İndeks Tarihi: 24-11-2020

Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism

Öz:
Objective: Several lines of evidence suggest that the symptomsof hypothyroidism, including psychological symptoms and metabolic effects, persist in a significant percentage of patientstreated with levothyroxine (L-T4). A hypothesis to explain thisphenomenon is that the triiodothyronine (L-T3) serum levelsmay not be completely normalized. This study aimed to compare the level of serum free T3 (FT3) in patients who arebiochemically euthyroid after L-T4 monotherapy with differentunderlying causes of hypothyroidism. Material and Methods:This cross-sectional study was conducted on patients withhypothyroidism who received L-T4 monotherapy and were biochemically euthyroid. The serum levels of thyroid-stimulatinghormone (TSH), free T4 (FT4), FT3, and FT3/FT4 ratio weremeasured in these patients. Patients were divided into threegroups based on the cause of hypothyroidism (radioiodine therapy, thyroidectomy and Hashimoto), and the results of biochemical tests of the thyroid were compared in three groups.Results: Of the 78 patients studied, 12 (15.4%) cases weremale, and 66 (84.6%) cases were female. Among the variablesstudied, only the mean value of FT3 was significantly differentin the three groups (p=0.006), where the highest mean valuewas seen in the Hashimoto group, and the lowest mean valuewas seen in the radioiodine therapy group. Conclusion: The results of this study showed that although hypothyroidism patients can be optimally treated with L-T4 alone, in many of thesepatients, the level of FT3 will not be in therapeutic range, andthe mean serum FT3 levels in these patients could be related totheir hypothyroidism causes.
Anahtar Kelime:

Farklı Hipotiroidizm Nedenleri Dolayısıyla Levotiroksin ile Tedavi Edilen Hastalarda Triiyodotironin Seviyesinin Karşılaştırılması

Öz:
Amaç: Çeşitli kanıtlar, levotiroksin (L-T4) ile tedavi edilen hastaların önemli bir kısmında, psikolojik semptomlar ve metabolik etkiler dâhil olmak üzere hipotiroidizm semptomlarının sebat ettiğini göstermektedir. Bu fenomeni açıklamak üzere öne sürülen bir hipotez, triiyodotironin (L-T3) serum seviyelerinin tamamen normalleştirilememesidir. Bu çalışmada, altta yatan hipotiroidizm nedenleri farklı olup L-T4 monoterapisi sonrası biyokimyasal olarak ötiroid olan hastalarda serum serbest T3 (sT3) düzeylerini karşılaştırmak amaçlanmıştır. Gereç ve Yöntemler: Kesitsel tipteki bu çalışma, L-T4 monoterapisi alan ve biyokimyasal olarak ötiroid olan hipotiroidili hastalarda gerçekleştirildi. Bu hastalarda tiroid uyarıcı hormon (TSH), serbest T4 (sT4), sT3 serum düzeyleri ve sT3/sT4 oranı ölçüldü. Hastalar, hipotiroidizmin nedenine göre üç gruba ayrıldı (radyoiyot tedavisi, tiroidektomi ve Hashimoto) ve tiroid biyokimyasal testlerinin sonuçları bu üç grupta karşılaştırıldı. Bulgular: Çalışmaya alınan 78 hastanın 12 (%15,4)'si erkek, 66 (%84,6)'sı kadındı. İncelenen değişkenler içinde, sadece ortalama sT3 değeri üç grup arasında anlamlı olarak farklıydı (p=0,006) ve en yüksek ortalama değer Hashimoto grubunda, en düşük ortalama değer ise radyoiyot tedavisi grubunda görüldü. Sonuç: Bu çalışmanın sonuçları, hipotiroidizm hastaları tek başına L-T4 ile optimal şekilde tedavi edilebilmesine rağmen, bu hastaların çoğunda sT3 seviyesinin terapötik aralıkta olmayacağını göstermiştir ve bu hastalardaki ortalama serum sT3 düzeyleri hipotiroidizmin nedeni ile ilişkili olabilir.
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APA Hemmatabadi M, Azizimanesh S, esfahanian f, mohajeri-tehrani m, Shirzad N (2020). Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. , 138 - 143.
Chicago Hemmatabadi Mahboobeh,Azizimanesh Samaneh,esfahanian fatemeh,mohajeri-tehrani mohammad reza,Shirzad Nooshin Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. (2020): 138 - 143.
MLA Hemmatabadi Mahboobeh,Azizimanesh Samaneh,esfahanian fatemeh,mohajeri-tehrani mohammad reza,Shirzad Nooshin Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. , 2020, ss.138 - 143.
AMA Hemmatabadi M,Azizimanesh S,esfahanian f,mohajeri-tehrani m,Shirzad N Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. . 2020; 138 - 143.
Vancouver Hemmatabadi M,Azizimanesh S,esfahanian f,mohajeri-tehrani m,Shirzad N Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. . 2020; 138 - 143.
IEEE Hemmatabadi M,Azizimanesh S,esfahanian f,mohajeri-tehrani m,Shirzad N "Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism." , ss.138 - 143, 2020.
ISNAD Hemmatabadi, Mahboobeh vd. "Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism". (2020), 138-143.
APA Hemmatabadi M, Azizimanesh S, esfahanian f, mohajeri-tehrani m, Shirzad N (2020). Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. Turkish Journal of Endocrinology and Metabolism, 24(2), 138 - 143.
Chicago Hemmatabadi Mahboobeh,Azizimanesh Samaneh,esfahanian fatemeh,mohajeri-tehrani mohammad reza,Shirzad Nooshin Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. Turkish Journal of Endocrinology and Metabolism 24, no.2 (2020): 138 - 143.
MLA Hemmatabadi Mahboobeh,Azizimanesh Samaneh,esfahanian fatemeh,mohajeri-tehrani mohammad reza,Shirzad Nooshin Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. Turkish Journal of Endocrinology and Metabolism, vol.24, no.2, 2020, ss.138 - 143.
AMA Hemmatabadi M,Azizimanesh S,esfahanian f,mohajeri-tehrani m,Shirzad N Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. Turkish Journal of Endocrinology and Metabolism. 2020; 24(2): 138 - 143.
Vancouver Hemmatabadi M,Azizimanesh S,esfahanian f,mohajeri-tehrani m,Shirzad N Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism. Turkish Journal of Endocrinology and Metabolism. 2020; 24(2): 138 - 143.
IEEE Hemmatabadi M,Azizimanesh S,esfahanian f,mohajeri-tehrani m,Shirzad N "Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism." Turkish Journal of Endocrinology and Metabolism, 24, ss.138 - 143, 2020.
ISNAD Hemmatabadi, Mahboobeh vd. "Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism". Turkish Journal of Endocrinology and Metabolism 24/2 (2020), 138-143.