Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

göksever çelik, hale; Celik, Engin; yetkin yildirim, gonca

Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

Hale GOKSEVER CELIK, (Sağlık Bilimleri Üniversitesi İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniği, İstanbul Türkiye)

Engin CELIK, (İstanbul Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul Türkiye)

Gonca Yetkin YILDIRIM (Sağlık Bilimleri Üniversitesi İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniği, İstanbul Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

8 0

Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 83 - 0 Metin Dili: İngilizce İndeks Tarihi: 24-11-2020

Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?

Öz:

OBJECTIVE: Digital cervical evaluation has been used to determine the likelihood of vaginal delivery which is considered by many women to be non-tolerable. Recently, alternative approaches such as transperineal ultrasound, fetal fibronectin test in cervicovaginal secretions have been investigating for the prediction of the delivery route. We aimed to study whether the usefulness of qualitative fetal fibronectin test in cervicovaginal secretions for the prediction of vaginal delivery in pregnant women at postterm induced with dinoprostone. STUDY DESIGN: A total of 32 nulliparous pregnant women at postterm were enrolled in this prospective observational study. Fetal fibronectin test was applied to all participated women before the induction with dinoprostone and transvaginal ultrasonography was performed to measure cervical length. RESULTS: The women having positive fetal fibronectin test result gave birth through vaginal route, except one case. Although there is no statistically significant difference, the shorter cervical length was associated with vaginal delivery in our population. CONCLUSION: Fetal fibronectin test has a predictive value for delivery route in nulliparous women at postterm. Fetal fibronectin test may be used as a “rule out” test because the rate of fetal fibronectin positivity was found to be higher in patients who gave birth via vaginal route. As also shown in our study, although there is no statistically significant difference, the pregnant women with shorter cervical length might have a high possibility to achieve vaginal delivery.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Eggebo TM, Wilhelm-Benartzi C, Hassan WA, Usman S, Salvesen KA, Lees CC. A model to predict vaginal delivery in nulliparous women based on maternal characteristics and intrapartum ultrasound. Am J Obstet Gynecol. 2015;213(3):362.e1-6.
2. Bruijn MM, Vis JY, Wilms FF, Oudijk MA, Kwee A, Porath MM, et al. Comparison of the Actim Partus test and the fetal fibronectin test in the prediction of spontaneous preterm birth in symptomatic women undergoing cervical length measurement. Eur J Obstet Gynecol Reprod Biol. 2016;206:220-4.
3. Magro-Malosso E, Seravalli V, Cozzolino M, Spitaleri M, Susini T, Di Tommaso M. Prediction of preterm delivery by fetal fibronectin in symptomatic and asymptomatic women with cervical length ≤20 mm. J Matern Fetal Neonatal Med. 2017;30(3):294-7.
4. DeFranco EA, Lewis DF, Odibo AO. Improving the screening accuracy for preterm labor: is the combination of fetal fibronectin and cervical length in symptomatic patients a useful predictor of preterm birth? A systematic review. Am J Obstet Gynecol. 2013;208(3):233.e1-6.
5. Zhou MX, Zhou J, Bao Y, Chen YQ, Cai C. Evaluation of the ability of cervical length and fetal fibronectin measurement to predict preterm delivery in asymptomatic women with risk factors. J Matern Fetal Neonatal Med. 2015;28(2):153-7.
6. Bruijn M, Vis JY, Wilms FF, Oudijk MA, Kwee A, Porath MM, et al. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women. BJOG. 2016;123(12):1965-71.
7. Shaikh F, Shaikh S, Shaikh N. Outcome of primigravida with high head at term. J Pak Med Assoc.2014;64(9): 1012-4.
8. Bahadori F, Ayatollahi H, Naghavi-Behzad M, Khalkhali H, Naseri Z. Predicting factors on cervical ripening and response to induction in women pregnant over 37 weeks. Med Ultrason. 2013; 15(3):191-8.
9. Meijer-Hoogeveen M, Roos C, Arabin B, Stoutenbeek P, Visser GH. Transvaginal ultrasound measurement of cervical length in the supine and upright positions versus Bishop score in predicting successful induction of labor at term. Ultrasound Obstet Gynecol. 2009; 33(2):213-20.
10. Esplin MS, Elovitz MA, Iams JD, Parker CB, Wapner RJ, Grobman WA, et al. Predictive accuracy of serial transvaginal cervical lengths and quantitative vaginal fetal fibronectin levels for spontaneous preterm birth among nulliparous women. JAMA. 2017;317(10):1047-56.
11. Dudley D. Serial transvaginal cervical length measurements and quantitative vaginal fetal fibronectin concentrations did not predict spontaneous preterm birth in low-risk nulliparous women. Evid Based Med. 2017;22(5):188.
12. Melchor JC, Navas H, Marcos M, Iza A, De Diego M, Rando D, et al. Predictive performance of PAMG-1 vs fFN test for risk of spontaneous preterm birth in symptomatic women attending an emergency obstetric unit: retrospective cohort study Ultrasound Obstet Gynecol. 2018; 51(5):644-9.
13. van Baaren GJ, Vis JY, Wilms FF, Oudijk MA, Kwee A, Porath MM, et al. Cost-effectiveness of diagnostic testing strategies including cervical length measurement and fibronectin testing in women with symptoms of preterm labor. Ultrasound Obstet Gynecol. 2018;51(5):596-603.
14. Tripathi R, Tyagi S, Mala YM, Singh N, Pandey NB, Yadav P. Comparison of rapid bedside tests for phosphorylated insulin-like growth factor-binding protein 1 and fetal fibronectin to predict preterm birth. Int J Gynaecol Obstet. 2016;135(1):47-50.
15. Hezelgrave NL, Kuhrt K, Cottam K, Seed PT, Tribe RM, Shennan AH. The effect of blood staining on cervicovaginal quantitative fetal fibronectin concentration and prediction of spontaneous preterm birth. Eur J Obstet Gynecol Reprod Biol. 2017;208:103-8.
16. Hezelgrave NL, Abbott DS, Radford SK, Seed PT, Girling JC, Filmer J, et al. Quantitative fetal Fibronectin at 18 weeks of gestation to predict preterm birth in asymptomatic high-risk women. Obstet Gynecol. 2016;127(2): 255-63.
17. Centra M, Coata G, Picchiassi E, Alfonsi L, Meniconi S, Bini V, et al. Evaluation of quantitative fFn test in predicting the risk of preterm birth. J Perinat Med. 2017;45(1):91-8.
18. Bruijn MM, Kamphuis EI, Hoesli IM, Martinez de Tejada B, Loccufier AR, Kühnert M, et al. The predictive value of quantitative fibronectin testing in combination with cervical length measurement in symptomatic women. Am J Obstet Gynecol. 2016;215(6):793.e1-793.e8.
19. Bruijn MM, Hermans FJ, Vis JY, Martinez de Tejada B, Loccufier AR, Kühnert M, et al. Which factors contribute to false-positive, false-negative, and invalid results in fetal fibronectin testing in women with symptoms of preterm labor? Am J Perinatol. 2017;34(3):234-9.
20. Tanır HM, Sener KT, Yildiz Z. Value of Pre-Induction Cervical Fetal Fibronectin (FFN) Assessment as A Predictor of Succesful Vaginal Birth in Nulliparas Undergoing Labor Induction. Gynecol Obstet Reprod Med. 2008;14(3):150-3.

APA	göksever çelik h, Celik E, yetkin yildirim g (2020). Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. , 83 - 0.
Chicago	göksever çelik hale,Celik Engin,yetkin yildirim gonca Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. (2020): 83 - 0.
MLA	göksever çelik hale,Celik Engin,yetkin yildirim gonca Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. , 2020, ss.83 - 0.
AMA	göksever çelik h,Celik E,yetkin yildirim g Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. . 2020; 83 - 0.
Vancouver	göksever çelik h,Celik E,yetkin yildirim g Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. . 2020; 83 - 0.
IEEE	göksever çelik h,Celik E,yetkin yildirim g "Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?." , ss.83 - 0, 2020.
ISNAD	göksever çelik, hale vd. "Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?". (2020), 83-0.

APA	göksever çelik h, Celik E, yetkin yildirim g (2020). Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. GORM:Gynecology Obstetrics & Reproductive Medicine, 26(2), 83 - 0.
Chicago	göksever çelik hale,Celik Engin,yetkin yildirim gonca Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. GORM:Gynecology Obstetrics & Reproductive Medicine 26, no.2 (2020): 83 - 0.
MLA	göksever çelik hale,Celik Engin,yetkin yildirim gonca Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.26, no.2, 2020, ss.83 - 0.
AMA	göksever çelik h,Celik E,yetkin yildirim g Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(2): 83 - 0.
Vancouver	göksever çelik h,Celik E,yetkin yildirim g Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(2): 83 - 0.
IEEE	göksever çelik h,Celik E,yetkin yildirim g "Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?." GORM:Gynecology Obstetrics & Reproductive Medicine, 26, ss.83 - 0, 2020.
ISNAD	göksever çelik, hale vd. "Does Fetal Fibronectin Predict the Delivery Route in Nulliparous Women at Postterm Induced by Dinoprostone?". GORM:Gynecology Obstetrics & Reproductive Medicine 26/2 (2020), 83-0.