Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?

Karlı, Pervin; ozdemir, ayse zehra

Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?

Ayşe Zehra ÖZDEMİR, (Ondokuz Mayıs Üniversitesi Tıp Fakültesi Tüp Bebek Merkezi Anabilim Dalı, Samsun, Türkiye)

Pervin KARLI (Amasya Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Amasya, Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

1 0

Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 110 - 115 Metin Dili: İngilizce İndeks Tarihi: 24-11-2020

Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?

Öz:

OBJECTIVE: Nowadays, fresh embryo transfers and frozen embryo transfers are frequently employed in the treatment of in vitro fertilization. This study aims to compare the pregnancy outcomes in patients who underwent fresh embryo transfers and frozen embryo transfers. STUDY DESIGN:All patients who underwent fresh embryo transfers and frozen embryo transfers at the in vitro fertilization center, Ondokuz Mayis University between 2010 and 2017 were screened retrospectively and the pregnancy results were evaluated at one-year follow-up. The study included a total of 912 transfers, 679 of which were fresh embryo transfers and 233 were fresh embryo transfers, in 756 patients. Comparisons were made in terms of biochemical pregnancy, clinical pregnancy rate, ongoing pregnancy, and live birth rate. RESULTS: Ectopic pregnancy, biochemical pregnancy, and abortus in fresh embryo transfers were found to be significantly more than that in frozen embryo transfers (p=0.001). However, no statistically significant difference in terms of clinical or ongoing pregnancy rate or live birth rate was observed. Birth weight was significantly lower in fresh embryo transfers than in frozen embryo transfers (p=0.001, p= 0.031). Multiple pregnancies preeclampsia, preterm labor, and placental abruption did not show a statistically significant difference in fresh embryo transfers and frozen embryo transfers. Yet, gestational diabetes was significantly more in frozen embryo transfers (p=0.011). CONCLUSIONS:Early pregnancy complications in fresh embryo transfers are higher than that in frozen embryo transfers. In terms of neonatal results, higher birth weight and gestational diabetes are more prevalent in frozen embryo transfers. In this study, it has been shown that fresh embryo transfers are more often associated with negative pregnancy outcomes. frozen embryo transfers can be better for pregnancy results.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Sperof L, Fritz MA. Assisted reproductive technologies. In: Mach A Fritz and Leon Speroff, editors. 8th Ed. Clinical gynecologic endocrinology and infertility. Philadelphia: Lippincott Williams & Wilkins; 2011. p. 1215-1270.
2. Grady R, Alavi N, Vale R, Khandwala M, McDonald SD. Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis. Fertil Steril. 2012;97(2):324-31.
3. Pinborg A, Loft A, Aaris Henningsen AK, Rasmussen S, Andersen AN. Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006. Fertil Steril. 2010;94(4):1320-7.
4. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and metaanalysis. Fertil Steril. 2012;98(2):368-77.
5. Wennerholm UB, Henningsen AK, Romundstad LB, Bergh C, Pinborg A, Skjaerven Ret al. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Hum Reprod. 2013;28(9):2545-53.
6. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96(2):344-8.
7. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders. Fertil Steril 2011;96(2):516-8.
8. Giorgetti C, Vanden Meerschaut F, De Roo C, Saunier O, Quarello E, Hairion D, et al. Multivariate analysis identifies the estradiol level at ovulation triggering as an independent predictor of the first trimester pregnancy-associated plasma protein-A level in IVF/ICSI pregnancies. Hum Reprod 2013;28(10):2636-42.
9. Pereira N, Reichman DE, Goldschlag DE, Lekovich JP, Rosenwaks Z. Impact of elevated peak serum estradiol levels during controlled ovarian hyperstimulation on the birth weight of term singletons from fresh IVF-ET cycles. J Assist Reprod Genet. 2015;32(4):527-32.
10. Solé M, Santaló J, Boada M, Clua E, Rodríguez I, Martínez F, et al. How does vitrification affect oocyte viability in oocyte donation cycles? A prospective study to compare outcomes achieved with fresh versus vitrified sibling oocytes. Hum Reprod. 2013;28(8):2087-92.
11. Cobo A, Kuwayama M, Pérez S, Ruiz A, Pellicer A, Remohí J. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method. Fertil Steril. 2008;89(6):1657-64.
12. Vidal M, Vellvé K, González-Comadran M, Robles A, Prat M, Torné M, et al. Perinatal outcomes in children born after fresh or frozen embryo transfer: a Catalan cohort study based on 14,262 newborns. Fertil Steril. 2017;107(4):940-7.
13. Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, et al. Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med. 2016;375(6):523-33.
14. Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, et al. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial. Fertil Steril. 2017;107(3):723-30.
15. Ferraretti AP, Gianaroli L, Magli C, Fortini D, Selman HA, Feliciani E. Elective cryopreservation of all pronucleate embryos in women at risk of ovarian hyperstimulation syndrome: efficiency and safety. Hum Reprod. 1999;14(6):1457-60.
16. Yang S, Pang T, Li R, Yang R, Zhen X, Chen X, et al. The individualized choice of embryo transfer timing for patients with elevated serum progesterone level on the HCG day in IVF/ICSI cycles: a prospective randomized clinical study. Gynecol Endocrinol. 2015;31(5):355-8.
17. Aflatoonian A, Mansoori Moghaddam F, Mashayekhy M, Mohamadian F. Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles. J Assist Reprod Genet. 2010;27(12):695700.
18. Aytoz A, Van den Abbeel E, Bonduelle M, Camus M, Joris H, Van Steirteghem A, et al. Obstetric outcome of pregnancies after the transfer of cryopreserved and fresh embryos obtained by conventional in-vitro fertilization and intracytoplasmic sperm injection. Hum Reprod. 1999; 14(10):2619-24.
19. Van Steirteghem AC, Van der Elst J, Van den Abbeel E, Joris H, Camus M, Devroey P. Cryopreservation of supernumerary multicellular human embryos obtained after intracytoplasmic sperm injection. Fertil Steril. 1994;62(4): 775-80.
20. Ishihara O, Kuwahara A, Saitoh H. Frozen-thawed blastocyst transfer reduces ectopic pregnancy risk: an analysis of single embryo transfer cycles in Japan. Fertil Steril. 2011;95(6):1966-9.
21. Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C. Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy. Fertil Steril. 2012;98(6):1490-4.
22. Jee BC, Suh CS, Kim SH. Ectopic pregnancy rates after frozen versus fresh embryo transfer: a meta-analysis. Gynecol Obstet Invest. 2009;68(1):53-7.
23. Maheshwari A, Raja EA, Bhattacharya S. Obstetric and perinatal outcomes after either fresh or thawed frozen embryo transfer: an analysis of 112,432 singleton pregnancies recorded in the Human Fertilisation and Embryology Authority anonymized dataset. Fertil Steril. 2016;106(7): 1703-8.
24. Pinborg A, Henningsen AA, Loft A, Malchau SS, Forman J, Andersen AN. Large baby syndrome in singletons born after frozen embryo transfer (FET): is it due to maternal factors or the cryotechnique? Hum Reprod. 2014;29(3): 618-27.
25. Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, Adamson GD. Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril. 2014;101(1):128-33.
26. Kato O, Kawasaki N, Bodri D, Kuroda T, Kawachiya S, Kato K, et al. Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2012;161(1):46-50.

APA	ozdemir a, Karlı P (2020). Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. , 110 - 115.
Chicago	ozdemir ayse zehra,Karlı Pervin Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. (2020): 110 - 115.
MLA	ozdemir ayse zehra,Karlı Pervin Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. , 2020, ss.110 - 115.
AMA	ozdemir a,Karlı P Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. . 2020; 110 - 115.
Vancouver	ozdemir a,Karlı P Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. . 2020; 110 - 115.
IEEE	ozdemir a,Karlı P "Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?." , ss.110 - 115, 2020.
ISNAD	ozdemir, ayse zehra - Karlı, Pervin. "Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?". (2020), 110-115.

APA	ozdemir a, Karlı P (2020). Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. GORM:Gynecology Obstetrics & Reproductive Medicine, 26(2), 110 - 115.
Chicago	ozdemir ayse zehra,Karlı Pervin Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. GORM:Gynecology Obstetrics & Reproductive Medicine 26, no.2 (2020): 110 - 115.
MLA	ozdemir ayse zehra,Karlı Pervin Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.26, no.2, 2020, ss.110 - 115.
AMA	ozdemir a,Karlı P Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(2): 110 - 115.
Vancouver	ozdemir a,Karlı P Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(2): 110 - 115.
IEEE	ozdemir a,Karlı P "Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?." GORM:Gynecology Obstetrics & Reproductive Medicine, 26, ss.110 - 115, 2020.
ISNAD	ozdemir, ayse zehra - Karlı, Pervin. "Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?". GORM:Gynecology Obstetrics & Reproductive Medicine 26/2 (2020), 110-115.