In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus

YILMAZ, İbrahim; özbek, hanefi; Kaya, Yasin Emre; bilir, bulent; KARAARSLAN, Numan; yasar sirin, duygu

doi:10.5455/annalsmedres.2020.03.224

In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus

Yasin Emre KAYA, (Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Bölümü, Bolu, Türkiye)

İbrahim YILMAZ, (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Numan KARAARSLAN, (Namık Kemal Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı, Tekirdağ, Türkiye)

Bülent BİLİR, (Namık Kemal Üniversitesi, Tıp Fakültesi, Dahiliye Anabilim Dalı, Tekirdağ, Türkiye)

Duygu Yaşar ŞİRİN, (Namık Kemal Üniversitesi, Fen ve Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Anabilim Dalı, Tekirdağ, Türkiye)

Hanefi ÖZBEK (İstanbul Medipol Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, İstanbul, Türkiye)

Annals of Medical Research

1 0

Yıl: 2020 Cilt: 27 Sayı: 7 Sayfa Aralığı: 1855 - 1859 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2020.03.224 İndeks Tarihi: 28-10-2020

In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus

Öz:

Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disctissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreatedsamples were statistically evaluated using an alpha signifiance value of < 0.05.Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control groupsamples (P < 0.05).Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kaya Y, YILMAZ İ, KARAARSLAN N, bilir b, yasar sirin d, özbek h (2020). In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. , 1855 - 1859. 10.5455/annalsmedres.2020.03.224
Chicago	Kaya Yasin Emre,YILMAZ İbrahim,KARAARSLAN Numan,bilir bulent,yasar sirin duygu,özbek hanefi In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. (2020): 1855 - 1859. 10.5455/annalsmedres.2020.03.224
MLA	Kaya Yasin Emre,YILMAZ İbrahim,KARAARSLAN Numan,bilir bulent,yasar sirin duygu,özbek hanefi In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. , 2020, ss.1855 - 1859. 10.5455/annalsmedres.2020.03.224
AMA	Kaya Y,YILMAZ İ,KARAARSLAN N,bilir b,yasar sirin d,özbek h In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. . 2020; 1855 - 1859. 10.5455/annalsmedres.2020.03.224
Vancouver	Kaya Y,YILMAZ İ,KARAARSLAN N,bilir b,yasar sirin d,özbek h In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. . 2020; 1855 - 1859. 10.5455/annalsmedres.2020.03.224
IEEE	Kaya Y,YILMAZ İ,KARAARSLAN N,bilir b,yasar sirin d,özbek h "In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus." , ss.1855 - 1859, 2020. 10.5455/annalsmedres.2020.03.224
ISNAD	Kaya, Yasin Emre vd. "In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus". (2020), 1855-1859. https://doi.org/10.5455/annalsmedres.2020.03.224

APA	Kaya Y, YILMAZ İ, KARAARSLAN N, bilir b, yasar sirin d, özbek h (2020). In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research, 27(7), 1855 - 1859. 10.5455/annalsmedres.2020.03.224
Chicago	Kaya Yasin Emre,YILMAZ İbrahim,KARAARSLAN Numan,bilir bulent,yasar sirin duygu,özbek hanefi In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research 27, no.7 (2020): 1855 - 1859. 10.5455/annalsmedres.2020.03.224
MLA	Kaya Yasin Emre,YILMAZ İbrahim,KARAARSLAN Numan,bilir bulent,yasar sirin duygu,özbek hanefi In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research, vol.27, no.7, 2020, ss.1855 - 1859. 10.5455/annalsmedres.2020.03.224
AMA	Kaya Y,YILMAZ İ,KARAARSLAN N,bilir b,yasar sirin d,özbek h In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research. 2020; 27(7): 1855 - 1859. 10.5455/annalsmedres.2020.03.224
Vancouver	Kaya Y,YILMAZ İ,KARAARSLAN N,bilir b,yasar sirin d,özbek h In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research. 2020; 27(7): 1855 - 1859. 10.5455/annalsmedres.2020.03.224
IEEE	Kaya Y,YILMAZ İ,KARAARSLAN N,bilir b,yasar sirin d,özbek h "In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus." Annals of Medical Research, 27, ss.1855 - 1859, 2020. 10.5455/annalsmedres.2020.03.224
ISNAD	Kaya, Yasin Emre vd. "In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus". Annals of Medical Research 27/7 (2020), 1855-1859. https://doi.org/10.5455/annalsmedres.2020.03.224