Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele

sincer, isa; Erdal, Emrah; Gücük, Adnan; bostancı, meriç emre; YILMAZ GÜNEŞ, Burçak

doi:10.30714/j-ebr.2019250349

Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele

Emrah ERDAL, (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)

İsa SİNCER, (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)

Adnan GUCUK, (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Bolu, Türkiye)

Burçak YILMAZ GÜNEŞ, (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bolu, Türkiye)

Meriç Emre BOSTANCI (Bolu Abant İzzet Baysal Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Bolu, Türkiye)

Experimental Biomedical Research

0 0

Yıl: 2019 Cilt: 2 Sayı: 2 Sayfa Aralığı: 44 - 49 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2019250349 İndeks Tarihi: 28-10-2020

Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele

Öz:

Aim: Varicocele is abnormal dilation of testis veins without unclear pathophysiology. Morphologicalstudies showed imbalance between vasoconstrictor and vasodilator mechanisms. We aimed todetermine the relationship between varicocele and cardiovascular system disorders withelectrocardiography (ECG) parameters.Methods: This is a prospective study which was conducted in a University Hospital betweenFebruary and June 2018. Thirty patients (18-45 years old) with high grade varicocele from urologyoutpatient clinic and 32 healthy volunteers for the control group were recruited to the study.Results: P-min. value was significantly higher in control group than patients with high gradevaricocele (p= 0.03). PR, QT and QTc intervals, PWD and P-max values were similar. Also, therewere no significant differences in terms of the other ECG parameters between the groups.Conclusions: In this small prospective study we have found no association between high gradevaricocele and potential electrocardiographic arrhythmia predictors namely OTd, QTc interval, PWD,Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio. Long-term follow-up and large-scale prospectivestudies are needed to confirm our results.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

[1]Nöske HD, Weidner W. Varicocele--a historical perspective. World J Urol. 1999; 17(3):151-57.
[2]Akbay E, Cayan S, Doruk E, Duce MN, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int. 2000; 86(4):490-93.
[3]Kursh ED. What is the incidence of varicocele in a fertile population? Fertil Steril. 1987; 48(3):510-11.
[4]Hendry WF, Sommerville IF, Hall RR, Pugh RC. Investigation and treatment ofthe subfertile male. Br J Urol. 1973; 45(6):684- 92.
[5]Cockett AT, Takihara H, Cosentino MJ. The varicocele. Fertil Steril. 1984; 41(1):5- 11.
[6]Yildiz O, Gul H, Ozgok Y, Onguru O, Kilciler M, Aydin A, et al. AC. Increased vasoconstrictor reactivity and decreased endothelial function in high grade varicocele; functional and morphological study. Urol Res. 2003; 31(5):323-28.
[7]Terquem A, Dadoune JP. Morphological findings in varicocele: an ultrastructural study of 30 bilateral testicular biopsies. Int J Androl. 1981; 4(5):515-31.
[8]Koyuncu H, Ergenoglu M, Yencilek F, Gulcan N, Tasdelen N, Yencilek E,et al. The evaluation of saphenofemoral insufficiency in primary adult varicocele. J Androl. 2011; 32(2):151-54.
[9]Ciaccio V, Ficola F, Ceccarelli F, Capodicasa E. Assessment of saphenofemoral junction continence in 42 patients with primary varicocele. Minerva Chir. 1995; 50(5):469-73.
[10]Karadeniz-Bilgili MY, Basar H, Simsir I, Unal B, Batislam E. Assessment of sapheno-femoral junction continence in patients with primary adolescent varicocoele. Pediatr Radiol. 2003; 33(9):603-6.
[11]Yetkin E, Kilic S, Acikgoz N, Ergin H, Aksoy Y, Sincer I,et al. Increased prevalence of varicocele in patients with coronary artery ectasia. Coron Artery Dis. 2005; 16(5):261-64.
[12]Kiliç S, Aksoy Y, Sincer I, Oğuz F, Erdil N, Yetkin E. Cardiovascular evaluation of young patients with varicocele. Fertil Steril. 2007; 88(2):369-73.
[13]Zabel M, Klingenheben T, Franz MR, Hohnloser SH. Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction: results of a prospective, longterm follow-up study. Circulation. 1998; 97(25):2543-50.
[14]Kors JA, Ritsema van Eck HJ, van Herpen G. The meaning of the Tp-Te interval and its diagnostic value. J Electrocardiol. 2008; 41(6):575-80.
[15]Perez MV, Dewey FE, Marcus R, Ashley EA, Al-Ahmad AA, Wang PJ,et al. Electrocardiographic predictors of atrial fibrillation. Am Heart J. 2009; 158(4):622- 28.
[16]Mihmanli I, Kurugoglu S, Cantasdemir M, Zulfikar Z, Halit Yilmaz M, Numan F. Color Doppler ultrasound in subclinical varicocele: an attempt to determine new criteria. Eur J Ultrasound. 2000; 12(1):43- 48.
[17]Bazett HC. An analysis of the time relations of electrocardiograms. Heart. 1920; 7: 353- 370
[18]Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, Dorantes Sánchez M, Dorticós Balea F, Zayas Molina R, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol. 2006;47(9):1828-34.
[19]Serra R, Buffone G, Costanzo G, Montemurro R, Perri P, Damiano R, et al. Varicocele in younger as risk factor for inguinal hernia and for chronic venous disease in older: preliminary results of a prospective cohort study. Ann Vasc Surg. 2013;27(3):329-31.
[20]Turhan H, Erbay AR, Yasar AS, Balci M, Bicer A, Yetkin E. Comparison of Creactive protein levels in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Am J Cardiol. 2004;94(10):1303-6.
[21]Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C. The role of nitric oxide on endothelial function. Curr Vasc Pharmacol. 2012;10(1):4-18.
[22]Zeinali M, Hadian Amree A, Khorramdelazad H, Karami H, Abedinzadeh M. Inflammatory and antiinflammatory cytokines in the seminal plasma of infertile men suffering from varicocele. Andrologia. 2017;49(6):1-4.
[23]Court O, Kumar A, Parrillo JE, Kumar A. Clinical review: Myocardial depression in sepsis and septic shock. Crit Care. 2002;6(6):500-8.
[24]de Bruyne MC, Hoes AW, Kors JA, Hofman A, van Bemmel JH, Grobbee DE. QTc dispersion predicts cardiac mortality in the elderly: the Rotterdam Study. Circulation. 1998;97(5):467-72.
[25]Somberg JC, Molnar J. Usefulness of QT dispersion as an electrocardiographically derived index. Am J Cardiol. 2002;89(3):291-94.
[26]Haarmark C, Hansen PR, Vedel-Larsen E, Pedersen SH, Graff C, Andersen MP, et al. The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for STsegment elevation myocardial infarction. J Electrocardiol. 2009;42(6):555-60.
[27]Gialafos JE, Dilaveris PE, Gialafos EJ, George KA, Dimitrios JR, Filippos T, et al. P wave dispersion: A valuable electrocardiographic marker for the prediction of paroxysmal lone atrial fibrillation. Ann Noninvasive Electrocardiol.1999; 4(1): 39-45.
[28]Gökçe M, Görenek B. P Wave Dispersion. Turkish Journal of Arrhythmia, Pacing and Electrophysiology. 2003; 3: 136-43.

APA	Erdal E, sincer i, Gücük A, YILMAZ GÜNEŞ B, bostancı m (2019). Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. , 44 - 49. 10.30714/j-ebr.2019250349
Chicago	Erdal Emrah,sincer isa,Gücük Adnan,YILMAZ GÜNEŞ Burçak,bostancı meriç emre Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. (2019): 44 - 49. 10.30714/j-ebr.2019250349
MLA	Erdal Emrah,sincer isa,Gücük Adnan,YILMAZ GÜNEŞ Burçak,bostancı meriç emre Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. , 2019, ss.44 - 49. 10.30714/j-ebr.2019250349
AMA	Erdal E,sincer i,Gücük A,YILMAZ GÜNEŞ B,bostancı m Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. . 2019; 44 - 49. 10.30714/j-ebr.2019250349
Vancouver	Erdal E,sincer i,Gücük A,YILMAZ GÜNEŞ B,bostancı m Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. . 2019; 44 - 49. 10.30714/j-ebr.2019250349
IEEE	Erdal E,sincer i,Gücük A,YILMAZ GÜNEŞ B,bostancı m "Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele." , ss.44 - 49, 2019. 10.30714/j-ebr.2019250349
ISNAD	Erdal, Emrah vd. "Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele". (2019), 44-49. https://doi.org/10.30714/j-ebr.2019250349

APA	Erdal E, sincer i, Gücük A, YILMAZ GÜNEŞ B, bostancı m (2019). Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. Experimental Biomedical Research, 2(2), 44 - 49. 10.30714/j-ebr.2019250349
Chicago	Erdal Emrah,sincer isa,Gücük Adnan,YILMAZ GÜNEŞ Burçak,bostancı meriç emre Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. Experimental Biomedical Research 2, no.2 (2019): 44 - 49. 10.30714/j-ebr.2019250349
MLA	Erdal Emrah,sincer isa,Gücük Adnan,YILMAZ GÜNEŞ Burçak,bostancı meriç emre Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. Experimental Biomedical Research, vol.2, no.2, 2019, ss.44 - 49. 10.30714/j-ebr.2019250349
AMA	Erdal E,sincer i,Gücük A,YILMAZ GÜNEŞ B,bostancı m Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. Experimental Biomedical Research. 2019; 2(2): 44 - 49. 10.30714/j-ebr.2019250349
Vancouver	Erdal E,sincer i,Gücük A,YILMAZ GÜNEŞ B,bostancı m Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele. Experimental Biomedical Research. 2019; 2(2): 44 - 49. 10.30714/j-ebr.2019250349
IEEE	Erdal E,sincer i,Gücük A,YILMAZ GÜNEŞ B,bostancı m "Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele." Experimental Biomedical Research, 2, ss.44 - 49, 2019. 10.30714/j-ebr.2019250349
ISNAD	Erdal, Emrah vd. "Evaluation of electrocardiographic ventricular and atrial repolarization markers in patients with high grade varicocele". Experimental Biomedical Research 2/2 (2019), 44-49. https://doi.org/10.30714/j-ebr.2019250349