Yıl: 2019 Cilt: 4 Sayı: 4 Sayfa Aralığı: 106 - 109 Metin Dili: İngilizce DOI: 10.4274/BMB.galenos.2019.09.014 İndeks Tarihi: 29-10-2020

A Rare Case: Malignant Granular Cell Tumor in Axillary Region

Öz:
Granular cell tumors (GCT) are rare soft tissue tumors. Although it isfrequently seen in the upper extremity, it can be seen anywhere in thehuman body. The majority of tumor cases are benign and approximately2% are malignant. It is seen in the breast at a rate of 5-8%. They presentwith a slow growing, painless, mobile mass. The definitive diagnosis ismade histopathologically and the treatment is wide excision. A 75-yearold woman presented with an ulcerated exudative mass in the right axilla.Mastectomy and axillary dissection were performed by general surgery 8months ago for BIRADS 3 mass that was determined on mammographyin the right breast. Breast specimen was identified as a phyllodestumor. GCT was detected in five of thirty lmph nodes in the axilla.Incisional biopsy was performed on the axillary mass. Histopathologicalmeasurements showed S-100 and CD68 positivity, eosinophilic stainingin tumor cells and pleomorphic nuclei with marked nucleolus. The tumorwas removed with wide excision and the defect area was closed witha splint thickness skin graft. The pathological measurements revealedthat the GCT in the axilla was not a breast metastasis, it was actuallymalignant GCT which was originated from skin. Ki-67 proliferation indexwas found as 10%. Surgical margins were seen as tumor free. There wereno complications in the postoperative follow-up. GCTs in the axilla aregenerally seen as a result of breast metastasis and the vast majority arebenign. Malignant skin-derived GCT is a rare case.
Anahtar Kelime:

Nadir Bir Olgu: Aksiller Bölgede Malign Granüler Hücreli Tümör

Öz:
Granüler hücreli tümör (GHT) nadir görülen yumuşak doku tümörüdür. Sıklıkla üst ekstremitede görülse de vücudun herhangi bir yerinde görülebilir. Tümör olgularının büyük çoğunluğu benigndir yaklaşık %2’lik kısmı maligndir. Tümör %5-8 oranında memede görülmektedir. Yavaş büyüyen, ağrısız, mobil kitle ile ortaya çıkar. Kesin tanı histopatolojik olarak konulmaktadır. Tedavisi geniş eksizyondur. Yetmiş beş yaşında kadın hasta sağ aksillada ülsere eksüdalı kitle ile başvurdu. Sekiz ay önce sağ memedeki mamografi sonucu BIRADS 3 olan kitle için genel cerrahi tarafından mastektomi ve aksiller diseksiyon yapıldı. Meme patolojisi filloides tümör olarak belirlendi. Aksilladaki otuz lenf nodundan beş tanesinde GHT’ye rastlandı. Aksilladaki kitleye insizyonel biyopsi yapıldı. Histopatolojik ölçümlerde S-100 ve CD-68 pozitifliği, tümör hücrelerinde eozinofilik boyanma ile belirgin nükleolusua sahip pleomorfik nükleuslar görülmüştür. Tümör geniş eksizyonla çıkartıldı defekt alanı kısmi kalınlıkta deri greft ile kapatıldı. Patolojik ölçümlerde aksilladaki GHT’nin meme metastazı olarak değil, deri kaynaklı malign GHT’si olduğu belirlendi. Ki67 proliferasyon indeksi %10 olarak saptandı. Cerrahi sınırlar salim olarak görüldü. Hastanın postoperatif takiplerinde herhangi bir komplikasyona rastlanmadı. Aksilladaki GHT’ler genel olarak meme metastazı sonucu görülmektedir ve büyük çoğunluğu benigndir. Malign deri kaynaklı GHT nadir görülen bir olgudur.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA TATAR B, GELBAL C, Sezgic M, Karakol P, USLU C, Kabul S (2019). A Rare Case: Malignant Granular Cell Tumor in Axillary Region. , 106 - 109. 10.4274/BMB.galenos.2019.09.014
Chicago TATAR Burak Ergün,GELBAL Caner,Sezgic Melihcan,Karakol Percin,USLU Can,Kabul Selva A Rare Case: Malignant Granular Cell Tumor in Axillary Region. (2019): 106 - 109. 10.4274/BMB.galenos.2019.09.014
MLA TATAR Burak Ergün,GELBAL Caner,Sezgic Melihcan,Karakol Percin,USLU Can,Kabul Selva A Rare Case: Malignant Granular Cell Tumor in Axillary Region. , 2019, ss.106 - 109. 10.4274/BMB.galenos.2019.09.014
AMA TATAR B,GELBAL C,Sezgic M,Karakol P,USLU C,Kabul S A Rare Case: Malignant Granular Cell Tumor in Axillary Region. . 2019; 106 - 109. 10.4274/BMB.galenos.2019.09.014
Vancouver TATAR B,GELBAL C,Sezgic M,Karakol P,USLU C,Kabul S A Rare Case: Malignant Granular Cell Tumor in Axillary Region. . 2019; 106 - 109. 10.4274/BMB.galenos.2019.09.014
IEEE TATAR B,GELBAL C,Sezgic M,Karakol P,USLU C,Kabul S "A Rare Case: Malignant Granular Cell Tumor in Axillary Region." , ss.106 - 109, 2019. 10.4274/BMB.galenos.2019.09.014
ISNAD TATAR, Burak Ergün vd. "A Rare Case: Malignant Granular Cell Tumor in Axillary Region". (2019), 106-109. https://doi.org/10.4274/BMB.galenos.2019.09.014
APA TATAR B, GELBAL C, Sezgic M, Karakol P, USLU C, Kabul S (2019). A Rare Case: Malignant Granular Cell Tumor in Axillary Region. Bağcılar Tıp Bülteni, 4(4), 106 - 109. 10.4274/BMB.galenos.2019.09.014
Chicago TATAR Burak Ergün,GELBAL Caner,Sezgic Melihcan,Karakol Percin,USLU Can,Kabul Selva A Rare Case: Malignant Granular Cell Tumor in Axillary Region. Bağcılar Tıp Bülteni 4, no.4 (2019): 106 - 109. 10.4274/BMB.galenos.2019.09.014
MLA TATAR Burak Ergün,GELBAL Caner,Sezgic Melihcan,Karakol Percin,USLU Can,Kabul Selva A Rare Case: Malignant Granular Cell Tumor in Axillary Region. Bağcılar Tıp Bülteni, vol.4, no.4, 2019, ss.106 - 109. 10.4274/BMB.galenos.2019.09.014
AMA TATAR B,GELBAL C,Sezgic M,Karakol P,USLU C,Kabul S A Rare Case: Malignant Granular Cell Tumor in Axillary Region. Bağcılar Tıp Bülteni. 2019; 4(4): 106 - 109. 10.4274/BMB.galenos.2019.09.014
Vancouver TATAR B,GELBAL C,Sezgic M,Karakol P,USLU C,Kabul S A Rare Case: Malignant Granular Cell Tumor in Axillary Region. Bağcılar Tıp Bülteni. 2019; 4(4): 106 - 109. 10.4274/BMB.galenos.2019.09.014
IEEE TATAR B,GELBAL C,Sezgic M,Karakol P,USLU C,Kabul S "A Rare Case: Malignant Granular Cell Tumor in Axillary Region." Bağcılar Tıp Bülteni, 4, ss.106 - 109, 2019. 10.4274/BMB.galenos.2019.09.014
ISNAD TATAR, Burak Ergün vd. "A Rare Case: Malignant Granular Cell Tumor in Axillary Region". Bağcılar Tıp Bülteni 4/4 (2019), 106-109. https://doi.org/10.4274/BMB.galenos.2019.09.014