Objective: This study was conducted to determine the relationship between job satisfaction and organizational trust of nurses’ personal and professional characteristics.Material and Methods: This was a descriptive, cross-sectional study. Three forms were used: 1- questions about demographic characteristics, 2- Minnesota job satisfaction scale, and 3- organizational confidence scale. Data were obtained through face-to-face interviews with the nurses. The study was conducted with 456 nurses who met the inclusion criteria. Quantitative data were analyzed using a computer. T-test, one-way ANOVA, and Pearson and Spearman correlation analyses were used. Statistical significance was accepted as p<0.05. (ethics committee permission number: 2017/381)Results: As the organizational trust levels of the nurses increased, job satisfaction levels increased (p<0.01). As age, years in the occupation, and years of working in the institution/service increased, job satisfaction scores, trust in managers, and trust in the institutions increased (p<0.01). There is a positive relationship between continuous day shift work, satisfaction with the unit, job satisfaction, and organizational trust scores. Satisfaction with the department alone significantly increased both job satisfaction and organizational trust scores (p=0.001). The sub-dimension of trust in the colleagues was not affected by any factor other than being satisfied with the unit and the department studied (p>0.05).Conclusion: Our results show that the relationship between the variables can vary. Education, gender, marital status, and economic status are not the factors affecting the organizational trust. Being married is a factor that increases the job satisfaction score. Trust in the colleagues varies according to the unit studied.