Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics

YUCEL OZCIRPAN, CIGDEM; Evrenol Öçal, Simge; Koç, Gülten; SİMSEK CETİNKAYA, SAHIKA

doi:10.5152/ArcHealthSciRes.2020.589394

Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics

Simge EVRENOL ÖÇAL, (İzmir Katip Çelebi Üniversitesi, Sağlık Bilimleri Fakültesi, Doğum ve Kadın Hastalıkları Hemşireliği Anabilim Dalı, İzmir, Türkiye)

Şahika ŞİMŞEK ÇETİNKAYA, (Kastamonu Üniversitesi, Fazıl Boyner Sağlık Bilimleri Fakültesi, Ebelik Bölümü, Kastamonu, Türkiye)

Çiğdem YÜCEL, (Hacettepe Üniversitesi, Hemşirelik Fakültesi, Doğum ve Kadın Hastalıkları Hemşireliği Anabilim Dalı, Ankara, Türkiye)

Gülten KOÇ (Hacettepe Üniversitesi, Hemşirelik Fakültesi, Doğum ve Kadın Hastalıkları Hemşireliği Anabilim Dalı, Ankara, Türkiye)

Archives of health science and research (Online)

8 2

Yıl: 2020 Cilt: 7 Sayı: 2 Sayfa Aralığı: 201 - 206 Metin Dili: İngilizce DOI: 10.5152/ArcHealthSciRes.2020.589394 İndeks Tarihi: 30-10-2020

Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics

Öz:

Mitochondrial diseases increase mortality and morbidity caused by mutations in mitochondrial DNA (mtDNA) or functional gene disorders of mitochondria. Hereditary mutations in mtDNA are an important cause of genetic diseases for which there is no effective treatment and are transmitted from generation to generation. Mutations in DNA have an important role in infertility or other reproductive anomalies that occur later in life by affecting oocyte functions as well as negatively affecting vital organs. With the development of technology, one of the new treatment approaches developed for mitochondrial diseases is mitochondrial gene replacement therapy (MRT). MRT allows women who are carriers of mtDNA mutations to have a genetically healthy child. In this review, MRT, its effects, nursing dimensions, and ethical relationship are discussed.

Anahtar Kelime:

Kalıtsal Mitokondriyal Hastalıkların Önlenmesinde Gen Replasmanı: Üç Ebeveynli Bebekler ve Etik

Öz:

Mitokondriyal hastalıklar, mitokondriyal DNA (mtDNA)’daki mutasyonlardan veya mitokondrinin fonksiyonel gen bozukluklarından kaynaklanan mortalite ve morbiditeyi arttıran hastalıklardır. mtDNA’daki kalıtsal mutasyonlar etkili bir tedavinin bulunmadığı genetik hastalıkların önemli bir sebebidir ve nesilden nesile aktarılmaktadır. DNA’da meydana gelen mutasyonlar, hayati öneme sahip organları olumsuz etkilediği gibi oosit fonksiyonlarını da etkileyerek infertilite ya da yaşamın ilerleyen dönemlerinde ortaya çıkan diğer üreme anomalilerinde önemli bir rol oynamaktadır. Teknolojinin gelişmesiyle beraber mitokondriyal hastalıklara yönelik geliştirilen yeni yaklaşımlardan biri de mitokondriyal gen replasman tedavisi (MRT)’dir. MRT, mtDNA mutasyonlarının taşıyıcısı olan kadınların genetik olarak sağlıklı bir çocuğa sahip olmasına olanak tanımaktadır. Bu derlemede mitokondriyal gen replasman tedavisi, mitokondriyal gen replasman tedavisinin etkileri, hemşirelik boyutu, mitokondriyal gen replasman tedavisinin etik boyutu ve hemşirelikle ilişkisi tartışılmıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Evrenol Öçal S, SİMSEK CETİNKAYA S, YUCEL OZCIRPAN C, Koç G (2020). Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. , 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
Chicago	Evrenol Öçal Simge,SİMSEK CETİNKAYA SAHIKA,YUCEL OZCIRPAN CIGDEM,Koç Gülten Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. (2020): 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
MLA	Evrenol Öçal Simge,SİMSEK CETİNKAYA SAHIKA,YUCEL OZCIRPAN CIGDEM,Koç Gülten Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. , 2020, ss.201 - 206. 10.5152/ArcHealthSciRes.2020.589394
AMA	Evrenol Öçal S,SİMSEK CETİNKAYA S,YUCEL OZCIRPAN C,Koç G Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. . 2020; 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
Vancouver	Evrenol Öçal S,SİMSEK CETİNKAYA S,YUCEL OZCIRPAN C,Koç G Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. . 2020; 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
IEEE	Evrenol Öçal S,SİMSEK CETİNKAYA S,YUCEL OZCIRPAN C,Koç G "Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics." , ss.201 - 206, 2020. 10.5152/ArcHealthSciRes.2020.589394
ISNAD	Evrenol Öçal, Simge vd. "Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics". (2020), 201-206. https://doi.org/10.5152/ArcHealthSciRes.2020.589394

APA	Evrenol Öçal S, SİMSEK CETİNKAYA S, YUCEL OZCIRPAN C, Koç G (2020). Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. Archives of health science and research (Online), 7(2), 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
Chicago	Evrenol Öçal Simge,SİMSEK CETİNKAYA SAHIKA,YUCEL OZCIRPAN CIGDEM,Koç Gülten Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. Archives of health science and research (Online) 7, no.2 (2020): 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
MLA	Evrenol Öçal Simge,SİMSEK CETİNKAYA SAHIKA,YUCEL OZCIRPAN CIGDEM,Koç Gülten Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. Archives of health science and research (Online), vol.7, no.2, 2020, ss.201 - 206. 10.5152/ArcHealthSciRes.2020.589394
AMA	Evrenol Öçal S,SİMSEK CETİNKAYA S,YUCEL OZCIRPAN C,Koç G Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. Archives of health science and research (Online). 2020; 7(2): 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
Vancouver	Evrenol Öçal S,SİMSEK CETİNKAYA S,YUCEL OZCIRPAN C,Koç G Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics. Archives of health science and research (Online). 2020; 7(2): 201 - 206. 10.5152/ArcHealthSciRes.2020.589394
IEEE	Evrenol Öçal S,SİMSEK CETİNKAYA S,YUCEL OZCIRPAN C,Koç G "Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics." Archives of health science and research (Online), 7, ss.201 - 206, 2020. 10.5152/ArcHealthSciRes.2020.589394
ISNAD	Evrenol Öçal, Simge vd. "Gene Replacement in the Prevention of Hereditary Mitochondrial Diseases: Three Parent Babies and Ethics". Archives of health science and research (Online) 7/2 (2020), 201-206. https://doi.org/10.5152/ArcHealthSciRes.2020.589394