OBJECTIVE: The likelihood of malignancy in lymphadenopathies is 1-3% and the mostly lymphomas are seen. Ultrasonography may be helpful in malignancy with some findings in the differential diagnosis of the disease. In cases where malignancy is suspected, which the diagnosis is incomplete, the biopsy is required. In this study, we aimed to compare sociodemographic data of clinical, laboratory, ultrasound findings and histopathology of patients with pathologic lymphadenopathy. MATERIAL AND METHODS: For this purpose, among 857 lymphadenopathic patients (328 females-529 males) who were admitted to Kahramanmaras Sütçü İmam University Medical Faculty Hospital between January 2014 and September 2016, 50 patients (39 male, 11 female) were retrospectively evaluated. RESULTS: The ages of the 50 patients included in the study ranged from 12 months to 192 months. Lymphadenopathy size was over 3 cm in 24 of the patients. Of the lymphadenopathies, 35 had cervical and 15 had non-cervical localization. Among these patients, it was diagnosed with reactive in 35 patients and non-reactive in 15 patients. Of the patients, 38 had benign disease and malignancy was observed in 12 patients. As a result of the statistical analyzes, a significantly correlated relationship was found between pathology results and ultrasonography as well as lymphadenopathy size and the size observed in ultrasonography (p<0.05). In our study, in terms of comparison for usg feature and fever between benign and malign, fever was seen in 12 (31.6%) of benign patients, and 9 (75%) of malignant patients, as there was a significant difference between groups in terms of the presence of fever (p <0.05). CONCLUSIONS: After examining medical history and physical examination of the patients with lymphadenopathy, lymphadenopathy should be investigated for signs of a serious illness.