Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate

sönmez, mehmet giray; GÜLPINAR, Ömer; DEMİRELLİ, Erhan; Bedük, Yaşar; HALİLOGLU, AHMET HAKAN; KÜPELİ, Sadettin

doi:10.30565/ medalanya.407858

Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate

Erhan DEMİRELLİ, (Giresun Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Giresun, Türkiye)

Ahmet Hakan HALİLOĞLU, (Ufuk Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Ömer GÜLPINAR, (Ankara Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Mehmet Giray SÖNMEZ, (Adres yazılmamış)

Yaşar BEDÜK, (Ankara Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Sadettin KÜPELİ (Ufuk Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Ankara, Türkiye)

Acta Medica Alanya

2 0

Yıl: 2018 Cilt: 2 Sayı: 3 Sayfa Aralığı: 182 - 187 Metin Dili: İngilizce DOI: 10.30565/ medalanya.407858 İndeks Tarihi: 31-10-2020

Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate

Öz:

Aim: In the present study we aimed to check the impact of maximal androgen deprivation therapy (MADT) on cellular blood components such as hemoglobin (Hb) andhematocrit (Htc) fasting blood glucose (FBG), serum lipid values and bone mineraldensity (BMD) in locally advanced prostate cancer.Patients and Methods: Having been treated with maximal androgen blockade therapy, thirty-nine patients' initial values and at the twelfth month values of hemoglobin(Hb), hematocrit (Htc), FBG, total cholesterol (tChol), triglyceride (TG), high densitylipoprotein (HDL), low density lipoprotein (LDL) and spine BMD were recorded. Statistical comparisons of initial and at the twelfth month values were performed.Results: A statistically significant decrease was recorded in Hb and BMD valuesafter one year MADT. On the other hand, TG, tChol, LDL, HDL and FBG valuesshowed a statistically significant increase. Although Hb levels were significantly reduced, none of our patients developed symptoms of anemia. Fourteen of 37 patientswhose FBG levels were under 110 mg/dl before treatment, increased over 110 mg/dlat the twelfth month of treatment. Seven patients developed diabetes mellitus (DM)after treatment. Moreover, T score evaluation revealed newly developed osteoporosis in 4 patients. All of the patients with developed osteoporosis had osteopenicT score values before treatment. No bone fractures occurred in any of our patients.Conclusion: Our study points out the increase of FBG related to the treatment ofMADT. Decrease in BMD is higher in previously osteopenic patients. The lack of bonefracture and anemia symptoms might be considered as a result of evaluation of theearly data on MADT.

Anahtar Kelime:

Lokal İleri Evre Prostat Kanserinde Maksimal Androjen Blokaj Tedavisinin Hematolojik, Biyokimyasal Ve Kemik Yoğunluğu Parametreleri Üzerine Etkileri

Öz:

Amaç: Bu çalışmanın amacı, lokal olarak ilerlemiş prostat kanserinde maksimal androjen blokajı tedavisinin (MABT) hemoglobin (Hb) ve hematokrit (Htc) değerleri ile açlık kan şekeri (AKŞ), serum lipid değerleri ve kemik mineral yoğunluğu (KMD) üzerindeki etkisini kontrol etmektir. Hastalar ve Yöntemler: MABT ile tedavi edilen 39 hastanın başlangıç ve onikinci aydaki hemoglobin, hematokrit, açlık kan şekeri, total kolesterol (tChol), trigliserit (TG), yüksek yoğunluklu lipoprotein (HDL), düşük yoğunluklu lipoprotein (LDL) ve omurga KMD değerleri kaydedildi. İlk ve onikinci aydaki değerlerin istatistiksel karşılaştırmaları yapıldı. Bulgular: Bir yıllık MABT sonrası Hb ve KMD değerlerinde istatistiksel olarak anlamlı azalma kaydedildi. Öte yandan, TG, tChol, LDL, HDL ve AKŞ değerleri istatistiksel olarak anlamlı bir artış gösterdi. Hb düzeyleri önemli ölçüde azalmış olmasına rağmen, hastalarımızın hiçbirinde anemi belirtileri gelişmedi. Tedaviden önce FBG seviyeleri 110 mg / dl'nin altında olan 37 hastanın 14'ü tedavinin onikinci ayında 110 mg / dl'nin üzerine çıktı. Yedi hastada tedaviden sonra diyabetes mellitus (DM) gelişti. Dahası, T skoru değerlendirmesi 4 hastada yeni gelişen osteoporozu ortaya koymuştur. Osteoporoz gelişen tüm hastaların tedaviden önce osteopenik T skoru değerleri vardı. Hiç bir hastamızda kemik kırığı oluşmadı. Sonuç: Çalışmamız MABT bağlı AKŞ artışını göstermektedir. KMD değerindeki azalma, daha önce osteopenik olan hastalarda daha yüksektir. Kemik kırığı ve anemi semptomlarının olmaması, MABT ile ilgili erken verilerin değerlendirilmesinin bir sonucu olarak düşünülebilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DEMİRELLİ E, HALİLOGLU A, GÜLPINAR Ö, sönmez m, Bedük Y, KÜPELİ S (2018). Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. , 182 - 187. 10.30565/ medalanya.407858
Chicago	DEMİRELLİ Erhan,HALİLOGLU AHMET HAKAN,GÜLPINAR Ömer,sönmez mehmet giray,Bedük Yaşar,KÜPELİ Sadettin Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. (2018): 182 - 187. 10.30565/ medalanya.407858
MLA	DEMİRELLİ Erhan,HALİLOGLU AHMET HAKAN,GÜLPINAR Ömer,sönmez mehmet giray,Bedük Yaşar,KÜPELİ Sadettin Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. , 2018, ss.182 - 187. 10.30565/ medalanya.407858
AMA	DEMİRELLİ E,HALİLOGLU A,GÜLPINAR Ö,sönmez m,Bedük Y,KÜPELİ S Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. . 2018; 182 - 187. 10.30565/ medalanya.407858
Vancouver	DEMİRELLİ E,HALİLOGLU A,GÜLPINAR Ö,sönmez m,Bedük Y,KÜPELİ S Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. . 2018; 182 - 187. 10.30565/ medalanya.407858
IEEE	DEMİRELLİ E,HALİLOGLU A,GÜLPINAR Ö,sönmez m,Bedük Y,KÜPELİ S "Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate." , ss.182 - 187, 2018. 10.30565/ medalanya.407858
ISNAD	DEMİRELLİ, Erhan vd. "Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate". (2018), 182-187. https://doi.org/10.30565/ medalanya.407858

APA	DEMİRELLİ E, HALİLOGLU A, GÜLPINAR Ö, sönmez m, Bedük Y, KÜPELİ S (2018). Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. Acta Medica Alanya, 2(3), 182 - 187. 10.30565/ medalanya.407858
Chicago	DEMİRELLİ Erhan,HALİLOGLU AHMET HAKAN,GÜLPINAR Ömer,sönmez mehmet giray,Bedük Yaşar,KÜPELİ Sadettin Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. Acta Medica Alanya 2, no.3 (2018): 182 - 187. 10.30565/ medalanya.407858
MLA	DEMİRELLİ Erhan,HALİLOGLU AHMET HAKAN,GÜLPINAR Ömer,sönmez mehmet giray,Bedük Yaşar,KÜPELİ Sadettin Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. Acta Medica Alanya, vol.2, no.3, 2018, ss.182 - 187. 10.30565/ medalanya.407858
AMA	DEMİRELLİ E,HALİLOGLU A,GÜLPINAR Ö,sönmez m,Bedük Y,KÜPELİ S Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. Acta Medica Alanya. 2018; 2(3): 182 - 187. 10.30565/ medalanya.407858
Vancouver	DEMİRELLİ E,HALİLOGLU A,GÜLPINAR Ö,sönmez m,Bedük Y,KÜPELİ S Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate. Acta Medica Alanya. 2018; 2(3): 182 - 187. 10.30565/ medalanya.407858
IEEE	DEMİRELLİ E,HALİLOGLU A,GÜLPINAR Ö,sönmez m,Bedük Y,KÜPELİ S "Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate." Acta Medica Alanya, 2, ss.182 - 187, 2018. 10.30565/ medalanya.407858
ISNAD	DEMİRELLİ, Erhan vd. "Effects of Maximal Androgen Blockade Therapy on Hematological, Biochemical and Bone Density Parameters in Locally Advanced Prostate". Acta Medica Alanya 2/3 (2018), 182-187. https://doi.org/10.30565/ medalanya.407858