Yıl: 2019 Cilt: 4 Sayı: 1 Sayfa Aralığı: 11 - 14 Metin Dili: İngilizce İndeks Tarihi: 02-11-2020

Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis

Öz:
Introduction: Acute viral gastroenteritis is the second most common cause of high morbidity and mortality in childhood. Viral gastroenteritisis the most common cause of severe diarrhea and associated hospitalizations especially in toddlers. It has been shown that the administration of 20mg of zinc daily during acute diarrhea reduces the duration of watery diarrhea by 25% and it has been reported to have protective and therapeuticeffects in the acute period. The aim of this study is to retrospectively determine the beneficial effects of oral zinc supplementation on the severityand duration of complaints of toddlers who were treated in our clinic with the diagnosis of acute viral gastroenteritis.Methods: Toddlers who were hospitalized in the Department of Pediatrics for acute viral gastroenteritis between October 2016 and March 2018were included in the study. The study was retrospective and the data of the patients were obtained from the patient files. The diagnosis of acuteviral gastroenteritis was made by detecting the adenovirus-rotavirus antigen in the fresh stool specimens. The patients were divided into twogroups. Group 1: patients who received zinc supplementation in addition to support treatment. Group 2: patients who received only supportivetherapy.Results: The mean number of vomiting was 3.60 / day and watery diarrhea was 5.20 / day in group-1 while number of vomiting was 6.1 / dayand watery diarrhea was 8.9 / day in group-2 in the 36th hour during treatment. The tolerability of oral feeding at 36 th hour was 49.39% ( 41) ingroup-1 and 45.07% (32) in group-2. The mean number of vomiting and watery diarrhea in group-1 cases at 72th hours was 1.2 / day and 4.30 /day, while in group-2 cases, 3.90 / day and 7.20 / day.Conclusions: Although the physiopathology of the effects of zinc on gastroenteritis is not yet fully understood, diarrhea is seen both as a causeand as a result of zinc deficiency. The fact that patients with gastroenteritis benefit from zinc support suggests that zinc enhances this effect byincreasing intestinal immunity.
Anahtar Kelime:

Akut viral gastroenteritlerde oral çinko kullanımının hastalığın semptomları ve süresine etkisinin değerlendirilmesi

Öz:
Giriş: Akut viral gastroenteritler çocukluk çağında yüksek morbidite ve mortalitenin en sık ikinci sebebidir. Özellikle oyun çağı ve okul çağı çocukluk döneminde tüm dünyada şiddetli ishallerin ve buna bağlı hastane yatışları ile bebek ölümlerinin en sık nedeni viral gastroenteritlerdir. Akut ishal sırasında günlük 20 mg çinko verilmesinin sulu dışkılama süresini %25 azalttığı gösterilmiştir ve akut dönemde koruyucu ve terapotik etkileri olduğu bildirilmiştir. Bu çalışmanın amacı, çocukluk çağında morbiditesi ve mortalitesi yüksek hastalıkların başında gelen akut viral gastroenterit tanısıyla kliniğimizde tedavi edilen 2-5 yaş arası oyun çağı çocuk hastaların yakınmalarının şiddeti ve süresi üzerinde oral çinko kullanımının etkisini retrospektif olarak belirlemektir. Yöntem: Akut viral gastroenterit tanısıyla Ekim 2016 – Mart 2018 tarihleri arasında yatırılarak tedavi edilen 2-5 yaş arası oyun çağı dönemindeki çocuk hastalar çalışmaya alındı.Çalışma retrospektif olup hastaların verileri hasta dosyalarından elde edildi.Akut viral gastroenteri tanısı taze dışkı örneğinde adenovirüs-rotavirüs antijeni saptanması ile konuldu.Hastaların verileri Çinko tedavisi alanlar (Grup-1) ile çinko tedavisi almayanlar (Grup-2) arasında karşılaştırıldı. Bulgular: Çinko tedavisi verilen grup-1’deki olguların 36.saatteki ortalama kusma ve dışkılama sayısı 3,6/gün ve 5,2/gün iken çinko almayan grup-2 olgularınki 6,10/gün ve 8,90/gün idi.36. Saatte oral beslenmeyi tolere etme grup-1 de % 49.39 (41) iken grup-2 de % 45.07 (32) idi.72.saatte grup-1 olguların ortalama kusma ve dışkılama sayısı 1,20/gün ve 4,30/gün iken grup-2 olgularda 3,90/gün ve 7.20/gün idi. Sonuç: Çinkonun gastroenteritler üzerindeki etkilerinin fizyopatolojisi henüz tam olarak anlaşılamamış olmakla birlikte ishaller, hem çinko eksikliğinin bir nedeni, hem de bir sonucu olarak görülmektedir. Gastrenteritli olguların çinko desteğinden fayda görmesi, çinkonun intestinal immuniteyi arttırarak bu etkiyi sağladığını düşündürmektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA el ç, çelikkaya m (2019). Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. , 11 - 14.
Chicago el çiğdem,çelikkaya mehmet emin Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. (2019): 11 - 14.
MLA el çiğdem,çelikkaya mehmet emin Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. , 2019, ss.11 - 14.
AMA el ç,çelikkaya m Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. . 2019; 11 - 14.
Vancouver el ç,çelikkaya m Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. . 2019; 11 - 14.
IEEE el ç,çelikkaya m "Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis." , ss.11 - 14, 2019.
ISNAD el, çiğdem - çelikkaya, mehmet emin. "Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis". (2019), 11-14.
APA el ç, çelikkaya m (2019). Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. Aile Hekimliği ve Palyatif Bakım, 4(1), 11 - 14.
Chicago el çiğdem,çelikkaya mehmet emin Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. Aile Hekimliği ve Palyatif Bakım 4, no.1 (2019): 11 - 14.
MLA el çiğdem,çelikkaya mehmet emin Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. Aile Hekimliği ve Palyatif Bakım, vol.4, no.1, 2019, ss.11 - 14.
AMA el ç,çelikkaya m Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. Aile Hekimliği ve Palyatif Bakım. 2019; 4(1): 11 - 14.
Vancouver el ç,çelikkaya m Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis. Aile Hekimliği ve Palyatif Bakım. 2019; 4(1): 11 - 14.
IEEE el ç,çelikkaya m "Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis." Aile Hekimliği ve Palyatif Bakım, 4, ss.11 - 14, 2019.
ISNAD el, çiğdem - çelikkaya, mehmet emin. "Evaluation of the effects of zinc supplementation on the symptoms and duration of the disease in acute viral gastroenteritis". Aile Hekimliği ve Palyatif Bakım 4/1 (2019), 11-14.