Yıl: 2019 Cilt: 4 Sayı: 2 Sayfa Aralığı: 74 - 78 Metin Dili: İngilizce İndeks Tarihi: 02-11-2020

Pregnancy and Toxoplasmosis: should screening be a routine practice?

Öz:
Because infectious agents can reach the fetus through the placenta, pregnancy is regarded as a particular period for contagious diseases. Identificationof infections during pregnancy and appropriate treatment can prevent fetal disorders. For this purpose, to avoid their harmful effects on fetus andnewborn, various infectious diseases are screened during pregnancy. Toxoplasma gondii infection in pregnancy is transmitted through thetransplacental pathway leading to severe neurological sequelae such as fetal abortion, stillbirth, intrauterine growth retardation, cranial calcifications,blindness, deafness, and mental retardation. This can lead to serious social and economic problems for the family and the infant, as well as society. Toprevent these sequelae, infections during pregnancy need to be identified and appropriately treated. There are different opinions and practices in theworld regarding the screening of T. gondii during pregnancy follow-up. This review aimed to assess the seroprevalence of T. gondii infection duringgestation in Turkey and the world, its effects on the fetus, ways of protection, and suggestions about screening in the world and in Turkey in light ofthe literature, so that this becomes a guide for clinical practice for physicians.
Anahtar Kelime:

Gebelik ve Toksoplazmoz: Rutin tarama yapılmalı mı?

Öz:
Gebelik, etkenlerin transplasental yolla fetüse ulaşıp, hastalık yapabilme potansiyelleri nedeniyle enfeksiyon hastalıkları için özel bir dönemdir. Enfeksiyon etkenlerinin anneden bebeğe geçerek hastalık oluşturmalarının önlenmesi, gebelik sırasında tanınmaları ve uygun şekilde tedavi edilmelerine bağlıdır. Bu amaçla, gebelik sırasında çeşitli enfeksiyon hastalıklar için tarama yapılmakta, fetüs ve yenidoğanda olabilecek hastalık ve olumsuz etkiler önlenmeye çalışılmaktadır. Gebelerde T. gondii taraması konusunda dünyada farklı görüş ve uygulamalar vardır. Bu derlemede, gebelikte T. gondii enfeksiyonunun dünyada ve Türkiye’de seroprevalansı, fetüs üzerine etkileri, korunma yolları, tarama konusundaki görüş ve önerilerin literatür eşliğinde gözden geçirilmesi, birinci basamak hekimleri için klinik uygulamalarda yol gösterici olması amaçlanmıştır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Montoya JG. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J İnfect Dis. 2002;185(Supplement_1):P73-82. https://doi.org/10.1086/338827
  • 2. Hegab SM, Al-Mutawa SA. Immunopathogenesis of toxoplasmosis. Clin and Exp Med. 2003;3(2):84-105. https://doi.org/10.1007/s10238-003- 0011-2
  • 3. Saricaoglu EM, Memikoglu KO. [Pregnancy and Toxoplasmosis]. (in Turkish). Journal of Ankara University Faculty Medicine. 2018; 71:17-22. http://dergiler.ankara.edu.tr/dergiler/36/2263/23548.pdf
  • 4. Zeteroglu S. Toksoplazmosis. In: Intrauterine infections; Parasitic Infections, Cicek N, Akyurek C, Celik C, Haberal A (editors). Gynecology and Obstetrics Textbook, 2th ed, chp 64. Gunes Publishing, Istanbul, 2006;P720-72.
  • 5. Yazar S, Yaman O, Sahin I. [Evaluation of the Results of IgG Avidity Testing of Toxoplasma gondii in Pregnant Women] (in Turkish) Turkiye Parazitol Derg 2005; 29(4):221-3. http://parazitoloji.dergisi.org/pdf/pdf_TPD_1.pdf
  • 6. Tanriverdi EÇ, Kadioglu BG, Alay H, Ozkurt Z. Retrospective Evaluation of Anti-Toxoplasma gondii Antibody Among First Trimester Pregnant Women Admitted to Nenehatun Maternity Hospital between 2013-2017 in Erzurum. Turkiye Parazitol Derg, 2018; 42(2):101-5. http://cms.galenos.com.tr/Uploads/Article_21627/TPD-42-101-En.pdf
  • 7. Montaya JG, Remington JS. Toxoplasma gondii. Fifth edition. New York, Churchill Livingstone. 2001;p30. 8. Torgerson PR, Mastroiacovo P. The global burden of congenital toxoplasmosis: a systematic review. Bulletin of the World Health Organization. 2013; 91:501-8. https://www.who.int/bulletin/volumes/91/7/12-111732.pdf
  • 9. Hill D, Dubey JP. Toxoplasma gondii: transmission, diagnosis and prevention. Clin Microbiol İnfect, 2002. 8(10):634-40. https://doi.org/10.1046/j.1469-0691.2002.00485.x
  • 10. Liu Q, Wei F, Gao S, Jiang L, Lian H, Yuan B, et al. Toxoplasma gondii infection in pregnant women in China. Trans R Soc Trop Med Hyg. 2009; 103(2):162-6. https://doi.org/10.1016/j.trstmh.2008.07.008
  • 11. Sakikawa M, Noda S, Hanaoka M, Nakayama H, Hojo S, Kakinoki S, et al. Anti-Toxoplasma antibody prevalence, primary infection rate, and risk factors in a study of toxoplasmosis in 4,466 pregnant women in Japan. Clin. Vaccine Immunol. 2012. 19(3):365-7. https://www.ncbi.nlm.nih.gov/pubmed/22205659
  • 12. Khurana S, Bagga R, Aggarwal A, Lyngdoh V, Diddi K, Malla N. Serological screening for antenatal toxoplasma infection in India. J Med Microbiol. 2010. 28(2):143-6. https://doi.org/10.4103/0255-0857.62492
  • 13. Bakacak M, Bostanci MS, Kostu B, Ercan O, Serin S, Avci F. [Seroprevalance of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women] (in Turkish). Dicle Med J, 2014; 41(2):326-31. https://doi.org/10.5798/diclemedj.0921.2014.02.0425
  • 14. Tekay F, Ozbek E. [The Seroprevalence of Toxoplasma gondii in Women from Sanliurfa, a Province with a High Raw Meatball Consumption] (in Turkish). Turkiye Parazitol Derg. 2007;31(3):176-9. http://www.parazitoloji.dergisi.org/pdf/pdf_TPD_266.pdf
  • 15. Madazli R. Toxoplasma Infection. İstanbul; İstanbul Medical Publishing; 2017; p310. http://tmftp.org/webkontrol/uploads/files/GebelikteTaramaveOngoru.pdf
  • 16. Montoya JG, Toxoplasma gondii. Wilson WR, Sande MA ed. Dundar IH translation ed. [Infectious diseases, diagnosis, and treatment]. 1st ed. Istanbul: Nobel Medical Publishing, 2004; 807–16.
  • 17. Di Mario S, Basevi V, Gagliotti C, Spettoli D, Gori G, D'Amico R, et al. Prenatal education for congenital toxoplasmosis. Cochrane Database of Systematic Reviews. 2013;(2): CD006171. https://doi.org/10.1002/14651858.CD006171.pub3
  • 18. Remington JS, Klein JO, Alpert JJ. Current concepts of infections of the fetus and newborn infant. In Infectious diseases of the fetus and newborn
  • infant. WB Saunders ed. 2001. P9. 19. Bahar IH, Karaman M, Kirdar S, Yilmaz O, Celiloglu M, Mutlu D. [The Importance and Validity of anti-Toxoplasma gondii IgG, IgM, IgA Antibodies and IgG Avidity Tests in the Diagnosis of Toxoplasmosis Infection during Pregnancy] (in Turkish). Turkiye Parazitol Derg. 2005;29(2):76-9. http://parazitoloji.dergisi.org/pdf/pdf_TPD_103.pdf
  • 20. SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group. Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' data. Lancet. 2007; 369 : 115-22. https://doi.org/10.1016/S0140-6736(07)60072-5
  • 21. Paquet C, Yudin MH, Allen VM, Bouchard C, Boucher M, Caddy S. et al. Toxoplasmosis in pregnancy: prevention, screening, and treatment. J Obstet Gynaecol Can. 2013;35(1):78-9. https://doi.org/10.1016/S1701-2163(15)31053-7
  • 22. Liesenfeld O, Montoya JG, Kinney S, Press C, Remington JS. Effect of testing for IgG avidity in the diagnosis of Toxoplasma gondii infection in pregnant women: experience in a US reference laboratory. J Infect Dis. 2001;183(8):1248-53. https://doi.org/10.1086/319672
  • 23. Liesenfeld O, Press C, Montoya JG, Gill R, Isaac-Renton JL, Hedman K, et al. False-positive results in immunoglobulin M (IgM) toxoplasma antibody tests and importance of confirmatory testing: the Platelia Toxo IgM test. J Clin Microbiol. 1997;35(1):174-8. https://jcm.asm.org/content/jcm/35/1/174.full.pdf
  • 24. American College of Obstetricians and Gynecologists. Practice bulletin no. 151: Cytomegalovirus, parvovirus B19, varicella zoster, and toxoplasmosis in pregnancy. Obstet Gynecol. 2015;125(6):1510-25. https://doi.org/10.1097/01.AOG.0000466430.19823.53
  • 25. Goldstein EJC, Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Inf Dis. 2008;47(4):554-66. https://doi.org/10.1086/590149
  • 26. McLeod R, Kieffer F, Sautter M, Hosten T, Pelloux H. Why prevent, diagnose and treat congenital toxoplasmosis? Mem. Inst. Oswaldo Cruz. 2009;104(2):320-44. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735102/
  • 27. Bénard A, Salmi R. European Toxo Prevention Study Group (EUROTOXO).Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis. Euro Surveill. 2008;10;13(15). pii:18834. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740836/
  • 28. Society of Obstetricians and Gynaecologists of Canada (SOGC) (2013b) Clinical Practice Guideline. Toxoplasmosis in Pregnancy: Prevention, Screening, and Treatment. J Obstet Gynaecol Can 2013;35(1 eSuppl A):S1–S7. https://www.sogc.org/guidelines/toxoplasmosis-in-pregnancyprevention-screening-and-treatment/
  • 29. Mittendorf R, Pryde P, Herschel M, Williams MA. Is routine antenatal toxoplasmosis screening justified in the United States? Statistical considerations in the application of medical screening tests. Clin Obstet Gynecol. 1999;42(1):163-73. https://www.ncbi.nlm.nih.gov/pubmed/10073309
  • 30. Saadatnia G, Golkar M. A review on human toxoplasmosis. Scandinavian j İnfect Dis. 2012;44(11):805-14. https://doi.org/10.3109/00365548.2012.693197
  • 31. Hokelek M, Uyar Y, Gunaydin M, Cetin M. [Investigation of Toxoplasma Antibodies Seroprevalence in Samsun Region] (in Turkish). J Exp Clin Med. 2010;17(1):50-55. http://www.parazitoloji.dergisi.org/pdf/pdf_TPD_447.pdf
  • 32. Royal College of Obstetricians Gynecologists. http://www.rcog.org.uk/womens-health/clinical-guidance/infection-and-pregnancy-study-groupstatement
  • 33. Centers for Disease Control and Prevention. Preventing congenital toxoplasmosis. Recommendations and reports. MMVR. 2000;49. https://www.cdc.gov/mmwr/preview/mmwrhtml/rr4902a5.htm
  • 34. Turkish Ministry of Health, Institution of Public Health, Women and Reproductive Health Department. [Obstetric Care and Management Guideline].(in Turkish) 2018. Ankara. https://sbu.saglik.gov.tr/Ekutuphane/kitaplar/dogumonubakim.pdf
  • 35. Müngen E. Toxoplasmosis screening in pregnancy. Perinatal Journal. 2010;18(3):69-71. http://www.perinataldergi.com/Files/Archive/trTR/Articles/PD-1111.pdf
APA Çınar Tanrıverdi E, Ozkurt Z, Cayir Y, Uslu H (2019). Pregnancy and Toxoplasmosis: should screening be a routine practice?. , 74 - 78.
Chicago Çınar Tanrıverdi Esra,Ozkurt Zulal,Cayir Yasemin,Uslu Hakan Pregnancy and Toxoplasmosis: should screening be a routine practice?. (2019): 74 - 78.
MLA Çınar Tanrıverdi Esra,Ozkurt Zulal,Cayir Yasemin,Uslu Hakan Pregnancy and Toxoplasmosis: should screening be a routine practice?. , 2019, ss.74 - 78.
AMA Çınar Tanrıverdi E,Ozkurt Z,Cayir Y,Uslu H Pregnancy and Toxoplasmosis: should screening be a routine practice?. . 2019; 74 - 78.
Vancouver Çınar Tanrıverdi E,Ozkurt Z,Cayir Y,Uslu H Pregnancy and Toxoplasmosis: should screening be a routine practice?. . 2019; 74 - 78.
IEEE Çınar Tanrıverdi E,Ozkurt Z,Cayir Y,Uslu H "Pregnancy and Toxoplasmosis: should screening be a routine practice?." , ss.74 - 78, 2019.
ISNAD Çınar Tanrıverdi, Esra vd. "Pregnancy and Toxoplasmosis: should screening be a routine practice?". (2019), 74-78.
APA Çınar Tanrıverdi E, Ozkurt Z, Cayir Y, Uslu H (2019). Pregnancy and Toxoplasmosis: should screening be a routine practice?. Aile Hekimliği ve Palyatif Bakım, 4(2), 74 - 78.
Chicago Çınar Tanrıverdi Esra,Ozkurt Zulal,Cayir Yasemin,Uslu Hakan Pregnancy and Toxoplasmosis: should screening be a routine practice?. Aile Hekimliği ve Palyatif Bakım 4, no.2 (2019): 74 - 78.
MLA Çınar Tanrıverdi Esra,Ozkurt Zulal,Cayir Yasemin,Uslu Hakan Pregnancy and Toxoplasmosis: should screening be a routine practice?. Aile Hekimliği ve Palyatif Bakım, vol.4, no.2, 2019, ss.74 - 78.
AMA Çınar Tanrıverdi E,Ozkurt Z,Cayir Y,Uslu H Pregnancy and Toxoplasmosis: should screening be a routine practice?. Aile Hekimliği ve Palyatif Bakım. 2019; 4(2): 74 - 78.
Vancouver Çınar Tanrıverdi E,Ozkurt Z,Cayir Y,Uslu H Pregnancy and Toxoplasmosis: should screening be a routine practice?. Aile Hekimliği ve Palyatif Bakım. 2019; 4(2): 74 - 78.
IEEE Çınar Tanrıverdi E,Ozkurt Z,Cayir Y,Uslu H "Pregnancy and Toxoplasmosis: should screening be a routine practice?." Aile Hekimliği ve Palyatif Bakım, 4, ss.74 - 78, 2019.
ISNAD Çınar Tanrıverdi, Esra vd. "Pregnancy and Toxoplasmosis: should screening be a routine practice?". Aile Hekimliği ve Palyatif Bakım 4/2 (2019), 74-78.