Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination

Cabalar, Murat; BOSTAN, Habib; KANAT, Ayhan; SALİHOĞLU, Ziya; ALTINAY, Serdar; balık, mehmet sabri; TUMKAYA, Levent; KALKAN, Yıldıray; ADEM, Erkut Sabri; KOÇER, Abdulkadir; ALTUNER, Dudu

doi:10.14744/nci.2017.28190

Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination

Habib BOSTAN, (Adalet Bakanlığı, Adli Tıp Kurumu, İstanbul, Türkiye)

Murat ÇABALAR, (Adalet Bakanlığı, Adli Tıp Kurumu, İstanbul, Türkiye)

Serdar ALTINAY, (Selçuk Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Konya, Türkiye)

Yıldıray KALKAN, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Histoloji Anabilim Dalı, Rize, Türkiye)

Levent TÜMKAYA, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Histoloji Anabilim Dalı, Rize, Türkiye)

Ayhan KANAT, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Rize, Türkiye)

Mehmet Sabri BALIK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Ortopedik Cerrahi Anabilim Dalı, Rize, Türkiye)

Erkut Sabri ADEM, (Recep Tayyip Erdoğan Üniversitesi Tıp Fakültesi Ortopedik Cerrahi Anabilim Dalı, Rize, Türkiye)

Dudu ALTUNER, (Rize Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Rize, Türkiye)

Ziya SALİHOĞLU, (Adalet Bakanlığı, Adli Tıp Kurumu, İstanbul, Türkiye)

Abdulkadir KOÇER, (Medeniyet Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, İstanbul, Türkiye)

Diğer Yazarlar

İstanbul Kuzey Klinikleri

1 0

Yıl: 2018 Cilt: 5 Sayı: 3 Sayfa Aralığı: 176 - 185 Metin Dili: İngilizce DOI: 10.14744/nci.2017.28190 İndeks Tarihi: 02-11-2020

Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination

Öz:

OBJECTIVE: Sciatic nerve neuropathy can be observed following intramuscular gluteal injections. The histopathologicalexamination of sciatic nerve damage following intramuscular injection in the gluteal region for acute pain treatment is notfeasible in humans due to the inability to dissect and examine the nerve tissue. To overcome this issue, we used a rat modelfor demonstrating damage to the sciatic nerve tissue after the application of commonly used drug injections.METHODS: We investigated possible damage following the intramuscular injection of diclofenac, lornoxicam, morphine, andpethidine in a rat model based on histopathological characteristics such as myelin degeneration, axon degeneration, epineuriumdegeneration, fibrosis, epineurium thickening, perineurium thickening, lymphocyte infiltration, vacuolization, and edema.RESULTS: All the analgesic drugs used in our study induced histopathological changes in the sciatic nerve. Anti-S100positivity, showing nerve damage, was found to be the lowest in the group treated with diclofenac. Neurotoxic effects ofdiclofenac on the sciatic nerve were greater than those of the other drugs used in the study. Lornoxicam induced the leasthistopathological changes in the nerve.CONCLUSION: Diclofenac induced severe nerve damage not only after direct injection in the sciatic nerve but also after injection in the area around the nerve. Thus, we recommend restricting the use of intramuscular gluteal injections of diclofenac.Intramuscular use of morphine and pethidine should also be overviewed.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BOSTAN H, Cabalar M, ALTINAY S, KALKAN Y, TUMKAYA L, KANAT A, balık m, ADEM E, ALTUNER D, SALİHOĞLU Z, KOÇER A (2018). Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. , 176 - 185. 10.14744/nci.2017.28190
Chicago	BOSTAN Habib,Cabalar Murat,ALTINAY Serdar,KALKAN Yıldıray,TUMKAYA Levent,KANAT Ayhan,balık mehmet sabri,ADEM Erkut Sabri,ALTUNER Dudu,SALİHOĞLU Ziya,KOÇER Abdulkadir Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. (2018): 176 - 185. 10.14744/nci.2017.28190
MLA	BOSTAN Habib,Cabalar Murat,ALTINAY Serdar,KALKAN Yıldıray,TUMKAYA Levent,KANAT Ayhan,balık mehmet sabri,ADEM Erkut Sabri,ALTUNER Dudu,SALİHOĞLU Ziya,KOÇER Abdulkadir Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. , 2018, ss.176 - 185. 10.14744/nci.2017.28190
AMA	BOSTAN H,Cabalar M,ALTINAY S,KALKAN Y,TUMKAYA L,KANAT A,balık m,ADEM E,ALTUNER D,SALİHOĞLU Z,KOÇER A Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. . 2018; 176 - 185. 10.14744/nci.2017.28190
Vancouver	BOSTAN H,Cabalar M,ALTINAY S,KALKAN Y,TUMKAYA L,KANAT A,balık m,ADEM E,ALTUNER D,SALİHOĞLU Z,KOÇER A Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. . 2018; 176 - 185. 10.14744/nci.2017.28190
IEEE	BOSTAN H,Cabalar M,ALTINAY S,KALKAN Y,TUMKAYA L,KANAT A,balık m,ADEM E,ALTUNER D,SALİHOĞLU Z,KOÇER A "Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination." , ss.176 - 185, 2018. 10.14744/nci.2017.28190
ISNAD	BOSTAN, Habib vd. "Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination". (2018), 176-185. https://doi.org/10.14744/nci.2017.28190

APA	BOSTAN H, Cabalar M, ALTINAY S, KALKAN Y, TUMKAYA L, KANAT A, balık m, ADEM E, ALTUNER D, SALİHOĞLU Z, KOÇER A (2018). Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. İstanbul Kuzey Klinikleri, 5(3), 176 - 185. 10.14744/nci.2017.28190
Chicago	BOSTAN Habib,Cabalar Murat,ALTINAY Serdar,KALKAN Yıldıray,TUMKAYA Levent,KANAT Ayhan,balık mehmet sabri,ADEM Erkut Sabri,ALTUNER Dudu,SALİHOĞLU Ziya,KOÇER Abdulkadir Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. İstanbul Kuzey Klinikleri 5, no.3 (2018): 176 - 185. 10.14744/nci.2017.28190
MLA	BOSTAN Habib,Cabalar Murat,ALTINAY Serdar,KALKAN Yıldıray,TUMKAYA Levent,KANAT Ayhan,balık mehmet sabri,ADEM Erkut Sabri,ALTUNER Dudu,SALİHOĞLU Ziya,KOÇER Abdulkadir Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. İstanbul Kuzey Klinikleri, vol.5, no.3, 2018, ss.176 - 185. 10.14744/nci.2017.28190
AMA	BOSTAN H,Cabalar M,ALTINAY S,KALKAN Y,TUMKAYA L,KANAT A,balık m,ADEM E,ALTUNER D,SALİHOĞLU Z,KOÇER A Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. İstanbul Kuzey Klinikleri. 2018; 5(3): 176 - 185. 10.14744/nci.2017.28190
Vancouver	BOSTAN H,Cabalar M,ALTINAY S,KALKAN Y,TUMKAYA L,KANAT A,balık m,ADEM E,ALTUNER D,SALİHOĞLU Z,KOÇER A Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination. İstanbul Kuzey Klinikleri. 2018; 5(3): 176 - 185. 10.14744/nci.2017.28190
IEEE	BOSTAN H,Cabalar M,ALTINAY S,KALKAN Y,TUMKAYA L,KANAT A,balık m,ADEM E,ALTUNER D,SALİHOĞLU Z,KOÇER A "Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination." İstanbul Kuzey Klinikleri, 5, ss.176 - 185, 2018. 10.14744/nci.2017.28190
ISNAD	BOSTAN, Habib vd. "Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination". İstanbul Kuzey Klinikleri 5/3 (2018), 176-185. https://doi.org/10.14744/nci.2017.28190