İkinci Beyin: Bağırsak

Koca, Oğuzcan; Dönmez, Nurcan

doi:10.17094/ataunivbd.701620

İkinci Beyin: Bağırsak

Oğuzcan KOCA, (Selçuk Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)

Nurcan DONMEZ (Selçuk Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

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Yıl: 2020 Cilt: 15 Sayı: 2 Sayfa Aralığı: 187 - 195 Metin Dili: Türkçe DOI: 10.17094/ataunivbd.701620 İndeks Tarihi: 04-11-2020

İkinci Beyin: Bağırsak

Öz:

Bağırsak mikrobiyotası konakçılara paralel olarak gelişen ve konakçının fizyolojik ortamına bağlı karmaşık bir ekosistemitemsil etmektedir. Enterik sinir sisteminin 100 milyondan fazla nöron içermesi ve merkezi sinir sisteminden bağımsız işlevgörebilmesi onun ikinci beyin olarak adlandırılmasına da neden olmuştur. Bağırsak mikrobiyotası beyin ve bağırsak arasındabir ilişki oluşturarak insan sağlığı üzerinde önemli bir rol oynar. Hastalıklarla bağırsak mikrobiyotası arasındaki ilişkiincelendiğinde bazı hastalıklarda özel bir mikrobiyota olduğu ortaya konmuştur. Bu mikrobiyota sağlıklı bir insanınmikrobiyotasından farklıdır. Obezite, diyabet gibi metabolik hastalıklar ve Parkinson, Alzheimer gibi nörodejeneratifbozukluklarla bağırsak mikrobiyotası arasında bağlantı olduğuna ilişkin güçlü kanıtlar sunulmuştur. Yapılan araştırmalargastrointestinal sistemde yaşayan faydalı ve zararlı mikroorganizmaların immün sistemi, nöral yolakları ve merkezi sinirsistemini uyardığını ortaya koymaktadır. Bu mikroorganizmalar beyin ve bağırsak için önemli olan gama amino bütirik asit,dopamin ve serotonin gibi nörotransmitter maddeleri üretmektedir. Son yıllarda bağırsak mikrobiyotasına olan ilgi ve budoğrultuda yapılan çalışmalar bu bakterilerin çevresel faktörlerden nasıl etkilendiğini ve sinir sistemi üzerinde nasıl etkileroluşturabildiğini göstermiştir. Çevresel etkenler ve beslenmenin bağırsak mikrobiyotası üzerindeki etkileri de son yıllardaaçığa çıkmaya başlamıştır. Bu makalede bağırsak mikrobiyotasının beyin, davranış ve nöropsikiyatrik bozukluklar üzerine etkisiincelenmiştir.

Anahtar Kelime:

Second Brain: Gut

Öz:

Intestinal microbiota represents a complex ecosystem that develops in parallel with the hosts and depends on the physiological environment of the host. The enteric nervous system containing more than 100 million neurons and its ability to function independently from the central nervous system also caused it to be called the second brain. The gut microbiota plays an important role in human health by creating a relationship between the brain and the gut. When the relationship between diseases and intestinal microbiota is examined, it is revealed that there is a special microbiota in some diseases. This microbiota is different from the microbiota of a healthy person. Strong evidence is provided that there is a link between metabolic diseases such as obesity, diabetes, and neurodegenerative disorders such as Parkinson and Alzheimer's, and intestinal microbiota. Research shows that beneficial and harmful microorganisms living in the gastrointestinal tract stimulate the immune system, neural pathways and central nervous system. These microorganisms produce neurotransmitter substances such as gamma amino butyric acid, dopamine and serotonin, which are important for the brain and intestine. In this article, the effects of intestinal microbiota on brain, behavior and neuropsychiatric disorders were investigated.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Koca O, Dönmez N (2020). İkinci Beyin: Bağırsak. , 187 - 195. 10.17094/ataunivbd.701620
Chicago	Koca Oğuzcan,Dönmez Nurcan İkinci Beyin: Bağırsak. (2020): 187 - 195. 10.17094/ataunivbd.701620
MLA	Koca Oğuzcan,Dönmez Nurcan İkinci Beyin: Bağırsak. , 2020, ss.187 - 195. 10.17094/ataunivbd.701620
AMA	Koca O,Dönmez N İkinci Beyin: Bağırsak. . 2020; 187 - 195. 10.17094/ataunivbd.701620
Vancouver	Koca O,Dönmez N İkinci Beyin: Bağırsak. . 2020; 187 - 195. 10.17094/ataunivbd.701620
IEEE	Koca O,Dönmez N "İkinci Beyin: Bağırsak." , ss.187 - 195, 2020. 10.17094/ataunivbd.701620
ISNAD	Koca, Oğuzcan - Dönmez, Nurcan. "İkinci Beyin: Bağırsak". (2020), 187-195. https://doi.org/10.17094/ataunivbd.701620

APA	Koca O, Dönmez N (2020). İkinci Beyin: Bağırsak. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 15(2), 187 - 195. 10.17094/ataunivbd.701620
Chicago	Koca Oğuzcan,Dönmez Nurcan İkinci Beyin: Bağırsak. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 15, no.2 (2020): 187 - 195. 10.17094/ataunivbd.701620
MLA	Koca Oğuzcan,Dönmez Nurcan İkinci Beyin: Bağırsak. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol.15, no.2, 2020, ss.187 - 195. 10.17094/ataunivbd.701620
AMA	Koca O,Dönmez N İkinci Beyin: Bağırsak. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2020; 15(2): 187 - 195. 10.17094/ataunivbd.701620
Vancouver	Koca O,Dönmez N İkinci Beyin: Bağırsak. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2020; 15(2): 187 - 195. 10.17094/ataunivbd.701620
IEEE	Koca O,Dönmez N "İkinci Beyin: Bağırsak." Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 15, ss.187 - 195, 2020. 10.17094/ataunivbd.701620
ISNAD	Koca, Oğuzcan - Dönmez, Nurcan. "İkinci Beyin: Bağırsak". Atatürk Üniversitesi Veteriner Bilimleri Dergisi 15/2 (2020), 187-195. https://doi.org/10.17094/ataunivbd.701620