BACKGROUND: This study aims to compare liver transplant and non-liver transplant patients who underwent appendectomy witha presumed diagnosis of acute appendicitis.METHODS: Demographic and clinicopathological features of 13 liver transplant recipients (transplant group) who underwent posttransplantappendectomy with a presumed diagnosis of acute appendicitis were compared with the features of 52 non-liver transplantpatients (non-transplant group). They underwent appendectomy with a presumed diagnosis of acute appendicitis during the same timeperiod. The transplant group was matched at random in a 1: 4 ratio with the non- transplant group. While the continuous variableswere compared using the Mann Whitney-U test, categorical variables were compared with Fisher’s exact test. A p-value of less than0.05 was considered statistically significant.RESULTS: A total of 65 patients aged between one year and 84 years were included in this study. While the age of the 52 patients(32 male and 20 female) in the non- transplant group ranged from 17 years to 84 years, the age of the 13 patients (nine male and fourfemale) in the transplant group ranged from one year to 64 years. Statistically significant differences were noted between both groupsconcerning WBC (p=0.002), neutrophil (p=0.002), lymphocyte (p=0.032), platelets (p=0.032), RDW (p=0.001), CRP (p=0.009), PNR(p=0.042), WNR (p=0.03), and appendiceal length (p<0.001). The negative appendectomy rate was relatively higher in transplant thanthe non-transplant group but this difference was not statistically significant (30.8% vs. 21.2%; p=0.477). Perforated acute appendicitisoccurred more frequently in the transplant group; however, this difference was not statistically significant (30.8% vs. 9.6%; p=0.070).CONCLUSION: WBC and neutrophil were lower in the LT group; however, the CRP and RDW were higher in the LT group. Further,perforation and negative appendectomy rates were higher in the LT group, although this difference was not statistically significant.