Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery
Yıl: 2020 Cilt: 26 Sayı: 5 Sayfa Aralığı: 735 - 741 Metin Dili: İngilizce DOI: 10.14744/tjtes.2020.81783 İndeks Tarihi: 03-11-2020
Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery
Öz: BACKGROUND: Acute abdominal surgery has a high rate of mortality and morbidity, and intensive care is often needed in the postoperativeperiod. In intensive care units, various scoring systems are used to determine prognosis and mortality but are not sufficientto predict mortality and prognosis. For this purpose, easily applicable, effective methods are being investigated. In this study, we aimedto investigate the relationship between mortality and blood parameters, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyteratio (PLR), and mean platelet volume (MPV), in patients undergoing acute abdominal surgery.METHODS: This study included a total of 249 patients who underwent acute abdominal surgery. The patients were divided intotwo groups as survivors (n=126) and non-survivors (n=123). The patient data were retrospectively analysed. The NLR, PLR, and MPVvalues were compared between the groups. Data including age, sex, Acute Physiology and Chronic Health Evaluation II-IV scores(APACHEII-IV), Sequential Organ Failure Assessment scores (SOFA), Glasgow Coma Scale were assessed.RESULTS: The mortality rate was 49.4% in our study. There was no statistically significant difference in the NLR and PLR valuesbetween the groups. However, MPV was significantly higher in the non-survivors group (p<0.004).CONCLUSION: Our study results showed that MPV values were significantly higher in the non-survivors following acute abdominalsurgery, and NLR and PLR were not associated with mortality.
Anahtar Kelime: Akut karın cerrahisi geçiren hastalarda, nötrofil-lenfosit oranı, trombosit-lenfosit oranı ve ortalama trombosit hacminin mortalite ile ilişkisi
Öz: AMAÇ: Akut karın cerrahisi sonrası yüksek oranda mortalite ve morbidite görülmekte, postoperatif dönemde sıklıkla yoğun bakım ihtiyacı olmaktadır. Yoğun bakım ünitelerinde, prognoz ve mortaliteyi belirlemek amacıyla çeşitli skorlama sistemleri kullanılmakta ancak mortalite ve prognozu öngörmede yeterli olmamaktadır. Bu amaçla kolay uygulanabilir, etkin yöntemler araştırılmaktadır. Biz bu çalışmada, akut karın cerrahisi geçiren hastalarda nötrofil-lenfosit oranı (NLO), trombosit-lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH) gibi kan parametrelerinin mortalite ile ilişkisini araştırmayı amaçladık. GEREÇ VE YÖNTEM: Bu çalışmaya, akut karın ameliyatı geçiren 249 hasta alındı. Hastalar sağ kalan (n=126) ve ölenler (n=123) olarak iki gruba ayrıldı. Hasta verileri retrospektif olarak incelendi. NLO, TLO ve OTH değerleri gruplar arasında karşılaştırıldı. Yaş, cinsiyet, Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi II-IV skorları (APACHEII-IV), Sıralı Organ Yetmezliği Değerlendirme skorları (SOFA), Glasgow Koma Skalası gibi veriler değerlendirildi. BULGULAR: Çalışmamızda mortalite oranı %49.4 idi. NLO ve TLO değerlerinde gruplar arasında istatistiksel olarak anlamlı fark yoktu. Ancak, OTH ölenler grubunda anlamlı olarak yüksek bulundu (p<0.004). TARTIŞMA: Çalışma sonuçlarımız akut karın cerrahisi sonrası hayatını kaybedenlerde OTH değerlerinin anlamlı derecede yüksek olduğunu ve NLO ve TLO’nın mortalite ile ilişkili olmadığını göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Turan M, Şen M, Koyuncu A, Aydın C, Karadayı K, Canbay E. The Acute Abdomen with Recent Advances. Cumhurıyet University J Med School 2002;24:45−52.
- 2. Quach S, Hennessy DA, Faris P, Fong A, Quan H, Doig C. A comparison between the APACHE II and Charlson Index Score for predicting hospital mortality in critically ill patients. BMC Health Serv Res 2009;30:9:129.
- 3. Güç D. Inflammation. J Curr Med 1998;3:126−4.
- 4. Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5−14.
- 5. Aktimur R, Cetinkunar S, Yildirim K, Aktimur SH, Ugurlucan M, Ozlem N. Neutrophil-to-lymphocyte ratio as a diagnostic biomarker for the diagnosis of acute mesenteric ischemia. Eur J Trauma Emerg Surg 2016;42:363−8
- 6. Jung J, Park SY, Park SJ, Park J. Prognostic value of the neutrophil- to-lymphocyte ratio for overall and disease-free survival in patients with surgically treated esophageal squamous cell carcinoma. TumourBiol 2016;37:7149−54.
- 7. Dirican N, Karakaya YA, Gunes S, Daloglu FT, Dirican A. Association of intra-tumoral tumour-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio is an independent prognostic factor in non-small cell lung cancer. Clin Respir J 2017;11:789−96.
- 8. Zhou D, Wan Z, Fan Y, Zhou J, Yuan Z. A combination of the neutrophil- to-lymphocyte ratio and the GRACE risk score better predicts PCI outcomes in Chinese Han patients with acute coronary syndrome. Anatol J Cardiol 2015;15:995−1001.
- 9. Tekeoğlu İ, Gürol G, Harman H, Karakeçe E, Çiftçi İH. Overlooked hematological markers of disease activity in rheumatoid arthritis. Int J Rheum Dis 2016;19:1078−82.
- 10. Sevim Y, Namdaroglu OB, Akpınar MY, Ertem AG. The diagnostic value of neutrophil lymphocyte ratio in acute appendicitis. Sakaryamj 2014;4:78−81.
- 11. Forget P, Khalifa C, Defour JP, Latinne D, Van Pel MC, De Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio?. BMC Res Notes 2017;10:12.
- 12. Augène E, Lareyre F, Chikande J, Guidi L, Ballaith A, Bossert JN, Pelletier Y, Caradu C, Hassen-Khodja R, Raffort J. Platelet to lymphocyte ratio as a predictive factor of 30-day mortality in patients with acute mesenteric ischemia. PLoS One 2019;14:e0219763.
- 13. Paraskevas F, Greer JP, Rodgers GM. Variations of leucocytes in disease. In: Wintrobe’s Clinical Hematology. Lee GR, Foerster J, Lukens J, editors. 10th edition. Baltimore: Lippincott Williams and Wilkins;1999.p.1836−61.
- 14. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148−56.
- 15. Azab B, Torbey E, Singh J, Akerman M, Khoueiry G, McGinn JT, et al. Mean platelet volume/platelet count ratio as a predictor of longterm mortality after non-ST-elevation myocardial infarction. Platelets 2011;22:557−66.
- 16. Beyazit Y, Sayilir A, Torun S, Suvak B, Yesil Y, Purnak T, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol 2012;36:162−8.
- 17. Akbal E, Demirci S, Koçak E, Köklü S, Başar O, Tuna Y. Alterations of platelet function and coagulation parameters during acute pancreatitis. Blood Coagul Fibrinolysis 2013;24:243−6.
- 18. Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, Park KS, et al. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock. PLoS One 2015;10:e0119437.
- 19. Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F, et al. Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. Am J Surg 2009;197:466−72.
- 20. Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Choi HJ, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012;17:216−22.
- 21. Yılmaz EM, Cartı EB. Prognostic factors in acute mesenteric ischemia and evaluation with Mannheim Peritonitis Index and platelet-to-lymphocyte ratio. Ulus Travma Acil Cerrahi Derg 2017;23:301−5.
- 22. Duman A, Akoz A, Kapci M, Ture M, Orun S, Karaman K, Turkdogan KA. Prognostic value of neglected biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase. Am J Emerg Med 2016;34:2167−71.
- 23. Lin BD, Hottenga JJ, Abdellaoui A, Dolan CV, de Geus EJC, Kluft C, et al. Causes of variation in the neutrophil-lymphocyte and platelet-lymphocyte ratios: a twin-family study. Biomark Med 2016;10:1061−72.
- 24. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol 2016;26:372−6.
- 25. Jansen TC, van Bommel J, Mulder PG, Lima AP, van der Hoven B, et al. Prognostic value of blood lactate levels: does the clinical diagnosis at admission matter? J Trauma 2009;66:377−85.
- 26. Brinkman S, Bakhshi-Raiez F, Abu-Hanna A, de Jonge E, Bosman RJ, Peelen L, et al. External validation of Acute Physiology and Chronic Health Evaluation IV in Dutch intensive care units and comparison with Acute Physiology and Chronic Health Evaluation II and Simplified Acute Physiology Score II. J Crit Care 2011;26:105.e11-105. e1.05E18.
- 27. Hwang SY, Lee JH, Lee YH, Hong CK, Sung AJ, Choi YC. Comparison of the Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II scoring system, and Trauma and Injury Severity Score method for predicting the outcomes of intensive care unit trauma patients. Am J Emerg Med 2012;30:749−53.
| APA | Çolakoğlu Ş, Genç Moralar D, Tok Cekmecelioglu B, Hergunsel G (2020). Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. , 735 - 741. 10.14744/tjtes.2020.81783 |
| Chicago | Çolakoğlu Şükran merve,Genç Moralar Döndü,Tok Cekmecelioglu Busra,Hergunsel Gulsum Oya Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. (2020): 735 - 741. 10.14744/tjtes.2020.81783 |
| MLA | Çolakoğlu Şükran merve,Genç Moralar Döndü,Tok Cekmecelioglu Busra,Hergunsel Gulsum Oya Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. , 2020, ss.735 - 741. 10.14744/tjtes.2020.81783 |
| AMA | Çolakoğlu Ş,Genç Moralar D,Tok Cekmecelioglu B,Hergunsel G Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. . 2020; 735 - 741. 10.14744/tjtes.2020.81783 |
| Vancouver | Çolakoğlu Ş,Genç Moralar D,Tok Cekmecelioglu B,Hergunsel G Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. . 2020; 735 - 741. 10.14744/tjtes.2020.81783 |
| IEEE | Çolakoğlu Ş,Genç Moralar D,Tok Cekmecelioglu B,Hergunsel G "Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery." , ss.735 - 741, 2020. 10.14744/tjtes.2020.81783 |
| ISNAD | Çolakoğlu, Şükran merve vd. "Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery". (2020), 735-741. https://doi.org/10.14744/tjtes.2020.81783 |
| APA | Çolakoğlu Ş, Genç Moralar D, Tok Cekmecelioglu B, Hergunsel G (2020). Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. Ulusal Travma ve Acil Cerrahi Dergisi, 26(5), 735 - 741. 10.14744/tjtes.2020.81783 |
| Chicago | Çolakoğlu Şükran merve,Genç Moralar Döndü,Tok Cekmecelioglu Busra,Hergunsel Gulsum Oya Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. Ulusal Travma ve Acil Cerrahi Dergisi 26, no.5 (2020): 735 - 741. 10.14744/tjtes.2020.81783 |
| MLA | Çolakoğlu Şükran merve,Genç Moralar Döndü,Tok Cekmecelioglu Busra,Hergunsel Gulsum Oya Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. Ulusal Travma ve Acil Cerrahi Dergisi, vol.26, no.5, 2020, ss.735 - 741. 10.14744/tjtes.2020.81783 |
| AMA | Çolakoğlu Ş,Genç Moralar D,Tok Cekmecelioglu B,Hergunsel G Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(5): 735 - 741. 10.14744/tjtes.2020.81783 |
| Vancouver | Çolakoğlu Ş,Genç Moralar D,Tok Cekmecelioglu B,Hergunsel G Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery. Ulusal Travma ve Acil Cerrahi Dergisi. 2020; 26(5): 735 - 741. 10.14744/tjtes.2020.81783 |
| IEEE | Çolakoğlu Ş,Genç Moralar D,Tok Cekmecelioglu B,Hergunsel G "Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery." Ulusal Travma ve Acil Cerrahi Dergisi, 26, ss.735 - 741, 2020. 10.14744/tjtes.2020.81783 |
| ISNAD | Çolakoğlu, Şükran merve vd. "Relationship of mortality with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume in patients undergoing acute abdominal surgery". Ulusal Travma ve Acil Cerrahi Dergisi 26/5 (2020), 735-741. https://doi.org/10.14744/tjtes.2020.81783 |
