Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation

Nesrin KHAYYO, (Gaziantep Üniversitesi ,Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Gaziantep, Türkiye)
Hasan ULUSAL, (Gaziantep Üniversitesi ,Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Gaziantep, Türkiye)
Mehmet TARAKÇIOĞLU, (Gaziantep Üniversitesi ,Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Gaziantep, Türkiye)
Seyithan TAYSI, (Gaziantep Üniversitesi ,Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Gaziantep, Türkiye)
Muhammed Enes TAYSI, (Gaziantep Üniversitesi,Tıp Fakültesi, Gaziantep, Türkiye)
Elif DEMİR, (Harran Üniversitesi ,Sağlık Fakültesi ,Biyokimya Anabilim Dalı, Şanlıurfa, Türkiye)
Kadir ÇINAR (Sanko Üniversitesi ,Tıp Fakültesi ,Nöroşirürji Anabilim Dalı, Gaziantep, Türkiye)
European Journal of Therapeutics
6 1
Yıl: 2019 Cilt: 25 Sayı: 4 Sayfa Aralığı: 265 - 272 Metin Dili: İngilizce DOI: 10.5152/EurJTher.2019.18052 İndeks Tarihi: 05-11-2020

Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation

Öz:
Objective: In this study, we evaluated whether caffeic acid phenethyl ester (CAPE) has a radioprotective effect on the damage in the rat brain tissue induced by gamma radiation, considering that it may inhibit the ionizing radiation damage.Methods: A total of 36 Sprague–Dawley rats were divided into four groups to test the radioprotective effect of CAPE administered by intraperitoneal injection. An appropriate control group was also studied. On day 11, the brain tissue of all rats was removed and homogenized in phosphate buffer, and the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON), arylesterase (ARE), ceruloplasmin (CER), lipid hydroperoxide (LOOH), and total-SH parameters were measured to determine if CAPE had a protective effect.Results: The ARE and PON activity and the total-SH level were statistically increased compared to the IR group, whereas the LOOH, TOS, and OSI levels were significantly decreased.Conclusion: The data obtained in the study suggest that the CAPE administration prior to irradiation may prevent the irradiation brain damage.
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APA KHAYYO N, ULUSAL H, tarakcioglu m, Taysı S, Taysı M, Demir E, çınar k (2019). Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. , 265 - 272. 10.5152/EurJTher.2019.18052
Chicago KHAYYO NESRIN,ULUSAL HASAN,tarakcioglu mehmet,Taysı Seyithan,Taysı Muhammed Enes,Demir Elif,çınar kadir Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. (2019): 265 - 272. 10.5152/EurJTher.2019.18052
MLA KHAYYO NESRIN,ULUSAL HASAN,tarakcioglu mehmet,Taysı Seyithan,Taysı Muhammed Enes,Demir Elif,çınar kadir Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. , 2019, ss.265 - 272. 10.5152/EurJTher.2019.18052
AMA KHAYYO N,ULUSAL H,tarakcioglu m,Taysı S,Taysı M,Demir E,çınar k Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. . 2019; 265 - 272. 10.5152/EurJTher.2019.18052
Vancouver KHAYYO N,ULUSAL H,tarakcioglu m,Taysı S,Taysı M,Demir E,çınar k Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. . 2019; 265 - 272. 10.5152/EurJTher.2019.18052
IEEE KHAYYO N,ULUSAL H,tarakcioglu m,Taysı S,Taysı M,Demir E,çınar k "Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation." , ss.265 - 272, 2019. 10.5152/EurJTher.2019.18052
ISNAD KHAYYO, NESRIN vd. "Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation". (2019), 265-272. https://doi.org/10.5152/EurJTher.2019.18052
APA KHAYYO N, ULUSAL H, tarakcioglu m, Taysı S, Taysı M, Demir E, çınar k (2019). Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. European Journal of Therapeutics, 25(4), 265 - 272. 10.5152/EurJTher.2019.18052
Chicago KHAYYO NESRIN,ULUSAL HASAN,tarakcioglu mehmet,Taysı Seyithan,Taysı Muhammed Enes,Demir Elif,çınar kadir Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. European Journal of Therapeutics 25, no.4 (2019): 265 - 272. 10.5152/EurJTher.2019.18052
MLA KHAYYO NESRIN,ULUSAL HASAN,tarakcioglu mehmet,Taysı Seyithan,Taysı Muhammed Enes,Demir Elif,çınar kadir Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. European Journal of Therapeutics, vol.25, no.4, 2019, ss.265 - 272. 10.5152/EurJTher.2019.18052
AMA KHAYYO N,ULUSAL H,tarakcioglu m,Taysı S,Taysı M,Demir E,çınar k Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. European Journal of Therapeutics. 2019; 25(4): 265 - 272. 10.5152/EurJTher.2019.18052
Vancouver KHAYYO N,ULUSAL H,tarakcioglu m,Taysı S,Taysı M,Demir E,çınar k Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation. European Journal of Therapeutics. 2019; 25(4): 265 - 272. 10.5152/EurJTher.2019.18052
IEEE KHAYYO N,ULUSAL H,tarakcioglu m,Taysı S,Taysı M,Demir E,çınar k "Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation." European Journal of Therapeutics, 25, ss.265 - 272, 2019. 10.5152/EurJTher.2019.18052
ISNAD KHAYYO, NESRIN vd. "Radioprotective Effect of Caffeic Acid Phenethyl Ester on the Brain Tissue in Rats Who Underwent Total-Head Irradiation". European Journal of Therapeutics 25/4 (2019), 265-272. https://doi.org/10.5152/EurJTher.2019.18052
Sayfa Oluşturulma Tarihi
23-04-2024 14:46

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