Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency

CALISKANER, Ahmet Zafer; Arslan, Sevket; YILDIZ, ERAY; Aytekin, Gökhan; ÇÖLKESEN, FATİH

doi:10.21911/aai.504

Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency

Gökhan AYTEKİN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya,Türkiye)

Eray YILDIZ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya,Türkiye)

Fatih ÇÖLKESEN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya,Türkiye)

Şevket ARSLAN, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya,Türkiye)

Ahmet Zafer ÇALIŞKANER (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve Klinik İmmünoloji Anabilim Dalı, Konya,Türkiye)

Astım Allerji İmmünoloji

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Yıl: 2020 Cilt: 18 Sayı: 1 Sayfa Aralığı: 30 - 37 Metin Dili: İngilizce DOI: 10.21911/aai.504 İndeks Tarihi: 06-11-2020

Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency

Öz:

Objective: Common Variable Immune Deficiency (CVID) is a heterogeneous immune disorder characterized by impaired and/or inadequate B cell differentiation with hypogammaglobulinemia. It is characterized by frequent and recurrent respiratory infections, autoimmune disorders, chronic lung diseases, granulomatous diseases, and increased risk for lymphoid malignancies.Materials and Methods: The medical records of 47 patients (22 females, 25 males) who had been followed up at our clinic and had sufficient data in their files were retrospectively reviewed. Patients were diagnosed with CVID according to the ESID (European Society for Immunodeficiency) criteria.Results: The median age of the patients was 32 (19-65) years. The most frequent clinical presentation of the patients was with recurrent upper respiratory infections (46%), pneumonia (29.8%), otitis media (23.4%) and chronic sinusitis (17%). During the follow-up period, 17 patients (36.8%) developed autoimmune complications, 14 (29.8%) of whom had autoimmune cytopenia. A total of 26 patients (55.3%) had bronchiectasis confirmed with computed tomography of the thorax. Lymphopenia was detected in 13 patients (27.7%). The median immunoglobulin level at the time of diagnosis was IgG 2.77 (0.33-6.90) g/L, IgM 0.31 (0.06-5.99) g/L, and IgA 0.25 (0.01-5.02) g/L.Conclusion: CVID is very heterogeneous in terms of both clinical and laboratory features. Moreover, it is more common than expected, particularly in adulthood. The centers dealing with CVID should share their experiences in order to increase awareness among physicians.

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APA	Aytekin G, YILDIZ E, ÇÖLKESEN F, Arslan S, CALISKANER A (2020). Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. , 30 - 37. 10.21911/aai.504
Chicago	Aytekin Gökhan,YILDIZ ERAY,ÇÖLKESEN FATİH,Arslan Sevket,CALISKANER Ahmet Zafer Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. (2020): 30 - 37. 10.21911/aai.504
MLA	Aytekin Gökhan,YILDIZ ERAY,ÇÖLKESEN FATİH,Arslan Sevket,CALISKANER Ahmet Zafer Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. , 2020, ss.30 - 37. 10.21911/aai.504
AMA	Aytekin G,YILDIZ E,ÇÖLKESEN F,Arslan S,CALISKANER A Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. . 2020; 30 - 37. 10.21911/aai.504
Vancouver	Aytekin G,YILDIZ E,ÇÖLKESEN F,Arslan S,CALISKANER A Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. . 2020; 30 - 37. 10.21911/aai.504
IEEE	Aytekin G,YILDIZ E,ÇÖLKESEN F,Arslan S,CALISKANER A "Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency." , ss.30 - 37, 2020. 10.21911/aai.504
ISNAD	Aytekin, Gökhan vd. "Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency". (2020), 30-37. https://doi.org/10.21911/aai.504

APA	Aytekin G, YILDIZ E, ÇÖLKESEN F, Arslan S, CALISKANER A (2020). Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji, 18(1), 30 - 37. 10.21911/aai.504
Chicago	Aytekin Gökhan,YILDIZ ERAY,ÇÖLKESEN FATİH,Arslan Sevket,CALISKANER Ahmet Zafer Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji 18, no.1 (2020): 30 - 37. 10.21911/aai.504
MLA	Aytekin Gökhan,YILDIZ ERAY,ÇÖLKESEN FATİH,Arslan Sevket,CALISKANER Ahmet Zafer Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji, vol.18, no.1, 2020, ss.30 - 37. 10.21911/aai.504
AMA	Aytekin G,YILDIZ E,ÇÖLKESEN F,Arslan S,CALISKANER A Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji. 2020; 18(1): 30 - 37. 10.21911/aai.504
Vancouver	Aytekin G,YILDIZ E,ÇÖLKESEN F,Arslan S,CALISKANER A Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency. Astım Allerji İmmünoloji. 2020; 18(1): 30 - 37. 10.21911/aai.504
IEEE	Aytekin G,YILDIZ E,ÇÖLKESEN F,Arslan S,CALISKANER A "Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency." Astım Allerji İmmünoloji, 18, ss.30 - 37, 2020. 10.21911/aai.504
ISNAD	Aytekin, Gökhan vd. "Five Years of Experience in a Single Center: Retrospective Analysis of Adult Patients with Common Variable Immunodeficiency". Astım Allerji İmmünoloji 18/1 (2020), 30-37. https://doi.org/10.21911/aai.504