INTRODUCTION: Symptoms and interventional treatment modalities in chronic renal failure influence the wellbeing, daily performance and independence of daily living activities and often makes the individual dependent on someone else. The aim of the study was to determine the level of dependence of chronic renal failure patients and to evaluate the factors that cause dependence. METHODS: The cross-sectional study was carried out with 195 individuals who had been diagnosed with disease for at least one year, underwent hemodialysis treatment, aged 18 years or older, had no cognitive impairment and agreed to participate in the nephrology clinic of an university hospital between February and May 2019. Demographic information form, Care Dependency Scale, Fatigue Severity Scale and Visual Analog Pain Scale were used to collect study data. In the statistical analysis of the data; number, percentage, mean, Independent Samples T-Test, One Way Anova Test and Pearson’s correlation analysis were used. RESULTS: In the study, it was determined that patients with chronic renal failure had a moderate level of care dependence, level of care dependence was higher in mobility, dressing/removing clothes, avoidance of dangers, daily activities, recreational activities, and the level of age, educational status, presence of an additional chronic disease, duration of disease and some of the symptoms significantly affected the level of care dependence. However, age, education, presence of an additional chronic disease, duration of illness and symptoms of fatigue, pain, muscle weakness, loss of appetite and itching were found to affect the level of care dependence significantly. DISCUSSION AND CONCLUSION: Care dependence is an important issue to be evaluated in chronic renal failure patients and appropriate care, training, counseling and advocacy services should be used to support the independence of patients.